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Serum Calcium Responses to Exogenous Secretin

Serum Calcium Responses to Exogenous Secretin Abstract Increasing attention is being focused on the relationship between gastrointestinal hormones and calcium metabolism. While it is apparent that some relationship does exist, the exact nature and significance is as yet undefined. Information regarding the effect of secretin on serum calcium has been both sparse and contradictory. Boot's secretin, 3 units/kg, was given to a group of 44 patients consisting of normal controls and patients with duodenal, gastric, and marginal ulcers; primary hyperparathyroidism; and pernicious anemia. Six serial serum specimens were obtained from each patient at ten-minute intervals for calcium determination by atomic absorption spectrophotometry. Using two-way analysis of variance, no significant changes in postsecretin serum calcium values were observed. It is unlikely that physiologic levels of secretin exert any effect on serum calcium. References 1. Care AD, Bates RFL, Gitelman HJ: A possible role for the adenyl cyclase system in calcitonin release . J Endocrinol 48:1-16, 1970.Crossref 2. Care AD, Bruce JB, Boelkins J, et al: Role of pancreozymin-cholecystokinin and structurally related compounds as calcitonin secretagogues . Endocrinology 89:262–271. 1971.Crossref 3. Care AD, Bates RFL, Ganguli PC: The role of gastrin as a calcitonin secretagogue . J Endocrinol 51:735-744, 1971.Crossref 4. Cooper CW, McGuigan JE, Schwesinger WH, et al: Correlation between levels of gastrin and thyrocalcitonin in pig thyroid venous blood . J Endocrinol 95:302-307, 1974.Crossref 5. Gray TK, Munson PL: Thyrocalcitonin: Evidence for physiologic function . Science 166:512-513, 1969.Crossref 6. Swaminathan R, Bates RFL, Bloom SR, et al: The relationship between food, gastrointestinal hormones and calcitonin secretion . J Endocrinol 59:217-230, 1973.Crossref 7. Isenberg JI, Brickman AS, Moore EW: The effect of secretin on serum calcium in man . J Clin Endocrinol Metab 37:30-33, 1973.Crossref 8. Thompson JC, Reeder DD, Bunchman HH, et al: Effect of secretin on circulating gastrin . Ann Surg 176:384-393, 1972.Crossref 9. Reeder DD, Jackson BM, Ban J, et al: Influence of hypercalcemia on gastric secretion and serum gastrin concentrations in man . Ann Surg 72:540-546, 1970.Crossref 10. Sizemore GW, Go VLW, Kaplan EL, et al: Relations of calcitonin and gastrin in the Zollinger-Ellison syndrome and medullary carcinoma of the thyroid . N Engl J Med 288:641-644, 1973.Crossref 11. Birge SJ, Avioli LV: Glucagon-induced hypocalcemia in man . J Clin Endocrinol Metab 29:213-218, 1969.Crossref 12. Bloom SR, Ogawa O: Radioimmunoassay of human peripheral plasma secretin . J Endocrinol 58:xxiv-xxv, 1973. 13. Zimmerman MJ, Dreiling DA, Janowitz HD; The secretin test , in Jorpes JE, Mutt V (eds): Secretin, Cholecystokinin, Pancreozymin and Gastrin . New York, Springer-Verlag, 1973. 14. Konturek SJ: Comparison of pancreatic responses to natural and synthetic secretins in conscious cats . Am J Dig Dis 14:557-565, 1969.Crossref 15. Lehnert P, Stahlheber H, Forrell M, et al: Bestimmung der Halbwertszeit von Secretin . Klin Wochenschr 47:1200-1205, 1969.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Serum Calcium Responses to Exogenous Secretin

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Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1975.01360160059009
Publisher site
See Article on Publisher Site

Abstract

Abstract Increasing attention is being focused on the relationship between gastrointestinal hormones and calcium metabolism. While it is apparent that some relationship does exist, the exact nature and significance is as yet undefined. Information regarding the effect of secretin on serum calcium has been both sparse and contradictory. Boot's secretin, 3 units/kg, was given to a group of 44 patients consisting of normal controls and patients with duodenal, gastric, and marginal ulcers; primary hyperparathyroidism; and pernicious anemia. Six serial serum specimens were obtained from each patient at ten-minute intervals for calcium determination by atomic absorption spectrophotometry. Using two-way analysis of variance, no significant changes in postsecretin serum calcium values were observed. It is unlikely that physiologic levels of secretin exert any effect on serum calcium. References 1. Care AD, Bates RFL, Gitelman HJ: A possible role for the adenyl cyclase system in calcitonin release . J Endocrinol 48:1-16, 1970.Crossref 2. Care AD, Bruce JB, Boelkins J, et al: Role of pancreozymin-cholecystokinin and structurally related compounds as calcitonin secretagogues . Endocrinology 89:262–271. 1971.Crossref 3. Care AD, Bates RFL, Ganguli PC: The role of gastrin as a calcitonin secretagogue . J Endocrinol 51:735-744, 1971.Crossref 4. Cooper CW, McGuigan JE, Schwesinger WH, et al: Correlation between levels of gastrin and thyrocalcitonin in pig thyroid venous blood . J Endocrinol 95:302-307, 1974.Crossref 5. Gray TK, Munson PL: Thyrocalcitonin: Evidence for physiologic function . Science 166:512-513, 1969.Crossref 6. Swaminathan R, Bates RFL, Bloom SR, et al: The relationship between food, gastrointestinal hormones and calcitonin secretion . J Endocrinol 59:217-230, 1973.Crossref 7. Isenberg JI, Brickman AS, Moore EW: The effect of secretin on serum calcium in man . J Clin Endocrinol Metab 37:30-33, 1973.Crossref 8. Thompson JC, Reeder DD, Bunchman HH, et al: Effect of secretin on circulating gastrin . Ann Surg 176:384-393, 1972.Crossref 9. Reeder DD, Jackson BM, Ban J, et al: Influence of hypercalcemia on gastric secretion and serum gastrin concentrations in man . Ann Surg 72:540-546, 1970.Crossref 10. Sizemore GW, Go VLW, Kaplan EL, et al: Relations of calcitonin and gastrin in the Zollinger-Ellison syndrome and medullary carcinoma of the thyroid . N Engl J Med 288:641-644, 1973.Crossref 11. Birge SJ, Avioli LV: Glucagon-induced hypocalcemia in man . J Clin Endocrinol Metab 29:213-218, 1969.Crossref 12. Bloom SR, Ogawa O: Radioimmunoassay of human peripheral plasma secretin . J Endocrinol 58:xxiv-xxv, 1973. 13. Zimmerman MJ, Dreiling DA, Janowitz HD; The secretin test , in Jorpes JE, Mutt V (eds): Secretin, Cholecystokinin, Pancreozymin and Gastrin . New York, Springer-Verlag, 1973. 14. Konturek SJ: Comparison of pancreatic responses to natural and synthetic secretins in conscious cats . Am J Dig Dis 14:557-565, 1969.Crossref 15. Lehnert P, Stahlheber H, Forrell M, et al: Bestimmung der Halbwertszeit von Secretin . Klin Wochenschr 47:1200-1205, 1969.Crossref

Journal

Archives of SurgeryAmerican Medical Association

Published: Oct 1, 1975

References