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Rubella Vaccine Evaluation in a Public School System

Rubella Vaccine Evaluation in a Public School System Abstract CURRENTLY there are several candidate rubella vaccines being evaluated in various populations.1,2 The vaccines are live, attenuated, high-passage viral preparations, differing in the cell type used for propagation, but apparently quite similar in their behavior in humans. The Clinical Virology Section (CVS) at the University of Cincinnati Medical Center has been involved in a series of closed adult population studies which evaluated the effects of several of the vaccines (G.M.S., unpublished data). Our findings, which confirmed the reports of other investigators,1-5 showed that the vaccines were antigenic, safe, caused few symptoms or signs, and were incapable of spread to contacts. These results indicated that vaccine evaluation could safely proceed to larger and open populations. A number of open-population studies have been and are being conducted.5-7 Preliminary reports from these studies reinforced the earlier closed-population results and indicated that the vaccines were effective and safe for evaluation in References 1. Perkins, F.T.: A Review of Recent Studies With Rubella Vaccines , Public Health 81:284-288 ( (Sept) ) 1967.Crossref 2. Buynak, E.B., et al: Live Attenuated Rubella Virus Vaccines Prepared in Duck Embryo Cell Culture: I. Development and Clinical Testing , JAMA 204:195-200 ( (April 15) ) 1968.Crossref 3. Meyer, H.M., Jr., et al: Clinical Studies With Experimental Live Rubella Virus Vaccine (Strain HPV-77): Evaluation of Vaccine-Induced Immunity , Amer J Dis Child 115:648-654 ( (June) ) 1968.Crossref 4. Du Pan, R.M., et al: Clinical Trials With a Live Attenuated Rubella Virus Vaccine: Cendehill 51 Strain , Amer J Dis Child 115:658-662 ( (June) ) 1968.Crossref 5. McCollum, R.W.: " Vaccination of Children With HPV-77 Vaccine Prepared in Duck Embryo (DE) Tissue ," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969. 6. Cherry, J.D.; Bobinski, J.E.; and Comerce, G.D.: " Clinical Trials With Attenuated Rubella Virus Vaccine (Cendehill Strain) ," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969. 7. Buser, F.; Nicolas, A.; and Plotkin, S.A.: " Vaccinations Against Rubella With an Attenuated Rubella Virus Strain Adapted to a Human Diploid Cell Strain ," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969. 8. Peetermans, J., and Huygelen, C.: Attenuation of Rubella Virus by Serial Passage in Primary Rabbit Kidney Cell Cultures: I. Growth Characteristics in Vitro and Production of Experimental Vaccines at Different Passage Levels , Arch Ges Virusforsch 21:133-143, 1967.Crossref 9. Stewart, G.L., et al: Rubella-Virus Hemagglutination-Inhibition Test , New Eng J Med 276: 554-557 ( (March 9) ) 1967.Crossref 10. Lennette, E.H., and Schmidt, N.J. (eds.): Diagnostic Procedures for Viral and Rickettsial Diseases , ed 3, New York: American Public Health Assoc., 1964. 11. Sencer, D.J.; Witte, J.J.; and Karchmer, A.W.: " The Epidemiology of Rubella in the United States ," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969. 12. Horstmann, D.M.: " Comparison of HPV-77 D-5 and Cendehill Strain Vaccines in Adult Women ," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969. 13. Cooper, L.Z., et al: " Arthritis Following Immunization With Rubella Vaccines ," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969. 14. Stokes, J., et al: " Vaccination of Adult Females With HPV-77 Rubella Vaccine ," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Rubella Vaccine Evaluation in a Public School System

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1969.02100040205008
Publisher site
See Article on Publisher Site

Abstract

Abstract CURRENTLY there are several candidate rubella vaccines being evaluated in various populations.1,2 The vaccines are live, attenuated, high-passage viral preparations, differing in the cell type used for propagation, but apparently quite similar in their behavior in humans. The Clinical Virology Section (CVS) at the University of Cincinnati Medical Center has been involved in a series of closed adult population studies which evaluated the effects of several of the vaccines (G.M.S., unpublished data). Our findings, which confirmed the reports of other investigators,1-5 showed that the vaccines were antigenic, safe, caused few symptoms or signs, and were incapable of spread to contacts. These results indicated that vaccine evaluation could safely proceed to larger and open populations. A number of open-population studies have been and are being conducted.5-7 Preliminary reports from these studies reinforced the earlier closed-population results and indicated that the vaccines were effective and safe for evaluation in References 1. Perkins, F.T.: A Review of Recent Studies With Rubella Vaccines , Public Health 81:284-288 ( (Sept) ) 1967.Crossref 2. Buynak, E.B., et al: Live Attenuated Rubella Virus Vaccines Prepared in Duck Embryo Cell Culture: I. Development and Clinical Testing , JAMA 204:195-200 ( (April 15) ) 1968.Crossref 3. Meyer, H.M., Jr., et al: Clinical Studies With Experimental Live Rubella Virus Vaccine (Strain HPV-77): Evaluation of Vaccine-Induced Immunity , Amer J Dis Child 115:648-654 ( (June) ) 1968.Crossref 4. Du Pan, R.M., et al: Clinical Trials With a Live Attenuated Rubella Virus Vaccine: Cendehill 51 Strain , Amer J Dis Child 115:658-662 ( (June) ) 1968.Crossref 5. McCollum, R.W.: " Vaccination of Children With HPV-77 Vaccine Prepared in Duck Embryo (DE) Tissue ," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969. 6. Cherry, J.D.; Bobinski, J.E.; and Comerce, G.D.: " Clinical Trials With Attenuated Rubella Virus Vaccine (Cendehill Strain) ," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969. 7. Buser, F.; Nicolas, A.; and Plotkin, S.A.: " Vaccinations Against Rubella With an Attenuated Rubella Virus Strain Adapted to a Human Diploid Cell Strain ," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969. 8. Peetermans, J., and Huygelen, C.: Attenuation of Rubella Virus by Serial Passage in Primary Rabbit Kidney Cell Cultures: I. Growth Characteristics in Vitro and Production of Experimental Vaccines at Different Passage Levels , Arch Ges Virusforsch 21:133-143, 1967.Crossref 9. Stewart, G.L., et al: Rubella-Virus Hemagglutination-Inhibition Test , New Eng J Med 276: 554-557 ( (March 9) ) 1967.Crossref 10. Lennette, E.H., and Schmidt, N.J. (eds.): Diagnostic Procedures for Viral and Rickettsial Diseases , ed 3, New York: American Public Health Assoc., 1964. 11. Sencer, D.J.; Witte, J.J.; and Karchmer, A.W.: " The Epidemiology of Rubella in the United States ," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969. 12. Horstmann, D.M.: " Comparison of HPV-77 D-5 and Cendehill Strain Vaccines in Adult Women ," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969. 13. Cooper, L.Z., et al: " Arthritis Following Immunization With Rubella Vaccines ," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969. 14. Stokes, J., et al: " Vaccination of Adult Females With HPV-77 Rubella Vaccine ," in Proceedings of the 23rd Symposium on Microbiological Standardization: Rubella Vaccines , London, (November) 1968, Basel, Switzerland: S. Karger, 1969.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Aug 1, 1969

References