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Retinoblastoma: Past, Present, and Future

Retinoblastoma: Past, Present, and Future Abstract From 1805 when retinoblastoma was viewed as merely a bloody fungating lesion called "fungus hematodes" to 1864 when it was correctly identified as a neoplasm and given the pseudonym "glioma," the diagnosis was a simple choice between "amaurotic cat's eye" or scrofula. Then, with the advent of the ophthalmoscope and microscope (1850), the pace quickened so that the diagnostic choice lay between glioma and pseudoglioma. Over the years the pseudogliomas (or leukokorias) have been amplified to include many stimulating lesions such as Coats' disease, persistent hyperplastic vitreous, retrolental fibroplasia, retinal dysplasia, larval granuloma, etc. Now the correct diagnosis can be made in 93% of the eyes with clear media (G. Howard, MD, oral communication, November 1965). The treatment of retinoblastoma has shown an exciting evolution. Even in the 19th century after retinoblastoma was finally recognized as cancer the value of early enucleation as a life-saving measure was seriously contested. Guthrie, References 1. Dunphy, E.B.: The Story of Retinoblastoma , Trans Amer Acad Ophthal Otolaryng 68:249-264, 1964. 2. Stallard, H.B.: Malignant Melanoma of the Choroid, read before the Gonin Society, Munich, Germany, Aug 8, 1966. 3. Williams, C.M., and Greer, M.: Homovanillic Acid and Canilmandelic Acid in Diagnosis of Neuroblastoma , JAMA 183:134, 1963.Crossref 4. Brown, D.H.: The Urinary Excretion of Vanilmandelic Acid (VMA) and Homovanillic Acid (HVA) in Children With Retinoblastoma , Amer J Ophthal 62:239-243 ( (Aug) ) 1966. 5. Polack, F.M.: Incorporation of Tritiated Thymidine by Ocular Tumors in Vitro , Amer J Ophthal 60:46-49 ( (July) ) 1965. 6. Churchill-Davidson, I.; Sanger, C.; and Tomlinson, R.H.: Oxygenation in Radiotherapy , Brit J Radio 30:406-422 ( (Aug) ) 1957.Crossref 7. Sanger, C.: High Pressure Oxygen and Radiation Therapy , Amer J Roentgen 81:498-503 ( (March) ) 1959. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Retinoblastoma: Past, Present, and Future

Archives of Ophthalmology , Volume 77 (3) – Mar 1, 1967

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Publisher
American Medical Association
Copyright
Copyright © 1967 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1967.00980020295001
Publisher site
See Article on Publisher Site

Abstract

Abstract From 1805 when retinoblastoma was viewed as merely a bloody fungating lesion called "fungus hematodes" to 1864 when it was correctly identified as a neoplasm and given the pseudonym "glioma," the diagnosis was a simple choice between "amaurotic cat's eye" or scrofula. Then, with the advent of the ophthalmoscope and microscope (1850), the pace quickened so that the diagnostic choice lay between glioma and pseudoglioma. Over the years the pseudogliomas (or leukokorias) have been amplified to include many stimulating lesions such as Coats' disease, persistent hyperplastic vitreous, retrolental fibroplasia, retinal dysplasia, larval granuloma, etc. Now the correct diagnosis can be made in 93% of the eyes with clear media (G. Howard, MD, oral communication, November 1965). The treatment of retinoblastoma has shown an exciting evolution. Even in the 19th century after retinoblastoma was finally recognized as cancer the value of early enucleation as a life-saving measure was seriously contested. Guthrie, References 1. Dunphy, E.B.: The Story of Retinoblastoma , Trans Amer Acad Ophthal Otolaryng 68:249-264, 1964. 2. Stallard, H.B.: Malignant Melanoma of the Choroid, read before the Gonin Society, Munich, Germany, Aug 8, 1966. 3. Williams, C.M., and Greer, M.: Homovanillic Acid and Canilmandelic Acid in Diagnosis of Neuroblastoma , JAMA 183:134, 1963.Crossref 4. Brown, D.H.: The Urinary Excretion of Vanilmandelic Acid (VMA) and Homovanillic Acid (HVA) in Children With Retinoblastoma , Amer J Ophthal 62:239-243 ( (Aug) ) 1966. 5. Polack, F.M.: Incorporation of Tritiated Thymidine by Ocular Tumors in Vitro , Amer J Ophthal 60:46-49 ( (July) ) 1965. 6. Churchill-Davidson, I.; Sanger, C.; and Tomlinson, R.H.: Oxygenation in Radiotherapy , Brit J Radio 30:406-422 ( (Aug) ) 1957.Crossref 7. Sanger, C.: High Pressure Oxygen and Radiation Therapy , Amer J Roentgen 81:498-503 ( (March) ) 1959.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Mar 1, 1967

References