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Retinoblastoma Among Offspring of Adult Survivors

Retinoblastoma Among Offspring of Adult Survivors Abstract There are reports in the literature of families in which a very high proportion of the members are affected with retinoblastoma. This suggests some factor other than the action of a simple autosomal gene (Fig. 1, Griffith and Sorsby1; Fig. 2, Wilson, cited by Bell2). In 1954 Reese stated that he had seen only one survivor of retinoblastoma with healthy children. At that time 77% of the collected offspring of survivors were affected.3 This high percentage does not conform to the usual pattern for dominant traits, which characteristically produce 50% affected offspring when one parent is genotypically normal and the other is heterozygous. One flaw in the report of Dr. Reese is his method of obtaining family trees from affected children. This immediately weighs the scale in favor of high incidence of affected children. The data were derived from 15 families, each with one parent who had References 1. Griffith, A. D., and Sorsby, A.: The Genetics of Retinoblastoma , Brit. J. Ophthal. 28:279-293, 1944.Crossref 2. Bell, J.: The Treasury of Human Inheritance , London, Cambridge University Press, 1931, Vol. 2, pp. 112-123. 3. Reese, A. B.: Frequency of Retinoblastoma in Progeny of Parents Who Have Survived the Disease , A.M.A. Arch. Ophthal. 52:815-818, 1954.Crossref 4. Steinberg, A. G.: Methodology in Human Genetics , J. Med. Educ. 34:315-335, 1959. 5. Steward, J. K.; Smith, J. L. S., and Arnold, E. L.: Spontaneous Regression of Retinoblastoma , Brit. J. Ophthal. 40:449-461, 1956.Crossref 6. Falls, H. F., and Neel, J. V.: Genetics of Retinoblastoma , A.M.A. Arch. Ophthal. 46:367-389, 1951.Crossref 7. Hemmes, G. D.: Untersuchung nach dem Vorkommen von Glioma retinae bei Verwandten von mit dieser Krankheit behafteten , Klin. Augenheilk. 86:331-335, 1931. 8. Lang, H.: Über Glioma Retinal unter besonderer Berucksichtigung seiner Erblichkeit , Klin. Mbl. Augenheilk. 101:854-861, 1938. 9. Tucker, D. P.; Steinberg, A. G., and Cogan, D. G.: Frequency of Genetic Transmission of Sporadic Retinoblastoma , A.M.A. Arch. Ophthal. 57:532-535, 1957.Crossref 10. Macklin, M. T.: Inheritance of Retinoblastoma in Ohio , A.M.A. Arch. Ophthal. 62: 842-851, 1959.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Retinoblastoma Among Offspring of Adult Survivors

Archives of Ophthalmology , Volume 65 (4) – Apr 1, 1961

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Publisher
American Medical Association
Copyright
Copyright © 1961 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1961.01840020548015
Publisher site
See Article on Publisher Site

Abstract

Abstract There are reports in the literature of families in which a very high proportion of the members are affected with retinoblastoma. This suggests some factor other than the action of a simple autosomal gene (Fig. 1, Griffith and Sorsby1; Fig. 2, Wilson, cited by Bell2). In 1954 Reese stated that he had seen only one survivor of retinoblastoma with healthy children. At that time 77% of the collected offspring of survivors were affected.3 This high percentage does not conform to the usual pattern for dominant traits, which characteristically produce 50% affected offspring when one parent is genotypically normal and the other is heterozygous. One flaw in the report of Dr. Reese is his method of obtaining family trees from affected children. This immediately weighs the scale in favor of high incidence of affected children. The data were derived from 15 families, each with one parent who had References 1. Griffith, A. D., and Sorsby, A.: The Genetics of Retinoblastoma , Brit. J. Ophthal. 28:279-293, 1944.Crossref 2. Bell, J.: The Treasury of Human Inheritance , London, Cambridge University Press, 1931, Vol. 2, pp. 112-123. 3. Reese, A. B.: Frequency of Retinoblastoma in Progeny of Parents Who Have Survived the Disease , A.M.A. Arch. Ophthal. 52:815-818, 1954.Crossref 4. Steinberg, A. G.: Methodology in Human Genetics , J. Med. Educ. 34:315-335, 1959. 5. Steward, J. K.; Smith, J. L. S., and Arnold, E. L.: Spontaneous Regression of Retinoblastoma , Brit. J. Ophthal. 40:449-461, 1956.Crossref 6. Falls, H. F., and Neel, J. V.: Genetics of Retinoblastoma , A.M.A. Arch. Ophthal. 46:367-389, 1951.Crossref 7. Hemmes, G. D.: Untersuchung nach dem Vorkommen von Glioma retinae bei Verwandten von mit dieser Krankheit behafteten , Klin. Augenheilk. 86:331-335, 1931. 8. Lang, H.: Über Glioma Retinal unter besonderer Berucksichtigung seiner Erblichkeit , Klin. Mbl. Augenheilk. 101:854-861, 1938. 9. Tucker, D. P.; Steinberg, A. G., and Cogan, D. G.: Frequency of Genetic Transmission of Sporadic Retinoblastoma , A.M.A. Arch. Ophthal. 57:532-535, 1957.Crossref 10. Macklin, M. T.: Inheritance of Retinoblastoma in Ohio , A.M.A. Arch. Ophthal. 62: 842-851, 1959.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Apr 1, 1961

References