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Response of Generalized Granuloma Annulare to High-Dose Niacinamide

Response of Generalized Granuloma Annulare to High-Dose Niacinamide Abstract • A patient with generalized granuloma annulare experienced resolution of her lesions after six months of treatment with 1,500 mg/day of niacinamide. Niacinamide seems to be a reasonably safe drug that, even at relatively high doses, is associated with a low incidence of side effects. The participation of a delayed hypersensitivity reaction in the pathogenesis of granuloma annulare and possible mechanisms involving niacinamide in this type of reaction are discussed. (Arch Dermatol 1983;119:836-839) References 1. Stankler L, Leslie G: Generalized granuloma annulare: A report of a case and review of the literature . Arch Dermatol 1967;95:509-513.Crossref 2. Dicken CH, Carrington SG, Winkelmann RK: Generalized granuloma annulare . Arch Dermatol 1969;99:556-563.Crossref 3. Eng AM: Erythematous generalized granuloma annulare . Arch Dermatol 1979;115:1210-1211.Crossref 4. Kossard S, Winkelmann RK: Response of generalized granuloma annulare to alkylating agents . Arch Dermatol 1978;114:216-220.Crossref 5. Rudolph RI: Disseminated granuloma annulare treated with low-dose chlorambucil . Arch Dermatol 1979;115:1212-1213.Crossref 6. Laralde J: Granuloma annulare disseminated . Arch Dermatol 1963;87:777. 7. Mondel EH: Disseminated granuloma annulare: Report of a case treated with chloraquine phosphate . Arch Dermatol 1959;79:352.Crossref 8. Beep WE, Wilson-Jones E: Granuloma annulare tuberculin heat tests . Trans St John Hosp Dermatol Soc 1966;52:68-70. 9. Umbert P, Belcher RW, Winkelmann RK: Lymphokines (MIF) in the serum of patients with sarcoidosis and cutaneous granuloma annulare . Br J Dermatol 1976;95:481-485.Crossref 10. Umbert P, Winkelmann RK: Histologic, ultrastructural, and histochemical studies of granuloma annulare . Arch Dermatol 1977;113:1681-1686.Crossref 11. Grange RW, Black MM, Carrington P: Defective neutrophil migration in granuloma annulare, necrobiosis lipoidica, and sarcoidosis . Arch Dermatol 1979;115:32-35.Crossref 12. Kohler IK, Lorincz AL: Erythema elevatum diutinum treated with niacinamide and tetracycline . Arch Dermatol 1980;116:693-695.Crossref 13. Fereira-Marques J: Therapeutic application of massive and increasing doses of nicotinamide . Acta Derm Venereol 1947;27:173-197. 14. Burger DR, Vandenbark AA, Doyle D, et al: Nicotinamide: Suppression of lymphocyte transformation with component identified in human transfer factor . J Immunol 1976;117:797-801. 15. Shinmoyama M, Kawai M, Hoshi Y, et al: Nicotinamide inhibition of 3' 5' cAMP phosphodiesterase in vitro . Biochem Biophys Res Commun 1972;49:1137-1141.Crossref 16. Zackheim HS, Vasily D, Westphal ML, et al: Reaction to nicotinamide . J Am Acad Dermatol 1981;4:736-737.Crossref 17. Hawkins DR: Treatment of schizophrenia based on the medical model . J Schizophr 1968;2:3-10. 18. Hoffer A: Safety, side effects and relative lack of toxicity of nicotinic acid and nicotinamide . Schizophrenia 1969;1:78-87. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Response of Generalized Granuloma Annulare to High-Dose Niacinamide

Archives of Dermatology , Volume 119 (10) – Oct 1, 1983

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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1983.01650340046018
Publisher site
See Article on Publisher Site

Abstract

Abstract • A patient with generalized granuloma annulare experienced resolution of her lesions after six months of treatment with 1,500 mg/day of niacinamide. Niacinamide seems to be a reasonably safe drug that, even at relatively high doses, is associated with a low incidence of side effects. The participation of a delayed hypersensitivity reaction in the pathogenesis of granuloma annulare and possible mechanisms involving niacinamide in this type of reaction are discussed. (Arch Dermatol 1983;119:836-839) References 1. Stankler L, Leslie G: Generalized granuloma annulare: A report of a case and review of the literature . Arch Dermatol 1967;95:509-513.Crossref 2. Dicken CH, Carrington SG, Winkelmann RK: Generalized granuloma annulare . Arch Dermatol 1969;99:556-563.Crossref 3. Eng AM: Erythematous generalized granuloma annulare . Arch Dermatol 1979;115:1210-1211.Crossref 4. Kossard S, Winkelmann RK: Response of generalized granuloma annulare to alkylating agents . Arch Dermatol 1978;114:216-220.Crossref 5. Rudolph RI: Disseminated granuloma annulare treated with low-dose chlorambucil . Arch Dermatol 1979;115:1212-1213.Crossref 6. Laralde J: Granuloma annulare disseminated . Arch Dermatol 1963;87:777. 7. Mondel EH: Disseminated granuloma annulare: Report of a case treated with chloraquine phosphate . Arch Dermatol 1959;79:352.Crossref 8. Beep WE, Wilson-Jones E: Granuloma annulare tuberculin heat tests . Trans St John Hosp Dermatol Soc 1966;52:68-70. 9. Umbert P, Belcher RW, Winkelmann RK: Lymphokines (MIF) in the serum of patients with sarcoidosis and cutaneous granuloma annulare . Br J Dermatol 1976;95:481-485.Crossref 10. Umbert P, Winkelmann RK: Histologic, ultrastructural, and histochemical studies of granuloma annulare . Arch Dermatol 1977;113:1681-1686.Crossref 11. Grange RW, Black MM, Carrington P: Defective neutrophil migration in granuloma annulare, necrobiosis lipoidica, and sarcoidosis . Arch Dermatol 1979;115:32-35.Crossref 12. Kohler IK, Lorincz AL: Erythema elevatum diutinum treated with niacinamide and tetracycline . Arch Dermatol 1980;116:693-695.Crossref 13. Fereira-Marques J: Therapeutic application of massive and increasing doses of nicotinamide . Acta Derm Venereol 1947;27:173-197. 14. Burger DR, Vandenbark AA, Doyle D, et al: Nicotinamide: Suppression of lymphocyte transformation with component identified in human transfer factor . J Immunol 1976;117:797-801. 15. Shinmoyama M, Kawai M, Hoshi Y, et al: Nicotinamide inhibition of 3' 5' cAMP phosphodiesterase in vitro . Biochem Biophys Res Commun 1972;49:1137-1141.Crossref 16. Zackheim HS, Vasily D, Westphal ML, et al: Reaction to nicotinamide . J Am Acad Dermatol 1981;4:736-737.Crossref 17. Hawkins DR: Treatment of schizophrenia based on the medical model . J Schizophr 1968;2:3-10. 18. Hoffer A: Safety, side effects and relative lack of toxicity of nicotinic acid and nicotinamide . Schizophrenia 1969;1:78-87.

Journal

Archives of DermatologyAmerican Medical Association

Published: Oct 1, 1983

References