Seeing Parkinson Disease in the Retina Invited Commentary Invited Commentary Jonathan B. Lin, MD, PhD; Rajendra S. Apte, MD, PhD Parkinson disease (PD) is a debilitating neurodegenerative dis- agents, and rate of disease progression. If there is indeed a ease caused by progressive death of dopaminergic neurons in difference based on PD subtype, these findings would have the substantia nigra. This neurodegeneration classically causes important implications for improving our ability to counsel a triad of bradykinesia, rigid- patients regarding prognosis. As the authors acknowledge, ity, and rest tremor. Patients given the relatively low discriminative capacity of each of Related article with PD also develop nonmo- these optical coherence tomography (OCT)/OCT angiogra- tor symptoms, such as olfac- phy (OCTA) parameters individually (area under the receiver tory loss, sleep dysfunction, autonomic dysfunction, neuro- operating characteristic curve, 0.50-0.63), these biomarkers psychiatric disturbances, and cognitive impairment. Currently, will likely have to be used in conjunction with existing or PD is diagnosed clinically using the Movement Disorder Soci- other new biomarkers. Future large studies are also neces- ety clinical diagnostic criteria for Parkinson disease. How- sary to help clarify discrepancies between the present find- 5,6 ever, some patients present with atypical features, complicat- ings
JAMA Ophthalmology – American Medical Association
Published: Feb 23, 2021
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