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Retinal Sensitivity Over Drusen and Nondrusen Areas: A Study Using Fundus Perimetry

Retinal Sensitivity Over Drusen and Nondrusen Areas: A Study Using Fundus Perimetry Abstract • Elderly patients with drusen and good visual acuity have a decrease in dark-adapted retinal sensitivity in the central retina. We used the fundus camera stimulator to determine whether this sensitivity loss is caused directly by the presence of drusen. We measured retinal sensitivity over drusen and in drusen-free areas in eight patients with drusen and age-related macular degeneration (AMD). There was no significant difference in sensitivity between drusen and nondrusen areas in each patient. The sensitivity loss seen in patients with drusen thus seems to reflect a more diffuse disease of the retina and retinal pigment epithelium and is not a direct effect of drusen. More marked sensitivity losses are found in even small areas of more advanced AMD changes, suggesting that a large focal loss in retinal sensitivity may be an indicator of developing AMD changes. References 1. Ferris FL III: Senile macular degeneration: Review of epidemiologic features . Am J Epidemiol 1983;118:132-151. 2. Smiddy WE, Fine SL: Prognosis of patients with bilateral macular drusen . Ophthalmology 1984;91:271-277.Crossref 3. Sunness JS, Massof RW, Johnson MA, et al: Peripheral retinal function in age-related macular degeneration . Arch Ophthalmol 1985;103:811-816.Crossref 4. Eisner A, Fleming SA, Klein ML, et al: Sensitivities in older eyes with good acuity: Eyes whose fellow eye has exudative AMD . Invest Ophthalmol Vis Sci 1987;28:1832-1837. 5. Brown B, Adams AJ, Coletta NJ, et al: Dark adaptation in age-related maculopathy . Ophthalmol Physiol Opt 1986;6:81-84.Crossref 6. Sarks SH: Ageing and degeneration in the macular region: A clinico-pathological study . Br J Ophthalmol 1976;60:324-341.Crossref 7. Green WR, McDonnell PJ, Yeo JH: Pathologic features of senile macular degeneration . Ophthalmology 1985;92:615-627.Crossref 8. Sunness JS, Johnson MA, Massof RW, et al: Wilmer fundus camera stimulator . Appl Optics 1987;26:1487-1491.Crossref 9. Harrington DO: The Visual Fields , ed 5. St Louis, CV Mosby Co, 1981, p 99. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Retinal Sensitivity Over Drusen and Nondrusen Areas: A Study Using Fundus Perimetry

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Publisher
American Medical Association
Copyright
Copyright © 1988 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1988.01060140237032
Publisher site
See Article on Publisher Site

Abstract

Abstract • Elderly patients with drusen and good visual acuity have a decrease in dark-adapted retinal sensitivity in the central retina. We used the fundus camera stimulator to determine whether this sensitivity loss is caused directly by the presence of drusen. We measured retinal sensitivity over drusen and in drusen-free areas in eight patients with drusen and age-related macular degeneration (AMD). There was no significant difference in sensitivity between drusen and nondrusen areas in each patient. The sensitivity loss seen in patients with drusen thus seems to reflect a more diffuse disease of the retina and retinal pigment epithelium and is not a direct effect of drusen. More marked sensitivity losses are found in even small areas of more advanced AMD changes, suggesting that a large focal loss in retinal sensitivity may be an indicator of developing AMD changes. References 1. Ferris FL III: Senile macular degeneration: Review of epidemiologic features . Am J Epidemiol 1983;118:132-151. 2. Smiddy WE, Fine SL: Prognosis of patients with bilateral macular drusen . Ophthalmology 1984;91:271-277.Crossref 3. Sunness JS, Massof RW, Johnson MA, et al: Peripheral retinal function in age-related macular degeneration . Arch Ophthalmol 1985;103:811-816.Crossref 4. Eisner A, Fleming SA, Klein ML, et al: Sensitivities in older eyes with good acuity: Eyes whose fellow eye has exudative AMD . Invest Ophthalmol Vis Sci 1987;28:1832-1837. 5. Brown B, Adams AJ, Coletta NJ, et al: Dark adaptation in age-related maculopathy . Ophthalmol Physiol Opt 1986;6:81-84.Crossref 6. Sarks SH: Ageing and degeneration in the macular region: A clinico-pathological study . Br J Ophthalmol 1976;60:324-341.Crossref 7. Green WR, McDonnell PJ, Yeo JH: Pathologic features of senile macular degeneration . Ophthalmology 1985;92:615-627.Crossref 8. Sunness JS, Johnson MA, Massof RW, et al: Wilmer fundus camera stimulator . Appl Optics 1987;26:1487-1491.Crossref 9. Harrington DO: The Visual Fields , ed 5. St Louis, CV Mosby Co, 1981, p 99.

Journal

Archives of Ophthalmology – American Medical Association

Published: Aug 1, 1988

References

  • Senile macular degeneration: Review of epidemiologic features
    Ferris FL III
  • Prognosis of patients with bilateral macular drusen
    Smiddy WE, Fine SL
  • Peripheral retinal function in age-related macular degeneration
    Sunness JS, Massof RW, Johnson MA, et al
  • Sensitivities in older eyes with good acuity: Eyes whose fellow eye has exudative AMD
    Eisner A, Fleming SA, Klein ML, et al
  • Dark adaptation in age-related maculopathy
    Brown B, Adams AJ, Coletta NJ, et al
  • Ageing and degeneration in the macular region: A clinico-pathological study
    Sarks SH
  • Pathologic features of senile macular degeneration
    Green WR, McDonnell PJ, Yeo JH
  • Wilmer fundus camera stimulator
    Sunness JS, Johnson MA, Massof RW, et al
  • The Visual Fields
    Harrington DO