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Sensitivity to the Weed Killer DNA-nitralin and Cross-sensitivity to Dinitrochlorobenzene

Sensitivity to the Weed Killer DNA-nitralin and Cross-sensitivity to Dinitrochlorobenzene Abstract • A man, with a dermatitis acquired while working in a factory producing a weed killer, showed sensitivity to 4-methylsulfonyl 2,6-dinitro-N,N-dipropylaniline (DNA-nitralin) and its precursor, 4-chloro 3,-5-dinitrophenylmethyl sulfone (DNC), and cross-sensitivity to dinitrochlorobenzene (DNCB). Sensitization capacities of DNA-nitralin and DNC compared with DNCB, and cross-sensitizations among 11 dinitrobenzene derivatives, including DNA-nitralin, DNC, and DNCB, were studied in guinea pigs. We found that the order of potency was DNCB, DNC, and DNA-nitralin for the sensitization capacity, and that cross-sensitizations may occur among DNCB, DNC, DNA-nitralin, and dinitrofluorobenzene, in comparatively high incidence. (Arch Dermatol 1983;119:304-306) References 1. Magnusson B, Kligman AM: The identification of contact allergens by animal assay: The guinea pig maximization test . J Invest Dermatol 1969;52:268-276. 2. Frenz G, Eiksen K: Treatment of alopecia areata with DNCB: An immunostimulation? Acta Derm Venereol 1977;57:370-371. 3. Happle R, Echternacht K: Induction of hair growth in alopecia areata with DNCB . Lancet 1977;2:1002-1003.Crossref 4. Okabe S, Ogiwara T, Saito H, et al: Rinsho Derma 1979;21:57-62. 5. Schwank VR, Jirasek L: Kontaktallergie gegen Chloramphenicol mit besonderer Berücksichtigung der Gruppensensibilisierung . Hautarzt 1963;14:24-30. 6. Eriksen K: Cross allergy between paranitro compounds with special reference to DNCB and chloramphenicol . Contact Dermatitis 1978;4:29-32.Crossref 7. Djawari D, Körner E, Haneke E: Kreuzallergien nach Sensibilisierung mit Dinitrochlorbenzol (DNCB) . Hautarzt 1980;31:198-202. 8. Garcia-Perez A: Occupational dermatitis from DNFB with cross sensitivity to DNCB . Contact Dermatitis 1978;4:125-127.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Sensitivity to the Weed Killer DNA-nitralin and Cross-sensitivity to Dinitrochlorobenzene

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1983.01650280032011
Publisher site
See Article on Publisher Site

Abstract

Abstract • A man, with a dermatitis acquired while working in a factory producing a weed killer, showed sensitivity to 4-methylsulfonyl 2,6-dinitro-N,N-dipropylaniline (DNA-nitralin) and its precursor, 4-chloro 3,-5-dinitrophenylmethyl sulfone (DNC), and cross-sensitivity to dinitrochlorobenzene (DNCB). Sensitization capacities of DNA-nitralin and DNC compared with DNCB, and cross-sensitizations among 11 dinitrobenzene derivatives, including DNA-nitralin, DNC, and DNCB, were studied in guinea pigs. We found that the order of potency was DNCB, DNC, and DNA-nitralin for the sensitization capacity, and that cross-sensitizations may occur among DNCB, DNC, DNA-nitralin, and dinitrofluorobenzene, in comparatively high incidence. (Arch Dermatol 1983;119:304-306) References 1. Magnusson B, Kligman AM: The identification of contact allergens by animal assay: The guinea pig maximization test . J Invest Dermatol 1969;52:268-276. 2. Frenz G, Eiksen K: Treatment of alopecia areata with DNCB: An immunostimulation? Acta Derm Venereol 1977;57:370-371. 3. Happle R, Echternacht K: Induction of hair growth in alopecia areata with DNCB . Lancet 1977;2:1002-1003.Crossref 4. Okabe S, Ogiwara T, Saito H, et al: Rinsho Derma 1979;21:57-62. 5. Schwank VR, Jirasek L: Kontaktallergie gegen Chloramphenicol mit besonderer Berücksichtigung der Gruppensensibilisierung . Hautarzt 1963;14:24-30. 6. Eriksen K: Cross allergy between paranitro compounds with special reference to DNCB and chloramphenicol . Contact Dermatitis 1978;4:29-32.Crossref 7. Djawari D, Körner E, Haneke E: Kreuzallergien nach Sensibilisierung mit Dinitrochlorbenzol (DNCB) . Hautarzt 1980;31:198-202. 8. Garcia-Perez A: Occupational dermatitis from DNFB with cross sensitivity to DNCB . Contact Dermatitis 1978;4:125-127.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1983

References