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Serotonin2A Receptors in Schizophrenia: Relation to Suicide-Reply

Serotonin2A Receptors in Schizophrenia: Relation to Suicide-Reply Abstract In reply The density of 5-HT2 receptors in the frontal cortex of patients with schizophrenia has been reported to be decreased in three studies1-3 and unchanged in four studies.4-7 Obviously, this discrepancy could be due to several factors, such as differences in ligands (iodine 125—labeled LSD vs tritiated ketanserin vs tritiated spiperone), differences in prior medication exposure, or differences in theclinical and demographic characteristics of the patients.In our study, the patients with schizophrenia who died of natural causes had frontal 5-HT2 receptor Bmax values (mean±SEM; n=7, 76±16 fmol/mg of protein) significantly lower than controls (n=13, 164±14 fmol/mg of protein), schizophrenic patients who committed suicide (n=5, 162±25 fmol/mg of protein), and nonschizophrenic suicide victims (n=9, 205±22 fmol/mg of protein). The overall difference among groups was significant (analysis of covariance, P=.006) and the post hoc comparison revealed that the group of patients with schizophrenia who died of References 1. Bennett JP, Enna SJ, Bylund DB, Gillin JC, Wyatt RJ, Snyder SH. Neurotransmitter receptors in frontal cortex of schizophrenics . Arch Gen Psychiatry . 1979;36:927-934.Crossref 2. Mita T, Hanada S, Nishino N, Kuno T, Nakai H, Yamadori T, Mizoi Y, Tanaka C. Decreased serotonin S2 and increased dopamine D2 receptors in chronic schizophrenics . Biol Psychiatry . 1986;21:1407-1414.Crossref 3. Arora RC, Meltzer H. Serotonin (5-HT2) receptor binding in the frontal cortex of schizophrenic patients . J Neural Transm . 1991;815:19-29.Crossref 4. Whitaker PM, Crow TJ, Ferrier IN. Tritiated LSD binding in frontal cortex schizophrenia . Arch Gen Psychiatry . 1981;38:278-280.Crossref 5. Laruelle M, Abi-Dargham A, Casanova MF, Toti R, Weinberger DR, Kleinman JE. Selective abnormalities of prefrontal serotonergic receptors in schizophrenia: a postmortem study . Arch Gen Psychiatry . 1993;50:810-818.Crossref 6. Joyce JN, Shane A, Lexow N, Winokur A, Casanova MF, Kleinman JE. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics . Neuropsychopharmacology . 1993;8:315-336.Crossref 7. Reynolds GP, Rossor MN, Ivesen LL. Preliminary studies of human cortical 5-HT2 receptors and their involvement in schizophrenia and neuroleptic drug action . J Neural Transm . 1984;18( (suppl) ):273-277. 8. Sheldon P, Aghajanian GK. Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: evidence for mediation by 5-HT2 receptors in pyramidal cells and 5-HT1C receptors in interneurons . Synapse . 1991;9:208-218.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Serotonin2A Receptors in Schizophrenia: Relation to Suicide-Reply

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Publisher
American Medical Association
Copyright
Copyright © 1994 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1994.03950120075016
Publisher site
See Article on Publisher Site

Abstract

Abstract In reply The density of 5-HT2 receptors in the frontal cortex of patients with schizophrenia has been reported to be decreased in three studies1-3 and unchanged in four studies.4-7 Obviously, this discrepancy could be due to several factors, such as differences in ligands (iodine 125—labeled LSD vs tritiated ketanserin vs tritiated spiperone), differences in prior medication exposure, or differences in theclinical and demographic characteristics of the patients.In our study, the patients with schizophrenia who died of natural causes had frontal 5-HT2 receptor Bmax values (mean±SEM; n=7, 76±16 fmol/mg of protein) significantly lower than controls (n=13, 164±14 fmol/mg of protein), schizophrenic patients who committed suicide (n=5, 162±25 fmol/mg of protein), and nonschizophrenic suicide victims (n=9, 205±22 fmol/mg of protein). The overall difference among groups was significant (analysis of covariance, P=.006) and the post hoc comparison revealed that the group of patients with schizophrenia who died of References 1. Bennett JP, Enna SJ, Bylund DB, Gillin JC, Wyatt RJ, Snyder SH. Neurotransmitter receptors in frontal cortex of schizophrenics . Arch Gen Psychiatry . 1979;36:927-934.Crossref 2. Mita T, Hanada S, Nishino N, Kuno T, Nakai H, Yamadori T, Mizoi Y, Tanaka C. Decreased serotonin S2 and increased dopamine D2 receptors in chronic schizophrenics . Biol Psychiatry . 1986;21:1407-1414.Crossref 3. Arora RC, Meltzer H. Serotonin (5-HT2) receptor binding in the frontal cortex of schizophrenic patients . J Neural Transm . 1991;815:19-29.Crossref 4. Whitaker PM, Crow TJ, Ferrier IN. Tritiated LSD binding in frontal cortex schizophrenia . Arch Gen Psychiatry . 1981;38:278-280.Crossref 5. Laruelle M, Abi-Dargham A, Casanova MF, Toti R, Weinberger DR, Kleinman JE. Selective abnormalities of prefrontal serotonergic receptors in schizophrenia: a postmortem study . Arch Gen Psychiatry . 1993;50:810-818.Crossref 6. Joyce JN, Shane A, Lexow N, Winokur A, Casanova MF, Kleinman JE. Serotonin uptake sites and serotonin receptors are altered in the limbic system of schizophrenics . Neuropsychopharmacology . 1993;8:315-336.Crossref 7. Reynolds GP, Rossor MN, Ivesen LL. Preliminary studies of human cortical 5-HT2 receptors and their involvement in schizophrenia and neuroleptic drug action . J Neural Transm . 1984;18( (suppl) ):273-277. 8. Sheldon P, Aghajanian GK. Excitatory responses to serotonin (5-HT) in neurons of the rat piriform cortex: evidence for mediation by 5-HT2 receptors in pyramidal cells and 5-HT1C receptors in interneurons . Synapse . 1991;9:208-218.Crossref

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Dec 1, 1994

References