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Serum Protein and Lipoprotein Fractions in Mongolism

Serum Protein and Lipoprotein Fractions in Mongolism Abstract The existence of physical anomalies in mongolism is well known, but the existence of "chemical anomalies" in this condition is not so widely recognized. Stern and Lewis1 and Sobel et al.2 have demonstrated a significantly elevated serum level of gamma globulin and a decrease in albumin in a limited number of mongoloid children. Simon et al.3 have reported lipoprotein abnormalities in children but not in adults with mongolism. The purpose of our study has been to investigate serum protein and lipoprotein fractions in mongolism in a wide age spectrum, from infancy to old age, in adequate numbers in various age groups, in both sexes, and with control of as many environmental factors as possible. Material and Methods The Sonoma State Hospital has 3,700 beds for mentally retarded patients ranging in age from 1 month to over 80 years, with intellectual levels ranging from profound mental deficiency to References 1. Stern, J., and Lewis, W. H. P.: Serum Proteins in Mongolism , J. Ment. Sci. 103:222 ( (Jan.) ) 1957. 2. Sobel, A. E.; Strazzulla, M.; Sherman, B. S.; Elkan, B.; Morgenstern, S. W.; Marius, N., and Meisler, A.: Vitamin A Absorption and Other Blood Composition Studies in Mongolism , Amer. J. Ment. Defic. 62:642 ( (Jan.) ) 1958. 3. Simon, A.; Ludwig, C.; Gofman, J. W., and Crook, G. H.: Metabolic Studies in Mongolism: Serum Protein-Bound Iodine, Cholesterol, and Lipoprotein , Amer. J. Psychiat. 111:139 ( (Aug.) ) 1954. 4. Laurell, H.: Discussion of a Paper on Staining of Lipoproteins ; cited in Ciba Foundation Symposium on Paper Electrophoresis, Boston, Little, Brown & Company, 1956, p. 190. 5. General Procedure for Electrophoretic Separations Using Spinco Model R System, Technical Bulletin No. TB 6052A , Palo Alto, Calif., Spinco Division, Beckman Instruments, Inc., 1958. 6. A Method for Serum Proteins Using Bromphenol Blue Dye in Alcoholic Solution , Tech nical Bulletin No. TB 6050A , Palo Alto, Calif., Spinco Division, Beckman Instruments, Inc., 1958. 7. A Method for Serum Lipoproteins Using Oil Red O Dye , Technical Bulletin No. TB 6043B , Palo Alto, Calif., Spinco Division, Beckman Instruments, Inc., 1958. 8. Weichselbaum, T. E.: An Accurate and Rapid Method for the Determination of Proteins in Small Amounts of Blood Serum and Plasma , Amer. J. Clin. Path. , Technical Section 10:40 ( (March) ) 1946. 9. Walker, H. M., and Lev, J.: Statistical Inference , New York, Henry Holt & Company, Inc., 1954. 10. Petermann, M. L.: Alterations in Plasma Protein Patterns in Disease , in Putnam, F. W.: The Plasma Proteins , Vol. 2, New York, Academic Press, Inc., 1960. 11. Gross, P. A. M.; Gitlin, D., and Janeway, C. A.: The Gamma Globulins and Their Clinical Significance: III. Hypergammaglobulinemia , New Engl. J. Med. 260:121 ( (Jan. 15) ) 1959.Crossref 12. Lindgren, F. T., and Nichols, A. V.: Structure and Function of Human Serum Lipoproteins , in Putnam, F. W.: The Plasma Proteins , Vol. 2, New York, Academic Press, Inc., 1960. 13. Angelopoulos, B., and Bechiakis, G.: Electrophoretic Analysis of Serum Proteins, Lipoproteins, and Glucoproteins in Healthy Newborn Infants, Older Infants, and Children in Greece , J Pediat . 57:66 ( (July) ) 1960.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Serum Protein and Lipoprotein Fractions in Mongolism

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References (16)

Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1961.02080010371012
Publisher site
See Article on Publisher Site

Abstract

Abstract The existence of physical anomalies in mongolism is well known, but the existence of "chemical anomalies" in this condition is not so widely recognized. Stern and Lewis1 and Sobel et al.2 have demonstrated a significantly elevated serum level of gamma globulin and a decrease in albumin in a limited number of mongoloid children. Simon et al.3 have reported lipoprotein abnormalities in children but not in adults with mongolism. The purpose of our study has been to investigate serum protein and lipoprotein fractions in mongolism in a wide age spectrum, from infancy to old age, in adequate numbers in various age groups, in both sexes, and with control of as many environmental factors as possible. Material and Methods The Sonoma State Hospital has 3,700 beds for mentally retarded patients ranging in age from 1 month to over 80 years, with intellectual levels ranging from profound mental deficiency to References 1. Stern, J., and Lewis, W. H. P.: Serum Proteins in Mongolism , J. Ment. Sci. 103:222 ( (Jan.) ) 1957. 2. Sobel, A. E.; Strazzulla, M.; Sherman, B. S.; Elkan, B.; Morgenstern, S. W.; Marius, N., and Meisler, A.: Vitamin A Absorption and Other Blood Composition Studies in Mongolism , Amer. J. Ment. Defic. 62:642 ( (Jan.) ) 1958. 3. Simon, A.; Ludwig, C.; Gofman, J. W., and Crook, G. H.: Metabolic Studies in Mongolism: Serum Protein-Bound Iodine, Cholesterol, and Lipoprotein , Amer. J. Psychiat. 111:139 ( (Aug.) ) 1954. 4. Laurell, H.: Discussion of a Paper on Staining of Lipoproteins ; cited in Ciba Foundation Symposium on Paper Electrophoresis, Boston, Little, Brown & Company, 1956, p. 190. 5. General Procedure for Electrophoretic Separations Using Spinco Model R System, Technical Bulletin No. TB 6052A , Palo Alto, Calif., Spinco Division, Beckman Instruments, Inc., 1958. 6. A Method for Serum Proteins Using Bromphenol Blue Dye in Alcoholic Solution , Tech nical Bulletin No. TB 6050A , Palo Alto, Calif., Spinco Division, Beckman Instruments, Inc., 1958. 7. A Method for Serum Lipoproteins Using Oil Red O Dye , Technical Bulletin No. TB 6043B , Palo Alto, Calif., Spinco Division, Beckman Instruments, Inc., 1958. 8. Weichselbaum, T. E.: An Accurate and Rapid Method for the Determination of Proteins in Small Amounts of Blood Serum and Plasma , Amer. J. Clin. Path. , Technical Section 10:40 ( (March) ) 1946. 9. Walker, H. M., and Lev, J.: Statistical Inference , New York, Henry Holt & Company, Inc., 1954. 10. Petermann, M. L.: Alterations in Plasma Protein Patterns in Disease , in Putnam, F. W.: The Plasma Proteins , Vol. 2, New York, Academic Press, Inc., 1960. 11. Gross, P. A. M.; Gitlin, D., and Janeway, C. A.: The Gamma Globulins and Their Clinical Significance: III. Hypergammaglobulinemia , New Engl. J. Med. 260:121 ( (Jan. 15) ) 1959.Crossref 12. Lindgren, F. T., and Nichols, A. V.: Structure and Function of Human Serum Lipoproteins , in Putnam, F. W.: The Plasma Proteins , Vol. 2, New York, Academic Press, Inc., 1960. 13. Angelopoulos, B., and Bechiakis, G.: Electrophoretic Analysis of Serum Proteins, Lipoproteins, and Glucoproteins in Healthy Newborn Infants, Older Infants, and Children in Greece , J Pediat . 57:66 ( (July) ) 1960.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Sep 1, 1961

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