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Schizophrenia: Evidence of a Subgroup With Reversed Cerebral Asymmetry

Schizophrenia: Evidence of a Subgroup With Reversed Cerebral Asymmetry Abstract • Normal right-handed individuals often show neuroanatomical asymmetries of the brain on computed tomography (CT), with wider right frontal and left occipital lobes. We examined the frequency of reversals of this normal asymmetry in a group of 57 right-handed schizophrenic patients. Compared to 80 normal right-handers, the schizophrenics had an increased frequency of both frontal and occipital reversals. We then divided the patients on the basis of whether they had CT evidence suggestive of brain atrophy. Those without evidence of atrophy had increased frontal and occipital reversals. Those with evidence of atrophy had no increase in reversals. This suggests that reversals of neuroanatomical asymmetry, and by implication abnormalities of lateralization, are relevant to a subgroup of schizophrenic patients with otherwise normal CT scans. References 1. Galaburda AM, LeMay M, Kenger TL, et al: Right-Left asymmetries in the brain . Science 199:852-856, 1978.Crossref 2. LeMay M: Morphological cerebral asymmetries of modern man, fossil man, and nonhuman primates . Ann NY Acad Sci 280:349-366, 1976.Crossref 3. LeMay M, Kido DK: Asymmetries of cerebral hemispheres on computed tomograms . J Comput Assist Tomogr 2:471-476, 1978.Crossref 4. Hier DB, LeMay M, Rosenberger PB: Autism: Association with reversed cerebral asymmetry . Neurology 28:348-349, 1978a. 5. Rosenberger PB, Hier DB, Epstein A: Cerebral Asymmetry in Children With Delayed Speech . Denver, Child Neurology Society, 1978. 6. Hier DB, LeMay M, Rosenberger PB, et al: Developmental dyslexia: Evidence for a subgroup with a reversal of cerebral asymmetry . Arch Neurol 35:90-92, 1978.Crossref 7. Rosenberger PB, Hier DB: Cerebral asymmetry and verbal intellectual deficits . Neurology 29:544, 1979. 8. Flor-Henry P: The endogenous psychoses: A reflection of lateralized dysfunction of the anterior limbic system , in Livingston KE, Hornykiewics 0 (eds): The Limbic System Concept . New York, Plenum Press Inc, 1978. 9. Spitzer RL, Endicott J, Robins E: Research Diagnostic Criteria (RDC) for a Selected Group of Funtional Disorders , ed 3. New York, New York Psychiatric Institute, 1977. 10. Zamora EN, Kaelbing R: Memory and electroconvulsive therapy . Am J Psychiatry 122:546-554, 1965. 11. Weinberger DR, Torrey EF, Neophytides AN, et al: Lateral cerebral ventricular enlargement in chronic schizophrenia . Arch Gen Psychiatry 36:735-739, 1979.Crossref 12. Weinberger DR, Torrey EF, Neophytides AN, et al: Structural abnormalities in the cerebral cortex of chronic schizophrenic patients . Arch Gen Psychiatry 36:935-939, 1979.Crossref 13. Weinberger DR, Torrey EF, Wyatt RJ: Cases of cerebellar atrophy in a group of chronic schizophrenic patients . Lancet 1:718, 1979.Crossref 14. Oddy HC, Lobstein TJ: Hand and eye dominance in schizophrenia . Br J Psychiatry 120:331-332, 1972.Crossref 15. Gur RE: Cognitive concomitants of hemispheric dysfunction in schizophrenia . Arch Gen Psychiatry 36:269-274, 1979.Crossref 16. Blau TH: Torque and schizophrenic vulnerability: As the world turns . Am Psychol 32:997-1005, 1977.Crossref 17. Luchins DJ, Torrey EF, Weinberger DR, et al: HLA antigens in schizophrenia: Differences between patients with and without brain atrophy . Br J Psychiatry , to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of General Psychiatry American Medical Association

Schizophrenia: Evidence of a Subgroup With Reversed Cerebral Asymmetry

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Publisher
American Medical Association
Copyright
Copyright © 1979 American Medical Association. All Rights Reserved.
ISSN
0003-990X
eISSN
1598-3636
DOI
10.1001/archpsyc.1979.01780120039005
Publisher site
See Article on Publisher Site

Abstract

Abstract • Normal right-handed individuals often show neuroanatomical asymmetries of the brain on computed tomography (CT), with wider right frontal and left occipital lobes. We examined the frequency of reversals of this normal asymmetry in a group of 57 right-handed schizophrenic patients. Compared to 80 normal right-handers, the schizophrenics had an increased frequency of both frontal and occipital reversals. We then divided the patients on the basis of whether they had CT evidence suggestive of brain atrophy. Those without evidence of atrophy had increased frontal and occipital reversals. Those with evidence of atrophy had no increase in reversals. This suggests that reversals of neuroanatomical asymmetry, and by implication abnormalities of lateralization, are relevant to a subgroup of schizophrenic patients with otherwise normal CT scans. References 1. Galaburda AM, LeMay M, Kenger TL, et al: Right-Left asymmetries in the brain . Science 199:852-856, 1978.Crossref 2. LeMay M: Morphological cerebral asymmetries of modern man, fossil man, and nonhuman primates . Ann NY Acad Sci 280:349-366, 1976.Crossref 3. LeMay M, Kido DK: Asymmetries of cerebral hemispheres on computed tomograms . J Comput Assist Tomogr 2:471-476, 1978.Crossref 4. Hier DB, LeMay M, Rosenberger PB: Autism: Association with reversed cerebral asymmetry . Neurology 28:348-349, 1978a. 5. Rosenberger PB, Hier DB, Epstein A: Cerebral Asymmetry in Children With Delayed Speech . Denver, Child Neurology Society, 1978. 6. Hier DB, LeMay M, Rosenberger PB, et al: Developmental dyslexia: Evidence for a subgroup with a reversal of cerebral asymmetry . Arch Neurol 35:90-92, 1978.Crossref 7. Rosenberger PB, Hier DB: Cerebral asymmetry and verbal intellectual deficits . Neurology 29:544, 1979. 8. Flor-Henry P: The endogenous psychoses: A reflection of lateralized dysfunction of the anterior limbic system , in Livingston KE, Hornykiewics 0 (eds): The Limbic System Concept . New York, Plenum Press Inc, 1978. 9. Spitzer RL, Endicott J, Robins E: Research Diagnostic Criteria (RDC) for a Selected Group of Funtional Disorders , ed 3. New York, New York Psychiatric Institute, 1977. 10. Zamora EN, Kaelbing R: Memory and electroconvulsive therapy . Am J Psychiatry 122:546-554, 1965. 11. Weinberger DR, Torrey EF, Neophytides AN, et al: Lateral cerebral ventricular enlargement in chronic schizophrenia . Arch Gen Psychiatry 36:735-739, 1979.Crossref 12. Weinberger DR, Torrey EF, Neophytides AN, et al: Structural abnormalities in the cerebral cortex of chronic schizophrenic patients . Arch Gen Psychiatry 36:935-939, 1979.Crossref 13. Weinberger DR, Torrey EF, Wyatt RJ: Cases of cerebellar atrophy in a group of chronic schizophrenic patients . Lancet 1:718, 1979.Crossref 14. Oddy HC, Lobstein TJ: Hand and eye dominance in schizophrenia . Br J Psychiatry 120:331-332, 1972.Crossref 15. Gur RE: Cognitive concomitants of hemispheric dysfunction in schizophrenia . Arch Gen Psychiatry 36:269-274, 1979.Crossref 16. Blau TH: Torque and schizophrenic vulnerability: As the world turns . Am Psychol 32:997-1005, 1977.Crossref 17. Luchins DJ, Torrey EF, Weinberger DR, et al: HLA antigens in schizophrenia: Differences between patients with and without brain atrophy . Br J Psychiatry , to be published.

Journal

Archives of General PsychiatryAmerican Medical Association

Published: Nov 1, 1979

References