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RESPONSE TO A STIMULATING INJECTION OF TETANUS TOXOID

RESPONSE TO A STIMULATING INJECTION OF TETANUS TOXOID The purpose of this article is to report the response to a stimulating dose of tetanus toxoid in children previously (one and one-half to two and one-half years) immunized with combined diphtheria and tetanus toxoid, alum precipitated. The report of the initial antitoxin response in the same group of children has already been published.1 The value of active immunization against tetanus is being rapidly recognized by members of the medical profession, and even among the nonmedical population there are many requests for protection against lockjaw. In evaluating the results of a study of this sort, one is handicapped by not knowing the exact relationship between circulating antitoxin and the total immunologic status of a person in any one instance. Such factors as the size of the infecting dose of tetanus spores, the total quantity of blood serum present and the antigenic effect of liberated toxin are unknown quantities when http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

RESPONSE TO A STIMULATING INJECTION OF TETANUS TOXOID

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References (6)

Publisher
American Medical Association
Copyright
Copyright © 1943 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1943.02010200032005
Publisher site
See Article on Publisher Site

Abstract

The purpose of this article is to report the response to a stimulating dose of tetanus toxoid in children previously (one and one-half to two and one-half years) immunized with combined diphtheria and tetanus toxoid, alum precipitated. The report of the initial antitoxin response in the same group of children has already been published.1 The value of active immunization against tetanus is being rapidly recognized by members of the medical profession, and even among the nonmedical population there are many requests for protection against lockjaw. In evaluating the results of a study of this sort, one is handicapped by not knowing the exact relationship between circulating antitoxin and the total immunologic status of a person in any one instance. Such factors as the size of the infecting dose of tetanus spores, the total quantity of blood serum present and the antigenic effect of liberated toxin are unknown quantities when

Journal

American journal of diseases of children – American Medical Association

Published: Aug 1, 1943

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