EPIDEMIOLOGY SECTION EDITOR: LESLIE HYMAN, PhD Risk Alleles in CFH and ARMS2 and the Long-term Natural History of Age-Related Macular Degeneration The Beaver Dam Eye Study Ronald Klein, MD, MPH; Chelsea E. Myers, MStat; Stacy M. Meuer, BS; Ronald E. Gangnon, PhD; Theru A. Sivakumaran, PhD; Sudha K. Iyengar, PhD; Kristine E. Lee, MS; Barbara E. K. Klein, MD, MPH Objective: To describe the relationships of risk alleles in for AMD, respectively. The 5-year incidences of early and complement factor H (CFH, rs1061170) and age-related late AMD were 9.1% and 1.6%, respectively, and in- maculopathy susceptibility 2 (ARMS2, rs10490924) to the creased with age but did not differ significantly by sex. Using incidence and progression of age-related macular degen- the multistate model, of persons aged 45 years with no AMD eration (AMD) during a 20-year period. in the low, intermediate, and high AMD genetic risk groups, 33.0%, 39.9%, and 46.5%, respectively, were estimated to Methods: There were 4282 persons aged 43 to 86 years develop early AMD, and 1.4%, 5.2%, and 15.3% were es- at the baseline examination in 1988-1990 enrolled in a timated to develop late AMD by age 80 years. population-based cohort study who participated in at
JAMA Ophthalmology – American Medical Association
Published: Mar 1, 2013
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