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Abstract ALTHOUGH the virus is generally accepted as the causative organism of the common cold, much obscurity exists concerning the role of contributory factors, such as exposure to cold, fatigue and debility. These elements of one's environment have been much discussed in the literature, so that only a brief résumé will be necessary here. The purpose of this paper, however, is to suggest another factor, allergy, which will be discussed in relation to factors already known. THE CASE OF EXPOSURE TO COLD Since time immemorial, chilling has been considered a factor in the pathogenesis of the common cold. The Germans express this thought in the term Erkältung. Certain investigators1 had noted changes in the nasal mucosa of persons exposed to heat and cold, but none of these investigators produced laboratory evidence of these changes until Mudd and his associates2 published their work. They then showed that cutaneous chilling causes References 1. Hill, L., and Muecke, F. F.: Colds in the Head and the Influence of Warm Confined Atmospheres on the Mucous Membranes of the Nose and Throat , Lancet 1:1291, 1943. 2. Schade, H.: Untersuchungen in der Erkältungsfrage , München. med. Wchnschr. 66:1021, 1919 3. 67:449, 1920. 4. Mudd, S.; Grant, S. B., and Goldman, A.: Reactions of the Nasal Cavity and Postnasal Space to Chilling of the Body Surface: I. Vasomotor Reactions , J. Exper. Med. 34:11, 1921.Crossref 5. Ralston, H. J., and Kerr, W. J.: Vascular Responses of the Nasal Mucosa to Thermal Stimuli, with Some Observations on Skin Temperature , Am. J. Physiol. 144:305, 1945. 6. Spiesman, I. G.: An Experimental and Clinical Study of the Common Cold , Ann. Otol., Rhin. & Laryng. 50:204, 1941. 7. Spiesman, I. G., and Arnold, L.: Host Susceptibility to Common Colds , Am. J. Digest. Dis. 4:438, 1937. 8. Ralston and Kerr.3 9. Kruse, W.: Die Erreger von Husten und Schnupfen , München. med. Wchnschr. 61:1547, 1914. 10. Powell, H. M., and Clowes, G. H. 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F.: A Study of the Acute Infections of the Throat and Respiratory System , J. A. M. A. 82:540 ( (Feb. 16) ) 1924Crossref 32. footnote 15. 33. Layton, T. B.: The Common Cold , Practitioner 154:65, 1945. 34. Coca, A. F.: Familial Nonreaginic Food Allergy as a Predisposing Cause of Common Cold , J. Lab. & Clin. Med. 26:757, 1941. 35. Hoelzel, F.: Nutritional Edema and Its Relation to the Incidence of Common Colds , Proc. Soc. Exper. Biol. & Med. 25:454, 1928. 36. McQuarrie, I.: Protein Metabolism of Children on Diets Extremely Low in Carbohydrates , J. Nutrition 2:31, 1929. 37. Higgins, H. L.: Some Physiological and Clinical Effects of High Fat Feeding , New England J. Med. 203:145, 1930. 38. Brown, W. B.; Graham, I.; Niedringhaus, A., and Locke, A.: Non-Specific Factors in Resistance: VI. Incidence of Common Cold in Persons With and Without Accessory Symptomatology of Nonreaginic Food-Allergy , J. Immunol. 46:101, 1943. 39. Brown, W. B., and Locke, A. P.: Fitness, Food Allergy and Predisposition to Common Cold , J. Missouri M. A. 40:99, 1943. 40. Duke, W. W.: Urticaria Caused Specifically by the Action of Physical Agents (Light, Cold, Heat, Freezing, Burns, Mechanical Irritation and Physical and Mental Exertion) , J. A. M. A. 83:3 ( (July 5) ) 1924 41. Physical Allergy: Preliminary Report , J. A. M. A. 84:736 ( (March 7) ) 1925. 42. Swineford, O., Jr.: Physical Allergy: Its Role as Manifested in the Routine Study of Three Hundred and Twenty-Five Consecutive Allergic Cases , J. Allergy 6:175, 1935. 43. Vaughan, W. T.: Practice of Allergy , St. Louis, C. V. Mosby Company, 1939. 44. Bray, G. W.: A Case of Physical Allergy , Brit. J. Child. Dis. 32:45, 1935. 45. Duran-Reynals, F.: Tissue Permeability and the Spreading Factor in Infection: Contribution to Host; Parasite Problem , Bact. Rev. 6:197, 1942. 46. Fox, N.; Harned, J. W., and Peluse, S.: Borderline Allergy: Its Relation to Hyperplastic Disease of the Respiratory Tract , Arch. Otolaryng. 31:502 ( (March) ) 1940. 47. Fox. N., and Harned, J. W.: Treatment of Asthmatic Patients in Otolaryngologic Practice , Arch. Otolaryng. 25:393 ( (April) ) 1937.Crossref 48. Troescher-Elam, E.; Ancona, G., and Kerr, W. J.: Histamine-Like Substance Present in Nasal Secretions of Common Cold and Allergic Rhinitis , Am. J. Physiol. 144:711, 1945.
Archives of Otolaryngology – American Medical Association
Published: Jun 1, 1949
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