Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Reye Syndrome Without Initial Hepatic Involvement

Reye Syndrome Without Initial Hepatic Involvement Abstract • We report Reye syndrome in an 11-year-old boy whose first symptoms were generalized convulsions and coma without clinical or laboratory evidence of liver disease. Serum glutamic oxaloacetic transaminase and lactate dehydrogenase (LDH) values increased strikingly on the third day after the onset of coma. These enzymatic changes were associated with prolongation of prothrombin time. A rise in blood ammonia concentrations began on the fourth day of coma. The diagnosis of Reye syndrome was confirmed by a liver biopsy and at autopsy. This case demonstrates that encephalopathy in Reye syndrome can develop prior to detectable hepatic involvement, and suggests that factors unrelated to generalized liver damage may occasionally play a role in the pathogenesis of this obscure disorder. (Am J Dis Child 131:295-296, 1977) References 1. Reye RDK, Morgan G, Baral J: Encephalopathy and fatty degeneration of the viscera: A disease entity in childhood . Lancet 2:749-752, 1963.Crossref 2. Huttenlocher PR: Reye's syndrome: Relation of outcome to therapy . J Pediatr 80:845-850, 1972.Crossref 3. Huttenlocher PR, Schwartz AD, Klatskin G: Reye's syndrome: Ammonia intoxication as a possible factor in the encephalopathy . Pediatrics 43:443-454, 1969. 4. Trauner DA, David RB, Madge G, et al: Reye's syndrome and free fatty acid-induced coma , abstracted. Pediatr Res 6:329, 1972. 5. Tanaka K, Isselbacher KJ, Shih V: Isovaleric and α-methyl-butyric acidemias induced by hypoglycin A: Mechanism of Jamaica vomiting sickness . Science 175:69-71, 1972.Crossref 6. Crocker JFS, Rozee KR, Ozere RL, et al: Insecticide and viral interaction as a cause of fatty visceral changes and encephalopathy in the mouse . Lancet 2:22-24, 1974.Crossref 7. Samaha FJ, Blair E, Berardinelli JL: Reye's syndrome treatment with peritoneal dialysis . Pediatrics 53:336-340, 1974. 8. Nadler H: Therapeutic delirium in Reye's syndrome . Pediatrics 54:265-266, 1974. 9. Lovejoy FH Jr, Smith AL, Bresnan MJ, et al: Clinical staging in Reye syndrome . Am J Dis Child 128:36-41, 1974. 10. Thaler MM: Metabolic mechanisms in Reye syndrome: End of a mystery? Am J Dis Child 130:241-243, 1976.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Reye Syndrome Without Initial Hepatic Involvement

Loading next page...
 
/lp/american-medical-association/reye-syndrome-without-initial-hepatic-involvement-OkGEUetAE9

References (11)

Publisher
American Medical Association
Copyright
Copyright © 1977 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1977.02120160049008
Publisher site
See Article on Publisher Site

Abstract

Abstract • We report Reye syndrome in an 11-year-old boy whose first symptoms were generalized convulsions and coma without clinical or laboratory evidence of liver disease. Serum glutamic oxaloacetic transaminase and lactate dehydrogenase (LDH) values increased strikingly on the third day after the onset of coma. These enzymatic changes were associated with prolongation of prothrombin time. A rise in blood ammonia concentrations began on the fourth day of coma. The diagnosis of Reye syndrome was confirmed by a liver biopsy and at autopsy. This case demonstrates that encephalopathy in Reye syndrome can develop prior to detectable hepatic involvement, and suggests that factors unrelated to generalized liver damage may occasionally play a role in the pathogenesis of this obscure disorder. (Am J Dis Child 131:295-296, 1977) References 1. Reye RDK, Morgan G, Baral J: Encephalopathy and fatty degeneration of the viscera: A disease entity in childhood . Lancet 2:749-752, 1963.Crossref 2. Huttenlocher PR: Reye's syndrome: Relation of outcome to therapy . J Pediatr 80:845-850, 1972.Crossref 3. Huttenlocher PR, Schwartz AD, Klatskin G: Reye's syndrome: Ammonia intoxication as a possible factor in the encephalopathy . Pediatrics 43:443-454, 1969. 4. Trauner DA, David RB, Madge G, et al: Reye's syndrome and free fatty acid-induced coma , abstracted. Pediatr Res 6:329, 1972. 5. Tanaka K, Isselbacher KJ, Shih V: Isovaleric and α-methyl-butyric acidemias induced by hypoglycin A: Mechanism of Jamaica vomiting sickness . Science 175:69-71, 1972.Crossref 6. Crocker JFS, Rozee KR, Ozere RL, et al: Insecticide and viral interaction as a cause of fatty visceral changes and encephalopathy in the mouse . Lancet 2:22-24, 1974.Crossref 7. Samaha FJ, Blair E, Berardinelli JL: Reye's syndrome treatment with peritoneal dialysis . Pediatrics 53:336-340, 1974. 8. Nadler H: Therapeutic delirium in Reye's syndrome . Pediatrics 54:265-266, 1974. 9. Lovejoy FH Jr, Smith AL, Bresnan MJ, et al: Clinical staging in Reye syndrome . Am J Dis Child 128:36-41, 1974. 10. Thaler MM: Metabolic mechanisms in Reye syndrome: End of a mystery? Am J Dis Child 130:241-243, 1976.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Mar 1, 1977

There are no references for this article.