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Rhinomucormycosis Resulting in Fatal Cerebral Mucormycosis

Rhinomucormycosis Resulting in Fatal Cerebral Mucormycosis Abstract The early identification of the primitive class of fungi, the Phycomycetes, in the biopsy and culture of the nasal and paranasal lesions of two diabetic patients led to the control of the spread of the fungi into the brain, where fatal cerebral mucormycosis might have resulted (Harris1; Baker, Andrews and Izlar2). The fungi of the genus Rhizopus of the order Mucorales were identified in both patients. Fifteen of the seventeen recorded cases, including the present case, died as a result of the spread of the fungi into the brain (Table). Earlier recognition through biopsy or culture of the nasal or paranasal lesions may have averted cerebral spread and death. All of the reported cases had an underlying, debilitating disease. Uncontrolled or poorly controlled diabetes mellitus1-7 provided a favorable medium of growth of the fungi in 11 of the 17 recorded cases, including the present case. The underlying References 1. Harris, J. S.: Mucormycosis: Report of a Case , Pediatrics 16:857-867 ( (Dec.) ) 1955. 2. Baker, R. D.; Andrews, J. P., and Izlar, H. L., Jr.: Mucormycotic Sinusitis, cited by Baker.13 3. Gregory, J. E.; Golden, A., and Haymaker, W.: Mucormycosis of the Central Nervous System: Report of 3 Cases , Bull. Johns Hopkins Hosp. 73:405-419 ( (Dec.) ) 1943. 4. LeCompte, P. M., and Meissner, W. A.: Mucormycosis of the Central Nervous System Associated with Hemochromatosis , Am. J. Path. 23:673-677 ( (July) ) 1947. 5. Wolf, A., and Cowen, D.: Mucormycosis of the Central Nervous System , abstracted, J. Neuropath. & Exper. Neurol. 8:107 ( (Jan.) ) 1949. 6. Stratemeier, W. P.: Mucormycosis of the Central Nervous System: Report of a Case , Arch. Neurol. & Psychiat. 63:179-180 ( (Jan.) ) 1950. 7. Bauer, H.; Ajello, L.; Adams, E., and Useda Hernandez, D.: Cerebral Mucormycosis: Pathogenesis of the Disease; Description of the Fungus, Rhizopus Oryzae, Isolated from a Fatal Case , Am. J. Med. 18:822-831 ( (May) ) 1955. 8. Kurrein, F.: Cerebral Mucormycosis , J. Clin. Path. 7:141-144 ( (May) ) 1954. 9. Gunson, H. H., and Bowden, D. H.: Cerebral Mucormycosis: Report of a Case , A. M. A. Arch. Path. 60:440-443 ( (Oct.) ) 1955. 10. Martin, F. P.; Lukeman, J. M.; Ranson, R. F., and Gippert, L. J.: Mucormycosis of the Central Nervous System Associated with Thrombosis of the Internal Carotid Artery , J. Pediat. 44:437-442 ( (April) ) 1954. 11. Foushee, S., and Beck, W. C.: Mucormycosis of the Central Nervous System: Case Report , North Carolina M. J. 17:26-31 ( (Jan.) ) 1956. 12. Mayfield, G. R., and Condie, F.: Paradoxical Mucorthrombosis in Thrombocytopenic Purpura , A. M. A. Arch. Path. 63:260-264 ( (March) ) 1957. 13. Baker, R. D.: Mucormycosis—a New Disease? J. A. M. A. 163:805-808, ( (March 9) ) 1957. 14. Bauer, H.; Flanagan, J. F., and Sheldon, W. H.: The Effects of Metabolic Alteration on Experimental Rhizopus Oryzae (Mucormycosis) Infection , Yale J. Biol. & Med. 29:23-32 ( (Sept.) ) 1956. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Otolaryngology American Medical Association

Rhinomucormycosis Resulting in Fatal Cerebral Mucormycosis

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Publisher
American Medical Association
Copyright
Copyright © 1958 American Medical Association. All Rights Reserved.
ISSN
0096-6894
DOI
10.1001/archotol.1958.00730010633022
Publisher site
See Article on Publisher Site

Abstract

Abstract The early identification of the primitive class of fungi, the Phycomycetes, in the biopsy and culture of the nasal and paranasal lesions of two diabetic patients led to the control of the spread of the fungi into the brain, where fatal cerebral mucormycosis might have resulted (Harris1; Baker, Andrews and Izlar2). The fungi of the genus Rhizopus of the order Mucorales were identified in both patients. Fifteen of the seventeen recorded cases, including the present case, died as a result of the spread of the fungi into the brain (Table). Earlier recognition through biopsy or culture of the nasal or paranasal lesions may have averted cerebral spread and death. All of the reported cases had an underlying, debilitating disease. Uncontrolled or poorly controlled diabetes mellitus1-7 provided a favorable medium of growth of the fungi in 11 of the 17 recorded cases, including the present case. The underlying References 1. Harris, J. S.: Mucormycosis: Report of a Case , Pediatrics 16:857-867 ( (Dec.) ) 1955. 2. Baker, R. D.; Andrews, J. P., and Izlar, H. L., Jr.: Mucormycotic Sinusitis, cited by Baker.13 3. Gregory, J. E.; Golden, A., and Haymaker, W.: Mucormycosis of the Central Nervous System: Report of 3 Cases , Bull. Johns Hopkins Hosp. 73:405-419 ( (Dec.) ) 1943. 4. LeCompte, P. M., and Meissner, W. A.: Mucormycosis of the Central Nervous System Associated with Hemochromatosis , Am. J. Path. 23:673-677 ( (July) ) 1947. 5. Wolf, A., and Cowen, D.: Mucormycosis of the Central Nervous System , abstracted, J. Neuropath. & Exper. Neurol. 8:107 ( (Jan.) ) 1949. 6. Stratemeier, W. P.: Mucormycosis of the Central Nervous System: Report of a Case , Arch. Neurol. & Psychiat. 63:179-180 ( (Jan.) ) 1950. 7. Bauer, H.; Ajello, L.; Adams, E., and Useda Hernandez, D.: Cerebral Mucormycosis: Pathogenesis of the Disease; Description of the Fungus, Rhizopus Oryzae, Isolated from a Fatal Case , Am. J. Med. 18:822-831 ( (May) ) 1955. 8. Kurrein, F.: Cerebral Mucormycosis , J. Clin. Path. 7:141-144 ( (May) ) 1954. 9. Gunson, H. H., and Bowden, D. H.: Cerebral Mucormycosis: Report of a Case , A. M. A. Arch. Path. 60:440-443 ( (Oct.) ) 1955. 10. Martin, F. P.; Lukeman, J. M.; Ranson, R. F., and Gippert, L. J.: Mucormycosis of the Central Nervous System Associated with Thrombosis of the Internal Carotid Artery , J. Pediat. 44:437-442 ( (April) ) 1954. 11. Foushee, S., and Beck, W. C.: Mucormycosis of the Central Nervous System: Case Report , North Carolina M. J. 17:26-31 ( (Jan.) ) 1956. 12. Mayfield, G. R., and Condie, F.: Paradoxical Mucorthrombosis in Thrombocytopenic Purpura , A. M. A. Arch. Path. 63:260-264 ( (March) ) 1957. 13. Baker, R. D.: Mucormycosis—a New Disease? J. A. M. A. 163:805-808, ( (March 9) ) 1957. 14. Bauer, H.; Flanagan, J. F., and Sheldon, W. H.: The Effects of Metabolic Alteration on Experimental Rhizopus Oryzae (Mucormycosis) Infection , Yale J. Biol. & Med. 29:23-32 ( (Sept.) ) 1956.

Journal

A.M.A. Archives of OtolaryngologyAmerican Medical Association

Published: May 1, 1958

References