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Response of Renal Allografts to Erythropoietic Stimuli: In the Presence of Immunosuppression

Response of Renal Allografts to Erythropoietic Stimuli: In the Presence of Immunosuppression Abstract Erythropoietin (ESF) is a hormone of renal origin active in the regulation of red cell production.1 Various factors or stimuli are known to result in ESF release. These include bleeding,2 hypoxic hypoxia exposure,3 exogenous androgen administration,4 or cobalt chloride treatment.5 Autotransplanted canine kidneys can respond to various erythropoietic stimuli as can normal intact kidneys.6 The present experiments were conducted to test further the response of animals with renal allografts, with and without various forms of immunosuppression to various erythropoietic stimuli. Materials and Methods Adult male and female mongrel dogs, in healthy condition, underwent bilateral nephrectomy and received a kidney from an unrelated donor. Postoperatively, animals with functioning grafts were either untreated or given yeast respiratory extract (PCO),7 50 mg/kg every other day; azathioprine (Imuran), 5 mg/kg daily, or azathioprine and PCO in similar but combined fashion. Routine biochemical and hematological preoperative and postoperative References 1. Gordon, A.S.: Hemopoietine , Physiol Rev 39:1-40 ( (Jan) ) 1959. 2. Mirand, E.A., et al: Erythropoietin Response to Repeated Hemorrhage in Renal Autotransplanted Nephrectomized, or Intact Dogs , Life Sci 7:689-695 ( (July) ) 1968.Crossref 3. Fisher, J.W., et al: Effects of Cobalt on Activity of Sheep Erythropoietin in Rat Kidney Homogenates , Proc Soc Exp Biol Med 122:1015-1018 ( (Aug) -Sept) 1966.Crossref 4. Mirand, E.A., et al: Effects of Testosterone on Renal Hemodynamics and Erythropoietin Release in Dogs , Invest Urol 4:203-207 ( (Nov) ) 1966. 5. Fisher, J.W., and Langston, J.W.: The Influence of Hypoxemia and Cobalt on Erythropoietin Production in the Isolated Perfused Dog Kidney , Blood 29:114-125 ( (Jan) ) 1967. 6. Murphy, G.P., et al: Erythropoietin Activity in Autotransplanted Canine Kidneys , Arch Surg 99:660-663 ( (Nov) ) 1969.Crossref 7. Murphy, G.P., et al: The Effect of PCO (Yeast Respiratory Stimulator) on Imuran-treated and Untreated Dog Renal Allografts , Surg Forum 20:299-301 ( (Oct) ) 1969. 8. Mirand, E.A.; Prentice, T.C.; and Slaunwhite, W.R.: Current Studies on the Role of Erythropoietin on Erythropoiesis , Ann NY Acad Sci 77:677-702 ( (Jan) ) 1959.Crossref 9. Mirand, E.A., and Murphy, G.P.: Erythropoietin Alterations in Patients With Uremia, Renal Allografts, or Without Kidneys , JAMA 209:392-398 ( (July) ) 1969.Crossref 10. Mirand, E.A.: Extrarenal and Renal Control of Erythropoietin Production , Ann NY Acad Sci 149:94-106 ( (March) ) 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Surgery American Medical Association

Response of Renal Allografts to Erythropoietic Stimuli: In the Presence of Immunosuppression

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References (11)

Publisher
American Medical Association
Copyright
Copyright © 1970 American Medical Association. All Rights Reserved.
ISSN
0004-0010
eISSN
1538-3644
DOI
10.1001/archsurg.1970.01340190022007
Publisher site
See Article on Publisher Site

Abstract

Abstract Erythropoietin (ESF) is a hormone of renal origin active in the regulation of red cell production.1 Various factors or stimuli are known to result in ESF release. These include bleeding,2 hypoxic hypoxia exposure,3 exogenous androgen administration,4 or cobalt chloride treatment.5 Autotransplanted canine kidneys can respond to various erythropoietic stimuli as can normal intact kidneys.6 The present experiments were conducted to test further the response of animals with renal allografts, with and without various forms of immunosuppression to various erythropoietic stimuli. Materials and Methods Adult male and female mongrel dogs, in healthy condition, underwent bilateral nephrectomy and received a kidney from an unrelated donor. Postoperatively, animals with functioning grafts were either untreated or given yeast respiratory extract (PCO),7 50 mg/kg every other day; azathioprine (Imuran), 5 mg/kg daily, or azathioprine and PCO in similar but combined fashion. Routine biochemical and hematological preoperative and postoperative References 1. Gordon, A.S.: Hemopoietine , Physiol Rev 39:1-40 ( (Jan) ) 1959. 2. Mirand, E.A., et al: Erythropoietin Response to Repeated Hemorrhage in Renal Autotransplanted Nephrectomized, or Intact Dogs , Life Sci 7:689-695 ( (July) ) 1968.Crossref 3. Fisher, J.W., et al: Effects of Cobalt on Activity of Sheep Erythropoietin in Rat Kidney Homogenates , Proc Soc Exp Biol Med 122:1015-1018 ( (Aug) -Sept) 1966.Crossref 4. Mirand, E.A., et al: Effects of Testosterone on Renal Hemodynamics and Erythropoietin Release in Dogs , Invest Urol 4:203-207 ( (Nov) ) 1966. 5. Fisher, J.W., and Langston, J.W.: The Influence of Hypoxemia and Cobalt on Erythropoietin Production in the Isolated Perfused Dog Kidney , Blood 29:114-125 ( (Jan) ) 1967. 6. Murphy, G.P., et al: Erythropoietin Activity in Autotransplanted Canine Kidneys , Arch Surg 99:660-663 ( (Nov) ) 1969.Crossref 7. Murphy, G.P., et al: The Effect of PCO (Yeast Respiratory Stimulator) on Imuran-treated and Untreated Dog Renal Allografts , Surg Forum 20:299-301 ( (Oct) ) 1969. 8. Mirand, E.A.; Prentice, T.C.; and Slaunwhite, W.R.: Current Studies on the Role of Erythropoietin on Erythropoiesis , Ann NY Acad Sci 77:677-702 ( (Jan) ) 1959.Crossref 9. Mirand, E.A., and Murphy, G.P.: Erythropoietin Alterations in Patients With Uremia, Renal Allografts, or Without Kidneys , JAMA 209:392-398 ( (July) ) 1969.Crossref 10. Mirand, E.A.: Extrarenal and Renal Control of Erythropoietin Production , Ann NY Acad Sci 149:94-106 ( (March) ) 1968.Crossref

Journal

Archives of Surgery – American Medical Association

Published: Jan 1, 1970

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