Abstract A 14-year-old girl with a vitamin D-poor diet and receiving phenobarbital for epilepsy developed florid rickets. After being cured of this, and while on a maintenance dose of vitamin D, the addition of diphenylhydantoin sodium was accompanied by a recurrence of the rickets, which was corrected by raising the dosage of vitamin D from 600 to 1,200 international units per day. References 1. Kruse R: Osteopathien bei antiepileptischer Langzeittherapie . Monatsschr Kinderheilkd 116:378-383, 1968. 2. Richens A, Rowe DJF: Disturbance of calcium metabolism by anticonvulsant therapy . Br Med J 4:73-77, 1970.Crossref 3. Dent CE, et al: Osteomalacia with long term anticonvulsant therapy . Br Med J 4:69-72, 1970.Crossref 4. Borgstedt AD, et al: Long-term administration of antiepileptic drugs and the development of rickets . J Pediatr 81:9-15, 1972.Crossref 5. Toman JEP, cited in Goodman LS, Gillman A (eds): Pharmacological Basis of Therapeutics . New York, Macmillan Co Publishers, 1965, p 215. 6. DeLuca HF: Vitamin D: A new look at an old vitamin . Nutr Rev 29:179-181, 1971.Crossref 7. DeLuca HF: Parathyroid hormone as a trophic hormone for 1,25-dihydroxyvitamin D3, the metabolically active form of vitamin D . N Engl J Med 287:250-251, 1972.Crossref 8. Avioli LV: Absorption and metabolism of vitamin D2 . Am J Clin Nutr 22:437-441, 1969. 9. Stern L, et al: Effect of phenobarbitone on hyper bilirubinemia and glucuronide formation in newborns . Am J Dis Child 120:26-31, 1970. 10. DeLuca HF: Current concepts in vitamin D metabolism . N Engl J Med 281:1103-1106, 1969b.Crossref
American Journal of Diseases of Children – American Medical Association
Published: Jun 1, 1973
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