Abstract A total of 141 cases of sarcoidosis have been reviewed. Negroes constituted three quarters of the cases while comprising only one third of the clinic population. The disease was seen three times as frequently in the female as in the male. Over one half of the Negro patients were born in the Southeastern United States and about one third in the Northeastern section of the country. In the white group, sarcoidosis was quite common in Puerto Ricans and rare in individuals born in the continental United States. Age of onset was somewhat earlier in the Negro patients. While no marked racial differences were uncovered, hepatic, splenic, and ocular involvement, hypercalcemia, and hyperproteinemia (especially hypergammaglobulinemia) were somewhat more frequent in the Negro. The course of the disease was not affected by the presence or absence of skin lesions. On the whole the prognosis tended to be better in the white group. Tuberculosis was a surprisingly uncommon complication. References 1. References 18, 19, 21, 24, 25, 28-32. 2. References 14, 18, 19, 21, 25, 27, 29-31, 33, 36. 3. References 14, 16, 17, 20, 27, 36, 38, 39. 4. Herbeuval, R., et al: A propos de 3 cas de maladie de Hodgkins a debut atypique rapport avec la maladie de Besnier-Boeck-Schaumann , Rev Med Nancy 85:762, 1960. 5. Dureux, J. B., et al: Leucose et sarcoidose , Rev Med Nancy 85:778, 1960. 6. Hurley, H. J., and Shelley, W. B.: Sarcoid Granulomas After Intradermal Tuberculin in Normal Human Skin , Arch Derm 82:65, 1960.Crossref 7. Rosenthal, S. R.: Pathological and Experimental Studies of Boeck's Sarcoid , Amer Rev Tuberc 60:236, 1949. 8. Rich, A. R.: The Occurrence of Focal Tuberculoid Lesions in Experimental Serum Sickness , Bull Hopkins Hosp 91:109, 1952. 9. Shelley, W. B., and Hurley, H. J., Jr.: Experimental Sarcoid Reactions in Human Skin , Amer Rev Resp Dis 84 (pt (2) ):45, 1961. 10. Kooij, R.; Pepler, W. J.; and Wainwright, J.: Histopathology of the Reaction Papules Evoked by Intradermal Injection of Normal Tissue Suspensions and Kveim Antigen , Dermatologica (Basel) 119:105, 1959.Crossref 11. Hurley, H. J., and Shelley, W. B.: Comparison of the Granuloma Producing Capacity of Normals and Sarcoid Granuloma Patients: Experimental Analysis of the Sarcoid Diathesis Theory , Amer J Med Sci 237:685, 1959.Crossref 12. Cummings, M. M., and Hudgins, P. C.: Chemical Constituents of Pine Pollen and Their Possible Relationship to Sarcoidosis , Amer J Med Sci 236:311, 1958.Crossref 13. Jackson, A., and Kass, I.: The Relationship Between Periarteritis Nodosa and Sarcoidosis , Ann Intern Med 38:288, 1953.Crossref 14. Anderson, R., et al: Local Sarcoid-Tissue Reactions , Lancet 1:1211, 1962.Crossref 15. Abeles, H.; Robins, A. B.; and Chaves, A. D.: Sarcoidosis in New York City , Amer Rev Resp Dis 84 (pt (2) ):120, 1961. 16. Carr, D. T., and Gage, R. P.: The Prognosis of Sarcoidosis , Amer Rev Tuberc 69:78, 1954. 17. Cooch, J. W.: Sarcoidosis in the US Army, 1952 Through 1956 , Amer Rev Resp Dis 84 (pt (2) ): 103, 1961. 18. Cummings, M. M.; Dunner, E.; and Williams, J. H., Jr.: Epidemiologic and Clinical Observations in Sarcoidosis , Ann Intern Med 50:879, 1959.Crossref 19. Gentry, J. T.; Nitowsky, H. M.; and Michael, M., Jr.: Studies on the Epidemiology of Sarcoidosis in the United States , J Clin Invest 34:1839, 1955.Crossref 20. Gundelfinger, B. F., and Britten, S. A.: Sarcoidosis in the US Navy , Amer Rev Resp Dis 84 (pt (2) ):109, 1961. 21. Sones, M., and Israel, H. L.: Course and Prognosis of Sarcoidosis , Amer J Med 29:84, 1960.Crossref 22. Loncope, W. T., and Freiman, D. G.: A Study of Sarcoidosis , Medicine 31:1, 1952.Crossref 23. Michael, M., Jr., et al: Sarcoidosis , Amer Rev Tuberc 62:403, 1950. 24. Riley, E. A.; Boeck's Sarcoid: Review Based Upon a Clinical Study of 52 Cases , Amer Rev Tuberc 62:231, 1950. 25. Reisner, D.: Boeck's Sarcoid and Systemic Sarcoidosis: Study of 35 Cases (2 parts) , Amer Rev Tuberc 49:289, 437, 1944. 26. Thomas, C. C.: Sarcoidosis , Arch Derm Syph 47:58, 1943.Crossref 27. Terris, M., et al: Incidence of Diagnosed Sarcoidosis in Louisiana , Amer Rev Resp Dis 87: 509, 1963. 28. Mayock, R. L., et al: Manifestations of Sarcoidosis , Amer J Med 35:67, 1963.Crossref 29. Nelson, C. T., and Schwimmer, B.: The Specificity of the Kveim Reaction , J Invest Derm 28:55, 1957. 30. Ricker, W., and Clark, M.: Sarcoidosis , Amer J Clin Path 19:725, 1949. 31. Douglas, A. C.: Sarcoidosis in Scotland , Amer Rev Resp Dis 84 (pt (2) ):143, 1961. 32. Hedvall, E.: Prognosis of Sarcoidosis , Acta Tuberc Scand 39:249, 1960. 33. Lofgren, S., and Stravenow, C.: Course and Prognosis of Sarcoidosis: Stockholm , Amer Rev Resp Dis 84 (pt (2) ):71, 1961. 34. Scadding, J. G.: Discussion on Sarcoidosis , Proc Roy Soc Med 49:799, 1956. 35. Siltzbach, L. E.: Pulmonary Sarcoidosis , Amer J Surg 89:556, 1955.Crossref 36. Nobechi, K.: Epidemiology of Sarcoidosis in Japan , Amer Rev Resp Dis 84 (pt (2) ):148, 1961. 37. Van Lingen, B.: Sarcoidosis in South Africa , Amer Rev Resp Dis 84 (pt (2) ):162, 1961. 38. Nitter, L.: Changes in the Chest Roentgenogram in Boeck's Sarcoid of the Lungs , Acta Radiol (Stockholm) ( (Suppl) ) 105:1, 1953. 39. Sones, M., and Israel, H. L.: Sarcoidosis , Bibl Tuberc 16:214, 1961. 40. James, D. G.: Dermatological Aspects of Sarcoidosis , Quart J Med 28:109, 1959. 41. Israel, H. L., and Sones, M.: Sarcoidosis: Clinical Observation on 160 Cases , Arch Intern Med 102:766, 1958.Crossref 42. Michael, M., Jr.: Sarcoidosis: Some Concepts of Etiology and Diagnosis , Dis Chest 26: 452, 1954.Crossref 43. Rawnsley, H. M.; Yonan, V. L.; and Reinhold, J. G.: Serum Protein Concentrations in the North American Negroid , Science 123:991, 1956.Crossref 44. Comens, P.: Racial Variation in Serum Globulins , Amer J Med Sci 23:275, 1957.Crossref 45. Keltz, H., and Comstock, G. W.: Serum Globulin Levels in Whites and Negroes , New Eng J Med 260:1268, 1959.Crossref 46. Moriyama, I. M.: Mortality From Sarcoidosis in the United States , Torax 9:210, 1960.
Archives of Dermatology – American Medical Association
Published: May 1, 1964
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