Abstract To the Editor. —We read with interest the article by Azizi entitled "γ-Glutamyl Transpeptidase Levels in Thyroid Disease" in the January Archives (1982;142:79-81). We have studied the serum GGT activity in 24 patients with untreated thyroid diseases—12 with hyperthyroidism (ten female and two male patients, aged 26 to 80 years; mean ± SEM, 58.16 ± 5.23 years) and 12 with hypothyroidism (eight female and four male patients, aged 12 to 70 years; mean ± SEM, 52.66 ± 4.81 years). A group of eight female and four male normal volunteers served as control subjects. Their mean ± SEM age was 35.91 ± 1.92 years. The diagnosis of thyroid disease was based on clinical findings and measurement of serum free thyroxine (T4) index and thyrotropin level. Serum GGT was assayed by a kinetic-spectrophotometric method according to Szasz.1 None of the patients or control subjects with conditions known to modifier serum References 1. Szasz G: Kinetic photometric method for serum γ-glutamyl transpeptidase. Clin Chem 1969;15:124-136. 2. Rosalki SB: γ-glutamyl transpeptidase , in Bodansky O, Latner AL (eds): Advanced Clinical Chemistry . New York, Academic Press Inc, 1975, vol 17, pp 53-107. 3. Lum G, Gambino R: Serum γ-glutamyl transpeptidase activity as an indicator of disease of liver, pancreas, or bone. Clin Chem 1972; 18:358-362.
Archives of Internal Medicine – American Medical Association
Published: May 1, 1983