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Salve for the Aching Heart

Salve for the Aching Heart After 20 years of undeserved neglect, nitroglycerin ointment is now coming into its own. The need for it is obvious. Sublingually administered nitroglycerin, with its fleeting effect, is inadequate for unstable nocturnal or variant angina. Long-acting nitroglycerin preparations for oral administration lose much of their effectiveness through inactivation of nitrate in the liver. In bypassing the portal circulation, nitroglycerin ointment offers a logical alternative. That the alternative is also practical has been confirmed by recent clinical trials. Reichek and associates1 reported gratifying subjective and objective results with the use of this ointment. Not only was angina forestalled in the 14 patients they studied, but there was a substantial enhancement of exercise capacity, lowering of systolic blood pressure, increase in heart rate, and diminution of exerciseinduced ST segment depression. These effects, which lasted three to five hours, were undiminished after a three-month trial in six of these patients. No evidence http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Salve for the Aching Heart

Vaisrub, Samuel
JAMA , Volume 236 (3) – Jul 19, 1976
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References (3)

Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1976.03270030046031
Publisher site
See Article on Publisher Site

Abstract

After 20 years of undeserved neglect, nitroglycerin ointment is now coming into its own. The need for it is obvious. Sublingually administered nitroglycerin, with its fleeting effect, is inadequate for unstable nocturnal or variant angina. Long-acting nitroglycerin preparations for oral administration lose much of their effectiveness through inactivation of nitrate in the liver. In bypassing the portal circulation, nitroglycerin ointment offers a logical alternative. That the alternative is also practical has been confirmed by recent clinical trials. Reichek and associates1 reported gratifying subjective and objective results with the use of this ointment. Not only was angina forestalled in the 14 patients they studied, but there was a substantial enhancement of exercise capacity, lowering of systolic blood pressure, increase in heart rate, and diminution of exerciseinduced ST segment depression. These effects, which lasted three to five hours, were undiminished after a three-month trial in six of these patients. No evidence

Journal

JAMA – American Medical Association

Published: Jul 19, 1976

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