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Serotonin Reuptake Inhibitor Use During Pregnancy

Serotonin Reuptake Inhibitor Use During Pregnancy Letters research has pros and cons, and findings from these 2 alter- herent study design difficulties and small absolute differ- native approaches tend to be complementary. ences, the authors claimed that “we have provided novel Furthermore, while we agree that the inability to control evidence of an association between speech/language disor- for some of the potential confounders was a limitation of our ders in offspring and [serotonin reuptake inhibitor] use dur- study, we are aware that one of the fundamental criteria for a ing pregnancy.” confounding variable is that it should not be affected by At the UCLA Women’s Life Center, we value transparency either the exposure or outcome of interest, and violation of and share new data with our patients. So, what did the Brown this principle would result in overadjustment of the et al article show? Buried in the online Supplement of the 3 1 observed effect size or measure of association. Hence, in article, we learn that the rate of speech/language delay was conducting our study, we were cautious not to inadvertently 1.62% in the serotonin reuptake inhibitor–exposed group vs overadjust the incidence rate ratio estimates by controlling 1.85% in the depression-exposed group compared with 1.04% http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Psychiatry American Medical Association

Serotonin Reuptake Inhibitor Use During Pregnancy

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Publisher
American Medical Association
Copyright
Copyright 2017 American Medical Association. All Rights Reserved.
ISSN
2168-622X
eISSN
2168-6238
DOI
10.1001/jamapsychiatry.2016.4073
pmid
28297012
Publisher site
See Article on Publisher Site

Abstract

Letters research has pros and cons, and findings from these 2 alter- herent study design difficulties and small absolute differ- native approaches tend to be complementary. ences, the authors claimed that “we have provided novel Furthermore, while we agree that the inability to control evidence of an association between speech/language disor- for some of the potential confounders was a limitation of our ders in offspring and [serotonin reuptake inhibitor] use dur- study, we are aware that one of the fundamental criteria for a ing pregnancy.” confounding variable is that it should not be affected by At the UCLA Women’s Life Center, we value transparency either the exposure or outcome of interest, and violation of and share new data with our patients. So, what did the Brown this principle would result in overadjustment of the et al article show? Buried in the online Supplement of the 3 1 observed effect size or measure of association. Hence, in article, we learn that the rate of speech/language delay was conducting our study, we were cautious not to inadvertently 1.62% in the serotonin reuptake inhibitor–exposed group vs overadjust the incidence rate ratio estimates by controlling 1.85% in the depression-exposed group compared with 1.04%

Journal

JAMA PsychiatryAmerican Medical Association

Published: May 15, 2017

References