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Reye Syndrome and Aspirin Therapy

Reye Syndrome and Aspirin Therapy Abstract Sir.—A significant number of children require long-term aspirin therapy for collagen vascular disorders, rheumatic fever, and other inflammatory diseases. Several cases of Reye syndrome (RS) have recently been documented in these children, who may actually be at an increased risk to develop the syndrome.1 Although reports indicate a decline in the incidence of acute rheumatic fever (ARF),2 a recent dramatic resurgence of ARF has occurred in Utah. This resurgence is reflected in the increased number of ARF admitted to Primary Children's Hospital, Salt Lake City, in 1985: Average No. Period of Cases 1960-1964 24.6 1965-1969 18.0 1970-1974 14.2 1975-1979 5.0 1980-1984 7.6 1985 50 (Actual No.) We describe herein a child who developed RS while being treated with salicylates for ARF. Patient Report.—A 7-year-old girl was admitted to the University of Utah Medical Center, Salt Lake City, for altered mental status. Three weeks prior to admission, References 1. Remington PL, Shabino CL, McGee H, et al: Reye syndrome and juvenile rheumatoid arthritis in Michigan . AJDC 1985;139:870-872. 2. Markowitz M: The decline of rheumatic fever . J Pediatr 1985;106:545-550.Crossref 3. Cullity GJ, Kakulas BA: Encephalopathy and fatty degeneration of the viscera . Brain 1970;93:77-88.Crossref 4. Johnson GM, Scurletis TD, Carroll NB: A study of 16 fatal cases of encephalitis-like disease in North Carolina children . NC Med J 1963;24: 464-473. 5. Rennebohm RM, Heibi JE, Daughtery CC, et al: Reye syndrome in children receiving salicylate therapy for connective tissue disease . J Pediatr 1985;107:877-880.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Reye Syndrome and Aspirin Therapy

Abstract

Abstract Sir.—A significant number of children require long-term aspirin therapy for collagen vascular disorders, rheumatic fever, and other inflammatory diseases. Several cases of Reye syndrome (RS) have recently been documented in these children, who may actually be at an increased risk to develop the syndrome.1 Although reports indicate a decline in the incidence of acute rheumatic fever (ARF),2 a recent dramatic resurgence of ARF has occurred in Utah. This resurgence is reflected in...
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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1986.02140240012002
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—A significant number of children require long-term aspirin therapy for collagen vascular disorders, rheumatic fever, and other inflammatory diseases. Several cases of Reye syndrome (RS) have recently been documented in these children, who may actually be at an increased risk to develop the syndrome.1 Although reports indicate a decline in the incidence of acute rheumatic fever (ARF),2 a recent dramatic resurgence of ARF has occurred in Utah. This resurgence is reflected in the increased number of ARF admitted to Primary Children's Hospital, Salt Lake City, in 1985: Average No. Period of Cases 1960-1964 24.6 1965-1969 18.0 1970-1974 14.2 1975-1979 5.0 1980-1984 7.6 1985 50 (Actual No.) We describe herein a child who developed RS while being treated with salicylates for ARF. Patient Report.—A 7-year-old girl was admitted to the University of Utah Medical Center, Salt Lake City, for altered mental status. Three weeks prior to admission, References 1. Remington PL, Shabino CL, McGee H, et al: Reye syndrome and juvenile rheumatoid arthritis in Michigan . AJDC 1985;139:870-872. 2. Markowitz M: The decline of rheumatic fever . J Pediatr 1985;106:545-550.Crossref 3. Cullity GJ, Kakulas BA: Encephalopathy and fatty degeneration of the viscera . Brain 1970;93:77-88.Crossref 4. Johnson GM, Scurletis TD, Carroll NB: A study of 16 fatal cases of encephalitis-like disease in North Carolina children . NC Med J 1963;24: 464-473. 5. Rennebohm RM, Heibi JE, Daughtery CC, et al: Reye syndrome in children receiving salicylate therapy for connective tissue disease . J Pediatr 1985;107:877-880.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Oct 1, 1986

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