Abstract THE PURPOSE of this preliminary report is to show the effect of topically applied cortisone in two cases of congenital syphilitic interstitial keratitis. Most syphilologists and ophthalmologists agree that the present therapeutic approach to the treatment of this baffling ocular manifestation of congenital syphilis leaves much to be desired. Penicillin has proved its worth in the treatment of congenital syphilis; in the treatment of syphilitic keratitis, however, penicillin, either alone or combined with artificial fever, frequently fails to bring about rapid and certain resolution of the inflammatory process. The most recent statistics available show that in the continental United States during 1950 there were 13,646 cases of congenital syphilis reported to the Division of Venereal Disease of the United States Public Health Service.1 Stokes reviewed 164 cases brought to medical attention because of heredosyphilis; of these 52% had or had had interstitial keratitis, 26% had other types of ocular References 1. Statistics: Venereal Disease Cases and Rates per 100,000 Population, Continental United States Civilians, Fiscal Year 1950 , J. Ven. Dis. Inform. 32:24 ( (Jan.) ) 1951. 2. Stokes, J. H.; Beerman, H., and Ingraham, N. R.: Modern Clinical Syphilology , ed. 3, Philadelphia, W. B. Saunders Company, 1944, p. 1114. 3. Steffensen, E. H.; Olson, J. A.; Margulis, R. R.; Smith, R. W., and Whitney, E. L.: The Experimental Use of Cortisone in Inflammatory Eye Disease , Am. J. Ophth. 33:1033-1040 ( (July) ) 1950. 4. Geddes, A. K., and McCall, M. F.: Interstitial Keratitis Treated with Cortisone , Canad. M. A. J. 63:601 ( (Dec.) ) 1950. 5. The cortisone acetate (ophthalmic suspension), 2.5% strength (25 mg. per cubic centimeter), was supplied by Merck & Company, Inc., through the courtesy of Dr. Augustus Gibson, Executive Director, Medical Division. 6. Koff, R.; Rome, S.; Kasper, R.; Commons, R. R.; Button, R., and Starr, P.: Subconjunctival Injection of Cortisone in Iritis , J. A. M. A. 144:1259-60 ( (Dec. 9) ) 1950.Crossref 7. Jones, I. S., and Meyer, Karl: Inhibition of Vascularization of the Rabbit Cornea by Local Application of Cortisone , Proc. Soc. Exper. Biol. & Med. 74:102-104 ( (May) ) 1950. 8. Woods, A. C., and Wood, R. M.: The Action of ACTH and Cortisone on Experimental Ocular Inflammation , Bull. Johns Hopkins Hosp. 87:482-504 ( (Nov.) ) 1950. 9. Harvey, A. M.; Howard, J. E., and Kattus, A. A.: The Effect of Adrenocorticotropic Hormone (ACTH) and Cortisone on Certain Diseases of the Eye in Which Hypersensitivity Plays a Role , Bull. Johns Hopkins Hosp. 87:461-481 ( (Nov.) ) 1950.
A.M.A. Archives of Dermatology & Syphilology – American Medical Association
Published: Oct 1, 1951