Abstract IN RECENT reports1 we stated that our experience with the use of corticotropin (ACTH) in the early progressive stages of retrolental fibroplasia gave us some hope that it might prove effective. This hope has not been realized. The present paper covers infants born between Dec. 15, 1949, and July 25, 1951. The treatment of infants born during this time was begun between February, 1950, and August, 1951, a 19-month experience. MATERIAL Source of Material Studied. —Cases of retrolental fibroplasia considered in this report occurred in two New York hospitals—Babies Hospital and Lincoln Hospital. Selection of Cases for Treatment. —In selecting the cases for treatment, it was important to make the decision before irreversible fundus changes occurred and, at the same time, not to choose cases in which there was a reasonable chance of spontaneous regression. The only chance of salvaging a useful eye was to arrest the disease before References 1. Reese, A. B., and Blodi, F. C.: Retrolental Fibroplasia: The Fifth Francis I. Proctor Lecture , Am. J. Ophth. 34:1-24, 1951. 2. Blodi, F. C.; Silverman, W. A.; Day, R., and Reese, A. B.: Experiences with Corticotropin (ACTH) in the Acute Stage of Retrolental Fibroplasia , A. M. A. Am. J. Dis. Child. 82:242-245 ( (Aug.) ) 1951. 3. Silverman, W. A.; Day, R. L., and Blodi, F. C.: Inhibition of Growth and Other Effects of ACTH in Premature Infants , Pediatrics 8:177-191, 1951. 4. An equal number of blue and white marbles, of the same size, were kept in a box. When a case of retrolental fibroplasia progressed to the stage that satisfied our criteria for commencing therapy (early progressive retinal edema), a marble was drawn, and the decision to treat or not to treat was made by its color.
A.M.A. Archives of Ophthalmology – American Medical Association
Published: May 1, 1952
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