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SCARLET FEVER IMMUNIZATION

SCARLET FEVER IMMUNIZATION INTEREST in scarlet fever immunization recently has been slight because of the present mildness of the disease and its favorable response to chemotherapy and antibiotic substances, and because the number of immunizing injections required has been large and not infrequently accompanied with general reactions. New types of antigens that require fewer injections and give only negligible reactions have reawakened interest in scarlet fever immunization. The antigen used in this study was a refined, tannic acid–precipitated, aluminum hydroxide–resuspended scarlet fever streptococcus toxin U.S.P.1 that contains one-tenth the alum of alum-precipitated toxoids. This preparation is more stable than the material stabilized with pectin or acacia. Three injections of 0.1 cc. each were given at monthly intervals. The doses were as follows: For children First 750 Second 3,000 Third 10,000 For adults First 500 Second 2,000 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1947 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1947.02030010729006
Publisher site
See Article on Publisher Site

Abstract

INTEREST in scarlet fever immunization recently has been slight because of the present mildness of the disease and its favorable response to chemotherapy and antibiotic substances, and because the number of immunizing injections required has been large and not infrequently accompanied with general reactions. New types of antigens that require fewer injections and give only negligible reactions have reawakened interest in scarlet fever immunization. The antigen used in this study was a refined, tannic acid–precipitated, aluminum hydroxide–resuspended scarlet fever streptococcus toxin U.S.P.1 that contains one-tenth the alum of alum-precipitated toxoids. This preparation is more stable than the material stabilized with pectin or acacia. Three injections of 0.1 cc. each were given at monthly intervals. The doses were as follows: For children First 750 Second 3,000 Third 10,000 For adults First 500 Second 2,000

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Dec 1, 1947

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