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Serum β-Carotene, Retinol, and α-Tocopherol Levels During Mineral Oil Therapy for Constipation

Serum β-Carotene, Retinol, and α-Tocopherol Levels During Mineral Oil Therapy for Constipation Abstract • Twenty-five children with chronic constipation underwent serial monitoring of serum β-carotene, retinol (vitamin A1), and α-tocopherol (vitamin E) levels during mineral oil therapy. Mineral oil was administered between meals. Patients were monitored for up to four months of therapy. Mean serum β-carotene levels fell from 1.0±0.5 μmol/L (55.7±26.0 μg/dL) to 0.7±0.4 μmol/L (35.9±22.1 μg/dL) after the first month of mineral oil therapy and remained depressed throughout the remainder of the study. Serum α-tocopherol levels remained unchanged throughout the observation period. There was a modest increase in serum retinol levels during the study, especially after three months (from 1.48±0.84 μmol/L [42.3±24.1 μg/dL] to 2.22±0.77 μmol/L [63.5±22.1 μg/dL]). We conclude that while a short course of mineral oil can induce a reduction in the serum level of β-carotene, the treatment has no adverse effect on serum levels of retinol and α-tocopherol. (AJDC 1987;141:1210-1212) References 1. Davidson M, Kugler MM, Bauer CH: Diagnosis and management in children with severe and protracted constipation and absorption . J Pediatr 1963;62:261-275.Crossref 2. Curtis AC, Kline EM: Influence of liquid petrolatum on the blood content of carotene in human beings . Arch Intern Med 1939;63:54-63.Crossref 3. Javert CT, Macri C: Prothrombin concentration and mineral oil . Am J Obstet Gynecol 1947;42:409-414. 4. Curtis AC, Ballmer RS: The prevention of carotene absorption by liquid petroleum . JAMA 1939;113:1785-1788. 5. Catignani GL, Bieri JG: Simultaneous determination of retinol and α-tocopherol in serum or plasma by liquid chromatography . Clin Chem 1983;29:708-712. 6. Miller KW, Yang CS: An isocratic highperformance liquid chromatography method for the simultaneous analysis of plasma retinol, α-tocopherol, and various carotenoids . Anal Biochem 1985;145:21-26.Crossref 7. Ballantine TVM, Zeigler D, Greecher CP, et al: The effect of mineral oil on fat-soluble vitamin levels, abstracted . JPEN 1986;10:18. 8. Clark JH, Nagamori KE, Ellett ME, et al: Vitamin E sufficiency in children with cholestasis: A comparison between erythrocyte peroxide hemolysis and serum α-tocopherol . Clin Chim Acta 1985;153:117-124.Crossref 9. Dutcher RA, Harris PL, Hartzler ER, et al: Vitamin studies: XIX. The assimilation of carotene and vitamin A in the presence of mineral oil . J Nutr 1934;8:269-283. 10. Mahle AE, Patton HM: Carotene and vitamin A metabolism in man: Their excretion and plasma level as influenced by orally administere[ill] mineral oil and a hydrophilic mucilloid . Gastro[ill] enterology 1947;9:44-53. 11. Isaacs BL, Jung FT, Ivy AC: Clinical stud ies of vitamin A deficiency . Arch Ophthalmol 1940;24:698-721.Crossref 12. Kayden HJ, Hatam LT, Traber MG: The measurement of nanograms of tocopherol from needle aspiration biopsies of adipose tissue: Normal and abetalipoproteinemic subjects . J Lipi[ill] Res 1983;24:652-656. 13. Bunnell RH, De Ritter E, Rubin SH: Effec[ill] of feeding polyunsaturated fatty acids with a low vitamin diet on blood levels of tocopherol in me[ill] performing hard physical labor . Am J Clin Nut[ill] 1975;28:706-711. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Serum β-Carotene, Retinol, and α-Tocopherol Levels During Mineral Oil Therapy for Constipation

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460110080028
Publisher site
See Article on Publisher Site

Abstract

Abstract • Twenty-five children with chronic constipation underwent serial monitoring of serum β-carotene, retinol (vitamin A1), and α-tocopherol (vitamin E) levels during mineral oil therapy. Mineral oil was administered between meals. Patients were monitored for up to four months of therapy. Mean serum β-carotene levels fell from 1.0±0.5 μmol/L (55.7±26.0 μg/dL) to 0.7±0.4 μmol/L (35.9±22.1 μg/dL) after the first month of mineral oil therapy and remained depressed throughout the remainder of the study. Serum α-tocopherol levels remained unchanged throughout the observation period. There was a modest increase in serum retinol levels during the study, especially after three months (from 1.48±0.84 μmol/L [42.3±24.1 μg/dL] to 2.22±0.77 μmol/L [63.5±22.1 μg/dL]). We conclude that while a short course of mineral oil can induce a reduction in the serum level of β-carotene, the treatment has no adverse effect on serum levels of retinol and α-tocopherol. (AJDC 1987;141:1210-1212) References 1. Davidson M, Kugler MM, Bauer CH: Diagnosis and management in children with severe and protracted constipation and absorption . J Pediatr 1963;62:261-275.Crossref 2. Curtis AC, Kline EM: Influence of liquid petrolatum on the blood content of carotene in human beings . Arch Intern Med 1939;63:54-63.Crossref 3. Javert CT, Macri C: Prothrombin concentration and mineral oil . Am J Obstet Gynecol 1947;42:409-414. 4. Curtis AC, Ballmer RS: The prevention of carotene absorption by liquid petroleum . JAMA 1939;113:1785-1788. 5. Catignani GL, Bieri JG: Simultaneous determination of retinol and α-tocopherol in serum or plasma by liquid chromatography . Clin Chem 1983;29:708-712. 6. Miller KW, Yang CS: An isocratic highperformance liquid chromatography method for the simultaneous analysis of plasma retinol, α-tocopherol, and various carotenoids . Anal Biochem 1985;145:21-26.Crossref 7. Ballantine TVM, Zeigler D, Greecher CP, et al: The effect of mineral oil on fat-soluble vitamin levels, abstracted . JPEN 1986;10:18. 8. Clark JH, Nagamori KE, Ellett ME, et al: Vitamin E sufficiency in children with cholestasis: A comparison between erythrocyte peroxide hemolysis and serum α-tocopherol . Clin Chim Acta 1985;153:117-124.Crossref 9. Dutcher RA, Harris PL, Hartzler ER, et al: Vitamin studies: XIX. The assimilation of carotene and vitamin A in the presence of mineral oil . J Nutr 1934;8:269-283. 10. Mahle AE, Patton HM: Carotene and vitamin A metabolism in man: Their excretion and plasma level as influenced by orally administere[ill] mineral oil and a hydrophilic mucilloid . Gastro[ill] enterology 1947;9:44-53. 11. Isaacs BL, Jung FT, Ivy AC: Clinical stud ies of vitamin A deficiency . Arch Ophthalmol 1940;24:698-721.Crossref 12. Kayden HJ, Hatam LT, Traber MG: The measurement of nanograms of tocopherol from needle aspiration biopsies of adipose tissue: Normal and abetalipoproteinemic subjects . J Lipi[ill] Res 1983;24:652-656. 13. Bunnell RH, De Ritter E, Rubin SH: Effec[ill] of feeding polyunsaturated fatty acids with a low vitamin diet on blood levels of tocopherol in me[ill] performing hard physical labor . Am J Clin Nut[ill] 1975;28:706-711.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Nov 1, 1987

References