Abstract RHEUMATOID spondylitis has been known by many names in the past, among them rhyzomelic spondylitis, Marie-Strümpell's disease, von Bechterew's syndrome, ankylosing spondylitis, spondylitis deformans, and atrophic spondylitis.3 This is generally considered to be a disease of young adult males, the age of onset in the vast majority of cases occurring between 15 and 40 years of age.3 The disease occurs predominantly in males, with the sex ratio usually reported as 10:1,* though varying in extremes from 4:1 to 20: 1.† A review of the literature reveals a striking paucity of reports of the development of this disease in prepubertal girls. Tyson and co-workers,16 in a 20-year study of the rheumatoid spondylitis patients seen at the Presbyterian and New York Orthopedic Hospitals, stated that the youngest age of onset seen in girls was 14 years. No statement was made regarding the correlation with puberty. Polley and Slocumb‡ References 1. Bauer, W.: The Diagnosis of the Various Arthritides , New England J. Med. 221:524, 1939.Crossref 2. Boland, E. W.: Spondylitis, in Comroe's Arthritis and Allied Conditions , Ed. 5, Philadelphia, Lea & Febiger, 1925, p. 574. 3. Hilton, G.: Some Observations on the X-ray Treatment of Ankylosing Spondylitis , Proc. Roy. Soc. Med. 36:608, 1943. 4. Johnson, N. J., and Dodd, K.: Juvenile Rheumatoid Arthritis , M. Clin. North America 39:459, 1955. 5. Lucchesi, M., and Lucchesi, O.: Rheumatoid Spondylitis: A Paediatric Problem , Ann. Rheumat. Dis. 9:372, 1950.Crossref 6. Michael, M., Jr.: Disorders of Joints , in Harrison, T. R.: Principles of Internal Medicine , New York, Blakiston Company, 1951, p. 474. 7. Milne, J.: Serum Protein Fractions: A Comparison of Sodium Sulfate Precipitation and Electrophoresis , J. Biol. Chem. 169:595, 1947. 8. Pickard, N. S.: Rheumatoid Arthritis in Children: A Clinical Study , Arch. Int. Med. 80:771, 1947.Crossref 9. Polley, H. F., and Slocumb, C. H.: Rheumatoid Spondylitis: A Study of 1,035 Cases , Ann. Int. Med. 26:240 10. Correction 26:304, 1947. 11. Pugh, D. G.: Rheumatoid Spondylitis , Nelson's Diagnostic Roentgenology , Baltimore, Williams & Wilkins Company, 1936, Vol. 2, p. 543. 12. Rose, H. M.; Ragan, C.; Pearce, E., and Lipman, M. O.: Differential Agglutination of Normal and Sensitized Sheep Erythrocytes by Sera of Patients with Rheumatoid Arthritis , Proc. Soc. Exper. Biol. & Med. 68:1, 1948. 13. Shetlar, M. R.; Foster, J. V., and Everett, M. R.: Determination of Serum Polysaccharides by the Tryptophane Reaction , Proc. Soc. Exper. Biol. & Med. 67:125, 1948. 14. Shetlar, M. R.; Payne, R. W.; Bullock, J. A.; Patrick, D. R.; Hellbaum, A. A., and Ishmael, W. K.: Comparative Studies of Serum Polysaccharides in Rheumatoid Arthritis and Degenerative Joint Disease , J. Clin. Invest. 32:1208, 1953. 15. Steinbrocker, O.: Arthritis in Modern Practice , Philadelphia, W. B. Saunders Company, 1942, p. 95. 16. Turney, H. F.: Ankylosing Spondylitis: President's Address , Proc. Roy. Soc. Med. 45:57, 1952. 17. Tyson, T. L.; Thompson, W. A. L., and Ragan, C.: Marie-Strümpell Spondylitis in Women , Ann. Rheumat. Dis. 12:40, 1953. 18. Ziff, M.; Brown, P.; Baden, J., and McEwen, C.: A Hemagglutination Test for Rheumatoid Arthritis with Enhanced Sensitivity Using the Euglobulin Fraction , Bull. Rheumat. Dis. 5:75, 1954.
A.M.A. Journal of Diseases of Children – American Medical Association
Published: Feb 1, 1956
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