Abstract • Over an 18-month period, four severe and eight mild cases of retrolental fibroplasia (RLF) were diagnosed. All infants had gestational age less than 34 weeks. While the percentage of infants with RLF increased with decreasing gestational age, the severity of RLF was not related to birth weight or gestational age. These RLF infants were compared with premature infants having normal fundi. The arterial blood gas values in the first week of life were similar for the two groups. However, during the subsequent weeks of oxygen therapy, the infants who developed severe RLF had a significantly greater number of hours of capillary oxygen tension at undesirable levels (Pcap O2 > 50 mm Hg) than the mild RLF or control infants. These results suggest that infants may be at greatest risk of severe retinal damage from oxygen relatively late in the course of their oxygen therapy. References 1. Terry TL: Extreme prematurity and fibroplastic overgrowth of persistent vascular sheath behind each crystalline lens . Am J Ophthalmol 25:203-204, 1942. 2. Campbell K: Intensive oxygen therapy as a possible cause of retrolental fibroplasia: A clinical approach . Med J Aust 2:48-50, 1951. 3. Kinsey VE: Retrolental fibroplasia: Cooperative study of retrolental fibroplasia and the use of oxygen . Arch Ophthalmol 56:481-543, 1956.Crossref 4. Hatfield E: Blindness in infants and young children . Sight Sav Rev 42:69-89, 1972. 5. Patz A: Retrolental fibroplasia . Survey Ophthalmol 14:1-29, 1969. 6. Dubowitz LMS, Dubowitz V, Goldberg C: Clinical assessment of gestational age in the newborn infant . J Pediatr 77:1-10, 1970.Crossref 7. Reese AB, King M, Owens WC: Classification of retrolental fibroplasia . Am J Ophthalmol 36:1333-1335, 1953. 8. Van Kessel AL: Reliable blood gas analysis , in Technical Improvement Service . Chicago, American Society of Clinical Pathologist, 1975, vol 20, pp 10-32. 9. Lubchenco LO, Hansman C, Dressler M, et al: Intrauterine growth as estimated from liveborn birth-weight data at 24 to 42 weeks of gestation . Pediatrics 32:793-800, 1963. 10. Svedbergh B, Lindstedt E: Retrolental fibroplasia in Sweden: General survey and selected study on patients born in 1960-66 . Acta Paediatr Scand 62:458-464, 1973.Crossref 11. Foos RY, Kopelow SM: Development of retinal vasculature in paranatal infants . Survey Ophthalmol 18:117-127, 1973. 12. Brockhurst RJ, Chishti MI: Cicatricial retrolental fibroplasia: Its occurrence without oxygen administration and in full-term infants . Albrecht von Graefes Arch Klin Ophthalmol 195:113-128, 1975.Crossref 13. Bruckner HL: Retrolental fibroplasia—associated with intrauterine anoxia? Arch Ophthalmol 80:504-505, 1968.Crossref 14. Kalina RE, Hodson WA, Morgan BC: Retrolental fibroplasia in a cyanotic infant . Pediatrics 50:765-768, 1972. 15. Karlsberg RC, Green WR, Patz A: Congenital retrolental fibroplasia . Arch Ophthalmol 89:122-123, 1973.Crossref 16. Kraushar MF, Harper RG, Sia CG: Retrolental fibroplasia in a full-term infant . Am J Ophthalmol 80:106-108, 1975. 17. Stefani FH, Ehalt H: Non-oxygen induced retinitis proliferans and retinal detachment in full-term infants . Br J Ophthalmol 58:490-513, 1974.Crossref 18. Zacharias L: Incidence of retrolental fibroplasia . Pediatrics 25:726-727, 1960. 19. Oxygen therapy in the newborn infant, Committee on Fetus and Newborn . Pediatrics 47:1086-1087, 1971. 20. Aranda JV, Sweet AY: Sustained hyperoxemia without cicatricial retrolental fibroplasia . Pediatrics 54:434-439, 1974.
Archives of Ophthalmology – American Medical Association
Published: Jan 1, 1978