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Serologic Evidence of Yersinia Infection in Patients With Anterior Uveitis

Serologic Evidence of Yersinia Infection in Patients With Anterior Uveitis Abstract • Anterior uveitis is a common inflammatory eye disease associated with the HLA-B27 phenotype. Bacteriologic cofactors have been implicated in the pathogenesis of several diseases associated with HLA-B27. Using a sensitive enzyme-linked immunosorbent assay, we examined the incidence of previous Yersinia infection in a group of 28 consecutive patients with anterior uveitis. Twelve patients had a significantly increased antibody response to Yersinia, 8 of whom were HLA-B27 positive. Eight patients had IgM antibodies, possibly indicative of recent infection. There were no positive Yersinia serologic findings in our control group of 28 subjects, 13 of whom were HLA-B27 positive. A strong association was found between previous Yersinia infection and the development of anterior uveitis in HLA-B27-positive and HLA-B27-negative patients. References 1. Schlaegel TF Jr. Essentials of Uveitis . New York, NY: Churchill Livingstone Inc; 1969:1-5. 2. Wakefield D, McCluskey PJ, Dunlop I, Penny R. Uveitis: aetiology and disease associations in an Australian population . Aust N Z J Ophthalmol . 1986;14:181-187.Crossref 3. Brewerton DA, Caffrey M, Nicholls A, Walters D, James DCO. Acute anterior uveitis and HLA-27 . Lancet . 1973;2:994-996.Crossref 4. Wakefield D, Easter J, Penny R. Clinical features of HLA-B27 anterior uveitis . Aust N Z J Ophthalmol . 1984;12:191-196.Crossref 5. Mapstone R, Woodrow JC. HLA-27 and acute anterior uveitis . Br J Ophthalmol . 1975;59:270-275.Crossref 6. Ohno S, Kimura SJ, O'Connor GR, Char DH. HLA antigens and uveitis . Br J Ophthalmol . 1975;61:62-64.Crossref 7. Wakefield D, Robinson P, Easter J, Graham D, Penny R. Decreased chemiluminescent associated phagocytic response of peripheral blood mononuclear cells to Chlamydia trachomatis in patients with HLA-B27+ anterior uveitis . Br J Rheumatol . 1985;24:332-339.Crossref 8. Wakefield D, Penny R. Cell-mediated immune response to Chlamydia in anterior uveitis: role of HLA-B27 . Clin Exp Immunol . 1983;51:191-196. 9. Mattila L, Granfors K, Toivanen A. Acute anterior uveitis after Yersinia infection . Br J Ophthalmol . 1982;66:209-212.Crossref 10. Saari KM, Laitinen O, Leirisalo M, Saari R. Ocular inflammation associated with Yersinia infection . Am J Ophthalmol . 1980;89:84-95. 11. Laitinen O, Leirisalo M, Skylv G. Relation between HLA-B27 and clinical features in patients with Yersinia arthritis . Arthritis Rheum . 1977;20:1121-1124.Crossref 12. Leirisalo M, Skylv G, Kousa M, et al. Follow-up study on patients with Reiter's disease and reactive arthritis with special reference to HLA-B27 . Arthritis Rheum . 1982;25:249-259.Crossref 13. Norn M. Uveitis og infektioner med Yersinia enterocolitica . Ugeskr Laeger . 1980;142:829-830. 14. Kay BA, Wachsmuth K, Gemski P, Feeley JC, Quan TJ, Brenner DJ. Virulence and phenotypic characterization of Yersinia enterocolitica isolated from humans in the United States . J Clin Microbiol . 1983;17:128-138. 15. Terasaki P, ed. Histocompatibility Testing 1970 . Copenhagen, Denmark: Munksgaard International Publishers Ltd; 1970:2-27. 16. Kellgren JH. Diagnostic criteria for population studies . Bull Rheum Dis . (November) 1962;13:291. 17. Bennett PH, Burch TA. New York symposium on population studies in the rheumatic diseases: new diagnostic criteria . Bull Rheum Dis . (April) 1967;17:453. 18. Granfors K. Measurement of immunoglobulin M (IgM), IgG, and IgA antibodies against Yersinia enterocolitica by enzyme-linked immunosorbent assay: persistence of serum antibodies during disease . J Clin Microbiol . 1979;9:336-341. 19. Mattila PS, Valtonen V, Tuori MR, Mäkelä O. Antibody response in arthritic and uncomplicated Yersinia enterocolitica infections . J Clin Immunol . (November) 1985;5:404-411.Crossref 20. Ford DK, Henderson E, Price GE, Stein HB. Yersinia-related arthritis in the Pacific north-west . Arthritis Rheum . 1977;20:1226-1230.Crossref 21. Ebringer R, Colthorpe D, Burden G, Hindley C, Ebringer A. Yersinia enterocolitica biotype 1, diarrhoea and episodes of HLA-B27 related ocular and rheumatic inflammatory disease in south-east England . Scand J Rheumatol . 1982;11:171-176.Crossref 22. Mollaret HH. Un domaine pathologique nouveau: l'infection a Yersinia enterocolitica . Ann Biol Clin (Paris) . 1972;30:1-6. 23. Toma S. Survey on the incidence of Yersinia enterocolitica infection in the province of Ontario . Can J Public Health . 1973;64:477-487. 24. Rabson AR, Koornhof HJ. Yersinia enterocolitica infections in South Africa . S Afr Med J . 1972;46:798-803. 25. Zen-Yoji H, Maruyama T. The first successful isolation and identification of Yersinia enterocolitica from human cases in Japan . Jpn J Microbiol . 1972;16:493-500.Crossref 26. Steele TW, McDermott SN. Enterocolitis due to Yersinia enterocolitica in South Australia . Pathology . 1979;11:67-70.Crossref 27. Marriott DJE, Taylor S, Dorman DC. Yersinia enterocolitica infection in children . Med J Aust . 1985;143:489-492. 28. Granfors K, Jalkanen S, von Essen R, et al. Yersinia antigens in synovial-fluid cells from patients with reactive arthritis . N Engl J Med . 1989;320:216-221.Crossref 29. Wakefield D, Breit SN, Clark P, Penny R. Immunogenetic factors in inflammatory eye disease: influence of HLA B27 and alpha 1-antitrypsin phenotypes on disease expression . Arthritis Rheum . 1982;25:1431-1434.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Serologic Evidence of Yersinia Infection in Patients With Anterior Uveitis

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Publisher
American Medical Association
Copyright
Copyright © 1990 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1990.01070040071033
Publisher site
See Article on Publisher Site

Abstract

Abstract • Anterior uveitis is a common inflammatory eye disease associated with the HLA-B27 phenotype. Bacteriologic cofactors have been implicated in the pathogenesis of several diseases associated with HLA-B27. Using a sensitive enzyme-linked immunosorbent assay, we examined the incidence of previous Yersinia infection in a group of 28 consecutive patients with anterior uveitis. Twelve patients had a significantly increased antibody response to Yersinia, 8 of whom were HLA-B27 positive. Eight patients had IgM antibodies, possibly indicative of recent infection. There were no positive Yersinia serologic findings in our control group of 28 subjects, 13 of whom were HLA-B27 positive. A strong association was found between previous Yersinia infection and the development of anterior uveitis in HLA-B27-positive and HLA-B27-negative patients. References 1. Schlaegel TF Jr. Essentials of Uveitis . New York, NY: Churchill Livingstone Inc; 1969:1-5. 2. Wakefield D, McCluskey PJ, Dunlop I, Penny R. Uveitis: aetiology and disease associations in an Australian population . Aust N Z J Ophthalmol . 1986;14:181-187.Crossref 3. Brewerton DA, Caffrey M, Nicholls A, Walters D, James DCO. Acute anterior uveitis and HLA-27 . Lancet . 1973;2:994-996.Crossref 4. Wakefield D, Easter J, Penny R. Clinical features of HLA-B27 anterior uveitis . Aust N Z J Ophthalmol . 1984;12:191-196.Crossref 5. Mapstone R, Woodrow JC. HLA-27 and acute anterior uveitis . Br J Ophthalmol . 1975;59:270-275.Crossref 6. Ohno S, Kimura SJ, O'Connor GR, Char DH. HLA antigens and uveitis . Br J Ophthalmol . 1975;61:62-64.Crossref 7. Wakefield D, Robinson P, Easter J, Graham D, Penny R. Decreased chemiluminescent associated phagocytic response of peripheral blood mononuclear cells to Chlamydia trachomatis in patients with HLA-B27+ anterior uveitis . Br J Rheumatol . 1985;24:332-339.Crossref 8. Wakefield D, Penny R. Cell-mediated immune response to Chlamydia in anterior uveitis: role of HLA-B27 . Clin Exp Immunol . 1983;51:191-196. 9. Mattila L, Granfors K, Toivanen A. Acute anterior uveitis after Yersinia infection . Br J Ophthalmol . 1982;66:209-212.Crossref 10. Saari KM, Laitinen O, Leirisalo M, Saari R. Ocular inflammation associated with Yersinia infection . Am J Ophthalmol . 1980;89:84-95. 11. Laitinen O, Leirisalo M, Skylv G. Relation between HLA-B27 and clinical features in patients with Yersinia arthritis . Arthritis Rheum . 1977;20:1121-1124.Crossref 12. Leirisalo M, Skylv G, Kousa M, et al. Follow-up study on patients with Reiter's disease and reactive arthritis with special reference to HLA-B27 . Arthritis Rheum . 1982;25:249-259.Crossref 13. Norn M. Uveitis og infektioner med Yersinia enterocolitica . Ugeskr Laeger . 1980;142:829-830. 14. Kay BA, Wachsmuth K, Gemski P, Feeley JC, Quan TJ, Brenner DJ. Virulence and phenotypic characterization of Yersinia enterocolitica isolated from humans in the United States . J Clin Microbiol . 1983;17:128-138. 15. Terasaki P, ed. Histocompatibility Testing 1970 . Copenhagen, Denmark: Munksgaard International Publishers Ltd; 1970:2-27. 16. Kellgren JH. Diagnostic criteria for population studies . Bull Rheum Dis . (November) 1962;13:291. 17. Bennett PH, Burch TA. New York symposium on population studies in the rheumatic diseases: new diagnostic criteria . Bull Rheum Dis . (April) 1967;17:453. 18. Granfors K. Measurement of immunoglobulin M (IgM), IgG, and IgA antibodies against Yersinia enterocolitica by enzyme-linked immunosorbent assay: persistence of serum antibodies during disease . J Clin Microbiol . 1979;9:336-341. 19. Mattila PS, Valtonen V, Tuori MR, Mäkelä O. Antibody response in arthritic and uncomplicated Yersinia enterocolitica infections . J Clin Immunol . (November) 1985;5:404-411.Crossref 20. Ford DK, Henderson E, Price GE, Stein HB. Yersinia-related arthritis in the Pacific north-west . Arthritis Rheum . 1977;20:1226-1230.Crossref 21. Ebringer R, Colthorpe D, Burden G, Hindley C, Ebringer A. Yersinia enterocolitica biotype 1, diarrhoea and episodes of HLA-B27 related ocular and rheumatic inflammatory disease in south-east England . Scand J Rheumatol . 1982;11:171-176.Crossref 22. Mollaret HH. Un domaine pathologique nouveau: l'infection a Yersinia enterocolitica . Ann Biol Clin (Paris) . 1972;30:1-6. 23. Toma S. Survey on the incidence of Yersinia enterocolitica infection in the province of Ontario . Can J Public Health . 1973;64:477-487. 24. Rabson AR, Koornhof HJ. Yersinia enterocolitica infections in South Africa . S Afr Med J . 1972;46:798-803. 25. Zen-Yoji H, Maruyama T. The first successful isolation and identification of Yersinia enterocolitica from human cases in Japan . Jpn J Microbiol . 1972;16:493-500.Crossref 26. Steele TW, McDermott SN. Enterocolitis due to Yersinia enterocolitica in South Australia . Pathology . 1979;11:67-70.Crossref 27. Marriott DJE, Taylor S, Dorman DC. Yersinia enterocolitica infection in children . Med J Aust . 1985;143:489-492. 28. Granfors K, Jalkanen S, von Essen R, et al. Yersinia antigens in synovial-fluid cells from patients with reactive arthritis . N Engl J Med . 1989;320:216-221.Crossref 29. Wakefield D, Breit SN, Clark P, Penny R. Immunogenetic factors in inflammatory eye disease: influence of HLA B27 and alpha 1-antitrypsin phenotypes on disease expression . Arthritis Rheum . 1982;25:1431-1434.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Feb 1, 1990

References