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SECTION OF CORPUS CALLOSUM IN EXPERIMENTAL EPILEPSY IN THE MONKEY

SECTION OF CORPUS CALLOSUM IN EXPERIMENTAL EPILEPSY IN THE MONKEY Abstract THE EFFECT of section of the corpus callosum on human epilepsy remains a controversial issue. Van Wagenen and Herren1 found that in patients with generalized convulsions section of commissural pathways contained in the corpus callosum limited the spread in a unilateral convulsion with no loss of consciousness. Erickson,2 using electrical stimuli, showed that in the monkey section of the corpus callosum played a definite role in the spread of a discharge from one hemisphere to the other. Curtis3 concluded that the typical response to the application of a convulsant drug in monkeys and cats was mediated by the corpus callosum and abolished by its section. Obrador Alcalde,4 studying convulsive attacks produced by electrical stimulation of the cortex in cats, reported that section of the corpus callosum did not change the fundamental character of the convulsions and concluded that the corpus callosum was not an association system References 1. Van Wagenen, W. P., and Herren, R. Y.: Surgical Division of Commissural Pathways in the Corpus Callosum: Relation to Spread of an Epileptic Attack , Arch. Neurol. & Psychiat. 44:740 ( (Oct.) ) 1940. 2. Erickson, T. C.: Spread of the Epileptic Discharge: An Experimental Study of the After-Discharge Induced by Electrical Stimulation of the Cerebral Cortex , Arch. Neurol. & Psychiat. 43:429 ( (March) ) 1940. 3. Curtis, H. J.: Intercortical Connections of the Corpus Callosum as Indicated by Evoked Potentials , J. Neurophysiol. 3:407 ( (Sept.) ) 1940. 4. Obrador Alcalde, S.: Corpus Callosum and Epileptic Fits , Bol. Laborat. estud. méd. méx. 1:29 ( (March) ) 1942. 5. Hoefer, P. E. A., and Pool, J. L.: Conduction of Cortical Impulses and Motor Management of Convulsive Seizures , Arch. Neurol. & Psychiat. 50:381 ( (Oct.) ) 1943. 6. Kopeloff, L. M.; Barrera, S. E., and Kopeloff, N.: Recurrent Convulsive Seizures in Animals Produced by Immunologic and Chemical Means , Am. J. Psychiat. 98:881 ( (May) ) 1942. 7. Kopeloff, N.; Kopeloff, L. M., and Pacella, B. L.: The Experimental Production of Epilepsy in Animals , in Hoch, P. H., and Knight, R. P.: Epilepsy: The Psychiatric Aspects of Convulsive Disorders , New York, Grune & Stratton, Inc., 1947, p. 163. 8. The preparation used was a mixture of hydrous aluminum oxides. 9. Pacella, B. L.; Kopeloff, N.; Barrera, S. E., and Kopeloff, L. M.: Experimental Production of Focal Epilepsy , Arch. Neurol. & Psychiat. 52:189 ( (Sept) .) 1944. 10. Pope, A.; Morris, A. A.; Jasper, H.; Elliott, K. A. C., and Penfield, W.: Histochemical and Action Potential Studies on Epileptogenic Areas of Cerebral Cortex in Man and the Monkey , A. Research Nerv. & Ment. Dis., Proc. 26:218, 1946. 11. von Bonin, G., and Bailey, P.: The Neocortex of Macaca Mulatta, Illinois Monographs in the Medical Sciences , Urbana, Ill., University of Illinois Press, 1948, vol. 4, no. 4. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology & Psychiatry American Medical Association

SECTION OF CORPUS CALLOSUM IN EXPERIMENTAL EPILEPSY IN THE MONKEY

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Publisher
American Medical Association
Copyright
Copyright © 1950 American Medical Association. All Rights Reserved.
ISSN
0096-6754
DOI
10.1001/archneurpsyc.1950.02310230041003
Publisher site
See Article on Publisher Site

Abstract

Abstract THE EFFECT of section of the corpus callosum on human epilepsy remains a controversial issue. Van Wagenen and Herren1 found that in patients with generalized convulsions section of commissural pathways contained in the corpus callosum limited the spread in a unilateral convulsion with no loss of consciousness. Erickson,2 using electrical stimuli, showed that in the monkey section of the corpus callosum played a definite role in the spread of a discharge from one hemisphere to the other. Curtis3 concluded that the typical response to the application of a convulsant drug in monkeys and cats was mediated by the corpus callosum and abolished by its section. Obrador Alcalde,4 studying convulsive attacks produced by electrical stimulation of the cortex in cats, reported that section of the corpus callosum did not change the fundamental character of the convulsions and concluded that the corpus callosum was not an association system References 1. Van Wagenen, W. P., and Herren, R. Y.: Surgical Division of Commissural Pathways in the Corpus Callosum: Relation to Spread of an Epileptic Attack , Arch. Neurol. & Psychiat. 44:740 ( (Oct.) ) 1940. 2. Erickson, T. C.: Spread of the Epileptic Discharge: An Experimental Study of the After-Discharge Induced by Electrical Stimulation of the Cerebral Cortex , Arch. Neurol. & Psychiat. 43:429 ( (March) ) 1940. 3. Curtis, H. J.: Intercortical Connections of the Corpus Callosum as Indicated by Evoked Potentials , J. Neurophysiol. 3:407 ( (Sept.) ) 1940. 4. Obrador Alcalde, S.: Corpus Callosum and Epileptic Fits , Bol. Laborat. estud. méd. méx. 1:29 ( (March) ) 1942. 5. Hoefer, P. E. A., and Pool, J. L.: Conduction of Cortical Impulses and Motor Management of Convulsive Seizures , Arch. Neurol. & Psychiat. 50:381 ( (Oct.) ) 1943. 6. Kopeloff, L. M.; Barrera, S. E., and Kopeloff, N.: Recurrent Convulsive Seizures in Animals Produced by Immunologic and Chemical Means , Am. J. Psychiat. 98:881 ( (May) ) 1942. 7. Kopeloff, N.; Kopeloff, L. M., and Pacella, B. L.: The Experimental Production of Epilepsy in Animals , in Hoch, P. H., and Knight, R. P.: Epilepsy: The Psychiatric Aspects of Convulsive Disorders , New York, Grune & Stratton, Inc., 1947, p. 163. 8. The preparation used was a mixture of hydrous aluminum oxides. 9. Pacella, B. L.; Kopeloff, N.; Barrera, S. E., and Kopeloff, L. M.: Experimental Production of Focal Epilepsy , Arch. Neurol. & Psychiat. 52:189 ( (Sept) .) 1944. 10. Pope, A.; Morris, A. A.; Jasper, H.; Elliott, K. A. C., and Penfield, W.: Histochemical and Action Potential Studies on Epileptogenic Areas of Cerebral Cortex in Man and the Monkey , A. Research Nerv. & Ment. Dis., Proc. 26:218, 1946. 11. von Bonin, G., and Bailey, P.: The Neocortex of Macaca Mulatta, Illinois Monographs in the Medical Sciences , Urbana, Ill., University of Illinois Press, 1948, vol. 4, no. 4.

Journal

Archives of Neurology & PsychiatryAmerican Medical Association

Published: May 1, 1950

References