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SERUM SICKNESS FROM PENICILLIN: A Report of Twenty-Two Cases

SERUM SICKNESS FROM PENICILLIN: A Report of Twenty-Two Cases Abstract Since the first report on penicillin-sensitivity reactions by Keefer1 in 1943, there have been many subsequent reports. Brown,2 in 1948, reviewed the literature of 308 reports from 1943 to 1948. Beerman,3 in 1949, summarized the status of penicillin-sensitivity reactions and stated that one of the most frequently reported clinical pictures is that of a serum-sickness-like reaction. The first systematic study of the clinical and immunological phenomenon of serum sickness was done by von Pirquet and Schick4 and was reported in 1905. Cecil5 defines serum sickness as "allergic reaction resulting from the parenteral administration of a foreign serum and characterized by an incubation period, skin eruption, enlargement of lymph nodes, fever, edema and polyarthritis.'' A similar syndrome has been reported as a result of the sulfonamides.6 With the use of antibiotics, syndromes resembling serum sickness have been seen frequently resulting from penicillin. This syndrome has References 1. Keefer, C. S.; Blake, F. G.; Marshall, E. K., Jr.; Lockwood, S., Jr., and Wood, W. B., Jr.: Penicillin in the Treatment of Infections (500 Cases) , J. A. M. A. 122:1217-1224 ( (Aug. 18) ) 1943.Crossref 2. Brown, E. A.: Reactions to Penicillin , Ann. Allergy 6:723-746, 1948. 3. Beerman, H.: Drug Eruptions: A Survey of Recent Literature , Am. J. M. Sc. 218:446, 1949.Crossref 4. von Pirquet, C. F., and Schick, B.: Die Serum Krankheit , Leipzig, F. Deuticke, 1905. 5. Cecil, R. L.: Textbook of Medicine , Philadelphia, W. B. Saunders Company, 1951. 6. Longscope, W. T.: Serum Sickness and Analogous Reactions from Certain Drugs, Particularly the Sulfonamides , Medicine 22:251, 1943. 7. Zussman, B. M.: Severe Serum Sickness Type of Penicillin Reaction: Failure of Antihistamine Therapy , Ann. Allergy 8:751-753, 1950. 8. Hansel, F. K.: Penicillin Sensitivity , Ann. Allergy 7:619 and 624, 1949. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology & Syphilology American Medical Association

SERUM SICKNESS FROM PENICILLIN: A Report of Twenty-Two Cases

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Publisher
American Medical Association
Copyright
Copyright © 1952 American Medical Association. All Rights Reserved.
ISSN
0096-5979
DOI
10.1001/archderm.1952.01530250091011
Publisher site
See Article on Publisher Site

Abstract

Abstract Since the first report on penicillin-sensitivity reactions by Keefer1 in 1943, there have been many subsequent reports. Brown,2 in 1948, reviewed the literature of 308 reports from 1943 to 1948. Beerman,3 in 1949, summarized the status of penicillin-sensitivity reactions and stated that one of the most frequently reported clinical pictures is that of a serum-sickness-like reaction. The first systematic study of the clinical and immunological phenomenon of serum sickness was done by von Pirquet and Schick4 and was reported in 1905. Cecil5 defines serum sickness as "allergic reaction resulting from the parenteral administration of a foreign serum and characterized by an incubation period, skin eruption, enlargement of lymph nodes, fever, edema and polyarthritis.'' A similar syndrome has been reported as a result of the sulfonamides.6 With the use of antibiotics, syndromes resembling serum sickness have been seen frequently resulting from penicillin. This syndrome has References 1. Keefer, C. S.; Blake, F. G.; Marshall, E. K., Jr.; Lockwood, S., Jr., and Wood, W. B., Jr.: Penicillin in the Treatment of Infections (500 Cases) , J. A. M. A. 122:1217-1224 ( (Aug. 18) ) 1943.Crossref 2. Brown, E. A.: Reactions to Penicillin , Ann. Allergy 6:723-746, 1948. 3. Beerman, H.: Drug Eruptions: A Survey of Recent Literature , Am. J. M. Sc. 218:446, 1949.Crossref 4. von Pirquet, C. F., and Schick, B.: Die Serum Krankheit , Leipzig, F. Deuticke, 1905. 5. Cecil, R. L.: Textbook of Medicine , Philadelphia, W. B. Saunders Company, 1951. 6. Longscope, W. T.: Serum Sickness and Analogous Reactions from Certain Drugs, Particularly the Sulfonamides , Medicine 22:251, 1943. 7. Zussman, B. M.: Severe Serum Sickness Type of Penicillin Reaction: Failure of Antihistamine Therapy , Ann. Allergy 8:751-753, 1950. 8. Hansel, F. K.: Penicillin Sensitivity , Ann. Allergy 7:619 and 624, 1949.

Journal

A.M.A. Archives of Dermatology & SyphilologyAmerican Medical Association

Published: Jun 1, 1952

References