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/lp/american-medical-association/riboflavin-self-report-and-serum-norethindrone-comparison-of-their-use-bvwZ00p0F0
- Publisher
- American Medical Association
- Copyright
- Copyright © 1984 American Medical Association. All Rights Reserved.
- ISSN
- 0002-922X
- DOI
- 10.1001/archpedi.1984.02140390058018
- Publisher site
- See Article on Publisher Site
Abstract
Abstract • The purpose of this study was to test the reliability of using the tablet marker, riboflavin, as an indicator of adolescent compliance with oral contraceptives, as compared with self-reports and more costly quantitative determinations of serum norethindrone levels. In a pilot study, a total of 31 urine samples were obtained from 11 subjects, aged 14 to 18 years. A follow-up study was conducted on 26 girls, aged 14 to 19 years, who were randomly selected from an ongoing study of oral contraceptive compliance. Subjects were given an oral contraceptive (Ortho-Novum 1/35), combined with 28 mg of riboflavin. In both studies, urinary fluorescence tests for riboflavin and self-reports were found to be significantly associated. In the follow-up study, both self-reports and urinary fluorescence tests were significantly associated with serum norethindrone levels. When the urinary fluorescence test agreed with self-report, compliance or noncompliance was confirmed by serum norethindrone levels in 90% of the cases. The findings suggest that riboflavin, combined with self-report, can be used as an accurate and cost-effective indicator of adolescent compliance with oral contraceptives. (AJDC 1984;138:70-73) References 1. Zelnik M, Kanter JF: Sexual activity, contraceptive use, and pregnancy among metropolitan-area teenagers: 1971-1979 . Fam Plann Perspect 1980;12:230-237.Crossref 2. Litt IF, Cuskey WR, Rudd S: Identifying adolescents at risk for non-compliance with contraceptive therapy . J Pediatr 1980;96:742-745.Crossref 3. Gordis L: Conceptual and methodologic problems in measuring patient compliance , in Haynes RB, Taylor DW, Sackett DL (eds): Compliance in Health Care . Baltimore, The Johns Hopkins University Press, 1979, pp 23-48. 4. Litt IF, Cuskey WR: Compliance with medical regimens during adolescence . 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Joyce CR: Patient and the sensitivity of clinical trials . J Chronic Dis 1962;15:1025-1036.Crossref 13. Jones IH: Riboflavin as an indicator of drug taking behavior . Med J Aust 1967;1:202-204. 14. Jay S, Litt IF: Riboflavin as an indicator of oral contraceptive compliance . J Adolesc Health Care 1980;1:178.Crossref 15. Parker CR, Ellegood JO, Mahesh VB: Methods for multiple steroid radioimmunoassay . J Steroid Biochem 1975;6:1-8.Crossref 16. Mills TM, Lin TJ, Braselton WE, et al: Metabolism of oral contraceptive drugs: The formulation and disappearance of metabolites of norethindrone and mestranol after intravenous and oral administration . Am J Obstet Gynecol 1976;126:987-996. 17. Mahesh VB, Mills TM, Lin TJ, et al: Metabolism, metabolic clearance rate of blood metabolites, and blood half-life of norethindrone and mestranol , in Garratini S, Berendes HW (eds): Pharmacology of Steroid Contraceptive Drugs . New York, Raven Press, 1977, pp 117-130. 18. 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Jusko WJ, Levy G: Absorption, protein binding, and elimination of riboflavin , in Rivlin RS (ed): Riboflavin . New York, Plenum Press, 1975, pp 99-152. 26. Jusko WJ, Levy G: Absorption, metabolism, and excretion of riboflavin 51-phosphate in man . J Pharm Sci 1967;56:58-61.Crossref 27. Jusko WJ, Khanna N, Levy G, et al: Riboflavin absorption and excretion in the neonate . Pediatrics 1970;45:945-949. 28. Jay S, DuRant RH, Shoffitt T, et al: The effect of peer counselors on adolescent compliance with oral contraceptives. Pediatrics, in press. 29. DuRant RH, Jay S, Linder CW, et al: The influence of psychosocial factors on adolescent compliance with oral contraceptives. J Adolesc Health Care, in press.
Journal
American Journal of Diseases of Children – American Medical Association
Published: Jan 1, 1984