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Safe Immunization of Allergic Children Against Measles, Mumps, and Rubella

Safe Immunization of Allergic Children Against Measles, Mumps, and Rubella Abstract • A series of 135 subjects (134 children and one adult) with documented or suspected systemic allergy were pricktested before a measles, mumps, and rubella (MMR) vaccination. Atopic eczema was documented in 68, asthma in 47, and cow's-milk allergy in 11 examinees; eight children were evaluated because of severe systemic reactions following diphtheria-pertussis-tetanus, measles, or inactivated polio (Salk) vaccinations. In one child, there was only a suspicion of general allergy. The undiluted MMR prick test gave negative reactions in 126 cases (93%). The highest rate of nonreactivity was observed in those with atopic eczema (96%) and in children with asthma (91%) or cow's-milk allergy (82%). All examinees with systemic reactions after other vaccinations also had negative prick-test reactions. A total of 122 (95%) of the 129 examinees were eventually vaccinated with MMR. No untoward reactions developed, except mild generalized urticaria or fever in two vaccinees. We conclude that at least 95% of children with common forms of systemic allergy can be vaccinated safely with MMR and, In general, that allergic diseases should not interfere with execution of the vaccination programs. (AJDC 1987;141:1103-1105) References 1. Haahtela T: The prevalence of allergic conditions and immediate skin test reactions among Finnish adolescents . Clin Allergy 1979;9:53-60.Crossref 2. Slavin RG, Smith LJ: Epidemiologicconsiderations in atopic disease , in Bierman CW, Pearlman DS (eds): Allergic Diseases of Infancy, Childhood and Adolescence . Philadelphia, WB Saunders Co, 1980, pp 165-172. 3. Peltola H, Karanko V, Kurki T, et al: Rapid effect on endemic measles, mumps and rubella of nationwide vaccination programme in Finland . Lancet 1986;1:137-139.Crossref 4. Buynak EB, Weibel RE, Whitman JE, et al: Combined live measles, mumps, and rubella virus vaccines . JAMA 1969;207:2259-2262.Crossref 5. Weibel RE, Carlson AJ Jr, Villarejos VM, et al: Clinical and laboratory studies of combined live measles, mumps, and rubella vaccinees using the RA 27/3 rubella virus (40979) . Proc Soc Exp Biol Med 1980;165:323-326.Crossref 6. Immunization Practices Advisory Committee: Measles prevention . MMWR 1982;31:217-231. 7. Kamin PB, Fein BT, Britton HA: Use of live, attenuated measles virus vaccine in children allergic to egg protein . JAMA 1965;195:143-144. 8. Aukrust JB, Almeland TL, Rafsum D, et al: Severe hypersensitivity or intolerance reactions to measles vaccine in six children: Clinical and immunological studies . Allergy 1980;35:581-587.Crossref 9. Nieburg PI, Preblud SR, Halsey BA, et al: Measles vaccine in egg-allergic children . Pediatrics 1980;65:365-366. 10. Klein JD (ed): Report of the Committee on Infectious Diseases . Evanston, Ill, American Academy of Pediatrics, 1982. 11. Hermann JJ, Radin R, Schneiderman R: Allergic reactions to measles (rubeola) vaccine in patients hypersensitive to egg protein . J Pediatr 1983;102:196-199.Crossref 12. Rachelefsky GS, Jacobs AH: Atopic dermatitis , in Bierman CW, Pearlman DS (eds): Allergic Diseases of Infancy, Childhood and Adolescence . Philadelphia, WB Saunders Co, 1980, pp 410-430. 13. Savilahti E: Cow's milk allergy . Allergy 1981;36:73-88.Crossref 14. Gavani UD, Hyde JS, Moore BS: Hypersensitivity to milk and egg white: Skin tests, RAST results and clinical intolerance . Ann Allergy 1978;40:314-318. 15. Norman PS: In vivo methods of study of allergy , in Middleton E Jr, Reed CE, Ellis EF (eds): Allergy, Principles and Practice . St Louis, CV Mosby Co, 1978, pp 256-264. 16. Bierman CW, Shapiro GG, Pierson WE, et al: Safety of influenza vaccination in allergic children . J Infect Dis 1977;136( (suppl) ):652-655.Crossref 17. Miller JR, Orgel HA, Meltzer EO: The safety of egg-containing vaccines for egg allergic patients . J Allergy Clin Immunol 1983;7: 568-573. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Safe Immunization of Allergic Children Against Measles, Mumps, and Rubella

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Publisher
American Medical Association
Copyright
Copyright © 1987 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1987.04460100081032
Publisher site
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Abstract

Abstract • A series of 135 subjects (134 children and one adult) with documented or suspected systemic allergy were pricktested before a measles, mumps, and rubella (MMR) vaccination. Atopic eczema was documented in 68, asthma in 47, and cow's-milk allergy in 11 examinees; eight children were evaluated because of severe systemic reactions following diphtheria-pertussis-tetanus, measles, or inactivated polio (Salk) vaccinations. In one child, there was only a suspicion of general allergy. The undiluted MMR prick test gave negative reactions in 126 cases (93%). The highest rate of nonreactivity was observed in those with atopic eczema (96%) and in children with asthma (91%) or cow's-milk allergy (82%). All examinees with systemic reactions after other vaccinations also had negative prick-test reactions. A total of 122 (95%) of the 129 examinees were eventually vaccinated with MMR. No untoward reactions developed, except mild generalized urticaria or fever in two vaccinees. We conclude that at least 95% of children with common forms of systemic allergy can be vaccinated safely with MMR and, In general, that allergic diseases should not interfere with execution of the vaccination programs. (AJDC 1987;141:1103-1105) References 1. Haahtela T: The prevalence of allergic conditions and immediate skin test reactions among Finnish adolescents . Clin Allergy 1979;9:53-60.Crossref 2. Slavin RG, Smith LJ: Epidemiologicconsiderations in atopic disease , in Bierman CW, Pearlman DS (eds): Allergic Diseases of Infancy, Childhood and Adolescence . Philadelphia, WB Saunders Co, 1980, pp 165-172. 3. Peltola H, Karanko V, Kurki T, et al: Rapid effect on endemic measles, mumps and rubella of nationwide vaccination programme in Finland . Lancet 1986;1:137-139.Crossref 4. Buynak EB, Weibel RE, Whitman JE, et al: Combined live measles, mumps, and rubella virus vaccines . JAMA 1969;207:2259-2262.Crossref 5. Weibel RE, Carlson AJ Jr, Villarejos VM, et al: Clinical and laboratory studies of combined live measles, mumps, and rubella vaccinees using the RA 27/3 rubella virus (40979) . Proc Soc Exp Biol Med 1980;165:323-326.Crossref 6. Immunization Practices Advisory Committee: Measles prevention . MMWR 1982;31:217-231. 7. Kamin PB, Fein BT, Britton HA: Use of live, attenuated measles virus vaccine in children allergic to egg protein . JAMA 1965;195:143-144. 8. Aukrust JB, Almeland TL, Rafsum D, et al: Severe hypersensitivity or intolerance reactions to measles vaccine in six children: Clinical and immunological studies . Allergy 1980;35:581-587.Crossref 9. Nieburg PI, Preblud SR, Halsey BA, et al: Measles vaccine in egg-allergic children . Pediatrics 1980;65:365-366. 10. Klein JD (ed): Report of the Committee on Infectious Diseases . Evanston, Ill, American Academy of Pediatrics, 1982. 11. Hermann JJ, Radin R, Schneiderman R: Allergic reactions to measles (rubeola) vaccine in patients hypersensitive to egg protein . J Pediatr 1983;102:196-199.Crossref 12. Rachelefsky GS, Jacobs AH: Atopic dermatitis , in Bierman CW, Pearlman DS (eds): Allergic Diseases of Infancy, Childhood and Adolescence . Philadelphia, WB Saunders Co, 1980, pp 410-430. 13. Savilahti E: Cow's milk allergy . Allergy 1981;36:73-88.Crossref 14. Gavani UD, Hyde JS, Moore BS: Hypersensitivity to milk and egg white: Skin tests, RAST results and clinical intolerance . Ann Allergy 1978;40:314-318. 15. Norman PS: In vivo methods of study of allergy , in Middleton E Jr, Reed CE, Ellis EF (eds): Allergy, Principles and Practice . St Louis, CV Mosby Co, 1978, pp 256-264. 16. Bierman CW, Shapiro GG, Pierson WE, et al: Safety of influenza vaccination in allergic children . J Infect Dis 1977;136( (suppl) ):652-655.Crossref 17. Miller JR, Orgel HA, Meltzer EO: The safety of egg-containing vaccines for egg allergic patients . J Allergy Clin Immunol 1983;7: 568-573.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Oct 1, 1987

References