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SERUM INTERFERON IN ACUTE NONGRANULOMATOUS ANTERIOR UVEITIS

SERUM INTERFERON IN ACUTE NONGRANULOMATOUS ANTERIOR UVEITIS Abstract To the Editor. —In most cases the etiology of nongranulomatous anterior uveitis is obscure. Both infectious and imunological hypersensitivity mechanisms have been postulated. A heretofore undetected virus often is contemplated as the infectious agent.Interferon is a protein produced by virusinfected cells, which acts intracellularly to prevent replication of viruses.1 It can be measured in the serum of patients within 24 hours after viremia2 and usually persists in the serum for about three to five days. Serum interferon has been detected during the early clinical course of several viral infections.4-7 Thus, if uveitis were virus-mediated, it might be possible to measure serum interferon levels in patients with acute nongranulomatous anterior uveitis.I have studied the serum interferon levels of two patients with typical acute, monocular, nongranulomatous anterior uveitis of unknown cause. Neither patient had a history of previous eye disease. Interferon was measured using a modification of References 1. Finkelstein MS, Merigan TC: Interferon-1968: How much do we understand? Calif Med 109:24-34, 1968. 2. Wheelock EF, Sibley WA: Circulating virus, interferon and antibody after vaccination with the 17-D strain of yellow-fever virus . New Eng J Med 273:194-198, 1965.Crossref 3. Petralli JK, Merigan TC, Wilbur JR: Circulating interferon after measles vaccination . New Eng J Med 273:198-201, 1965.Crossref 4. Waddell DJ, Wilbur JR, Merigan TC: Interferon production in human mumps infection . Proc Soc Exp Biol Med 127:320-324, 1968.Crossref 5. Ray CG, Gravelle CR, Chin TDY: Circulating interferon in infants and children with acute respiratory illness . J Pediat 71:27-32, 1967.Crossref 6. Jao RL, Wheelock EF, Jackson GG: Interferon study in volunteers infected with Asian influenza . J Clin Invest 44:1062, 1965. 7. Wheelock EF, Sibley WA: Interferon in human serum during clinical viral infections . Lancet 2:382-385, 1964. 8. Koff RS, Isselbacher KJ: Changing concepts in the epidemiology of viral hepatitis . New Eng J Med 278:1371-1380, 1968.Crossref 9. Prince AM: Antigen detected in blood during incubation period of serum hepatitis . Proc Nat Acad Sci USA 60:814-821, 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

SERUM INTERFERON IN ACUTE NONGRANULOMATOUS ANTERIOR UVEITIS

Archives of Ophthalmology , Volume 84 (2) – Aug 1, 1970

SERUM INTERFERON IN ACUTE NONGRANULOMATOUS ANTERIOR UVEITIS

Abstract

Abstract To the Editor. —In most cases the etiology of nongranulomatous anterior uveitis is obscure. Both infectious and imunological hypersensitivity mechanisms have been postulated. A heretofore undetected virus often is contemplated as the infectious agent.Interferon is a protein produced by virusinfected cells, which acts intracellularly to prevent replication of viruses.1 It can be measured in the serum of patients within 24 hours after viremia2 and usually persists in the serum...
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Publisher
American Medical Association
Copyright
Copyright © 1970 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1970.00990040237020
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —In most cases the etiology of nongranulomatous anterior uveitis is obscure. Both infectious and imunological hypersensitivity mechanisms have been postulated. A heretofore undetected virus often is contemplated as the infectious agent.Interferon is a protein produced by virusinfected cells, which acts intracellularly to prevent replication of viruses.1 It can be measured in the serum of patients within 24 hours after viremia2 and usually persists in the serum for about three to five days. Serum interferon has been detected during the early clinical course of several viral infections.4-7 Thus, if uveitis were virus-mediated, it might be possible to measure serum interferon levels in patients with acute nongranulomatous anterior uveitis.I have studied the serum interferon levels of two patients with typical acute, monocular, nongranulomatous anterior uveitis of unknown cause. Neither patient had a history of previous eye disease. Interferon was measured using a modification of References 1. Finkelstein MS, Merigan TC: Interferon-1968: How much do we understand? Calif Med 109:24-34, 1968. 2. Wheelock EF, Sibley WA: Circulating virus, interferon and antibody after vaccination with the 17-D strain of yellow-fever virus . New Eng J Med 273:194-198, 1965.Crossref 3. Petralli JK, Merigan TC, Wilbur JR: Circulating interferon after measles vaccination . New Eng J Med 273:198-201, 1965.Crossref 4. Waddell DJ, Wilbur JR, Merigan TC: Interferon production in human mumps infection . Proc Soc Exp Biol Med 127:320-324, 1968.Crossref 5. Ray CG, Gravelle CR, Chin TDY: Circulating interferon in infants and children with acute respiratory illness . J Pediat 71:27-32, 1967.Crossref 6. Jao RL, Wheelock EF, Jackson GG: Interferon study in volunteers infected with Asian influenza . J Clin Invest 44:1062, 1965. 7. Wheelock EF, Sibley WA: Interferon in human serum during clinical viral infections . Lancet 2:382-385, 1964. 8. Koff RS, Isselbacher KJ: Changing concepts in the epidemiology of viral hepatitis . New Eng J Med 278:1371-1380, 1968.Crossref 9. Prince AM: Antigen detected in blood during incubation period of serum hepatitis . Proc Nat Acad Sci USA 60:814-821, 1968.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Aug 1, 1970

References