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RESPONSE OF BLOOD EOSINOPHILES AND PLASMA 17-HYDROXYCORTICOIDS TO INSULIN SHOCK THERAPY: Correlation with Clinical Effects

RESPONSE OF BLOOD EOSINOPHILES AND PLASMA 17-HYDROXYCORTICOIDS TO INSULIN SHOCK THERAPY:... Abstract INTRODUCTION DEEP INSULIN shock therapy for schizophrenia affords an opportunity to study the effect of repeated acute stress in humans and to correlate the measured responses with improvement or nonimprovement of the schizophrenic condition. The effects of acute stress upon certain indices of adrenocortical activity have recently been critically reviewed by Thorn, Jenkins, and Laidlaw,1 and factors controlling the concentration of blood eosinophiles, by Best and his collaborators.2 The acute fall of eosinophiles resulting from large doses of insulin or from electroshock has been frequently observed. However, the effects of repeated acute stress, such as a course of insulin shock therapy upon the eosinophile count and other more direct measurements of adrenocortical activity have not been as thoroughly studied. Furthermore, the changes in the eosinophile count occurring throughout the course of insulin shock therapy are of considerable clinical interest because of the observations of Rud,3 Altschule and associates, References 1. References 1 and 10. 2. References 1 and 2. 3. References 1 and 12. 4. Thorn, G. W.; Jenkins, D., and Laidlaw, J. C.: Adrenal Response to Stress in Man , in Recent Progress in Hormone Rèsearch , New York, Academic Press, Inc., 1953, Vol. 8, p. 171. 5. Best, W. R.; Kark, R. M.; Muehrcke, R. C., and Samter, M.: Clinical Value of Eosinophile Counts and Eosinophile Response Tests , J. A. M. A. 151:702 ( (Feb. 28) ) 1953. 6. Rud, F.: Eosinophile Counts in Health and in Mental Disease , Oslo, Johan Grundt Tanum Forlog, 1947. 7. Altschule, M. D.; Siegel, E. P.; Restaino, R. M., and Parkhurst, B. H.: Blood Eosinophile Leucocytes in Mental Disease , A. M. A. Arch. Neurol. & Psychiat. 67:228 ( (Feb.) ) 1952. 8. Bond, E. D., and Shurley, J. T.: Insulin Therapy and Its Future , Am. J. Psychiat. 103:338 ( (Nov.) ) 1946. 9. Pilot, M. L.: Use of Base in Fluids for Counting Eosinophiles: A Method for Staining Eosinophiles , Am. J. Clin. Path. 20:870 ( (Sept.) ) 1950. 10. Nelson, D. H., and Samuels, L. T.: A Method for the Determination of 17-Hydroxycorticosteroids in Blood: 17-Hydroxycorticosterone in the Peripheral Circulation , J. Clin. Endocrinol. 12:519 ( (May) ) 1952. 11. Muehrcke, R. C.; Eckert, E. L., and Kark, R. M.: A Statistical Study of Absolute Eosinophile Cell Counts in Healthy Young Adults Using Logarithmic Analysis , J. Lab. & Clin. Med. 40:161 ( (Aug.) ) 1952. 12. Mann, A., and Lehmann, H.: Eosinophile Level in Psychiatric Conditions , Canad. M. A. J. 66:52 ( (Jan.) ) 1952. 13. Hardy, J. D.; Richardson, E. M., and Dohan, F. C.: Urinary Excretion of Corticoids and 17Ketosteroids Following Major Operations: Correlation with Other Aspects of Metabolism , Surg., Gynec. & Obst. 96:448, 1953. 14. Bliss, E. L.; Nelson, D. H., and Samuels, L. T.: Effects of Intravenous ACTH on Blood Levels of 17-Hydroxycorticosteroids and Circulating Leukocytes , J. Clin. Endocrinol. 14:423 ( (April) ) 1954. 15. Jennings, P. B.: Adrenal Cortical Function at Death as Measured by Level of Circulating Eosinophils , Brit. M. J. 1:1055 ( (May) ) 1952. 16. Doe, R. P.; Flink, E. B., and Flint, M. G.: Correlation of Diurnal Variations in Eosinophils and 17-Hydroxycorticosteroids in Plasma and Urine , J. Clin. Endocrinol. 14:774 ( (July) ) 1954. 17. Freeman, R. V.; Jones, T. E., and Palmer, J. J.: Three-Year Follow-Up of Patients Developing Eosinophilia During Insulin Coma Therapy , A. M. A. Arch. Neurol. & Psychiat. 71:501, 1954. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Neurology & Psychiatry American Medical Association

RESPONSE OF BLOOD EOSINOPHILES AND PLASMA 17-HYDROXYCORTICOIDS TO INSULIN SHOCK THERAPY: Correlation with Clinical Effects

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Publisher
American Medical Association
Copyright
Copyright © 1955 American Medical Association. All Rights Reserved.
ISSN
0096-6886
DOI
10.1001/archneurpsyc.1955.02330070049007
Publisher site
See Article on Publisher Site

Abstract

Abstract INTRODUCTION DEEP INSULIN shock therapy for schizophrenia affords an opportunity to study the effect of repeated acute stress in humans and to correlate the measured responses with improvement or nonimprovement of the schizophrenic condition. The effects of acute stress upon certain indices of adrenocortical activity have recently been critically reviewed by Thorn, Jenkins, and Laidlaw,1 and factors controlling the concentration of blood eosinophiles, by Best and his collaborators.2 The acute fall of eosinophiles resulting from large doses of insulin or from electroshock has been frequently observed. However, the effects of repeated acute stress, such as a course of insulin shock therapy upon the eosinophile count and other more direct measurements of adrenocortical activity have not been as thoroughly studied. Furthermore, the changes in the eosinophile count occurring throughout the course of insulin shock therapy are of considerable clinical interest because of the observations of Rud,3 Altschule and associates, References 1. References 1 and 10. 2. References 1 and 2. 3. References 1 and 12. 4. Thorn, G. W.; Jenkins, D., and Laidlaw, J. C.: Adrenal Response to Stress in Man , in Recent Progress in Hormone Rèsearch , New York, Academic Press, Inc., 1953, Vol. 8, p. 171. 5. Best, W. R.; Kark, R. M.; Muehrcke, R. C., and Samter, M.: Clinical Value of Eosinophile Counts and Eosinophile Response Tests , J. A. M. A. 151:702 ( (Feb. 28) ) 1953. 6. Rud, F.: Eosinophile Counts in Health and in Mental Disease , Oslo, Johan Grundt Tanum Forlog, 1947. 7. Altschule, M. D.; Siegel, E. P.; Restaino, R. M., and Parkhurst, B. H.: Blood Eosinophile Leucocytes in Mental Disease , A. M. A. Arch. Neurol. & Psychiat. 67:228 ( (Feb.) ) 1952. 8. Bond, E. D., and Shurley, J. T.: Insulin Therapy and Its Future , Am. J. Psychiat. 103:338 ( (Nov.) ) 1946. 9. Pilot, M. L.: Use of Base in Fluids for Counting Eosinophiles: A Method for Staining Eosinophiles , Am. J. Clin. Path. 20:870 ( (Sept.) ) 1950. 10. Nelson, D. H., and Samuels, L. T.: A Method for the Determination of 17-Hydroxycorticosteroids in Blood: 17-Hydroxycorticosterone in the Peripheral Circulation , J. Clin. Endocrinol. 12:519 ( (May) ) 1952. 11. Muehrcke, R. C.; Eckert, E. L., and Kark, R. M.: A Statistical Study of Absolute Eosinophile Cell Counts in Healthy Young Adults Using Logarithmic Analysis , J. Lab. & Clin. Med. 40:161 ( (Aug.) ) 1952. 12. Mann, A., and Lehmann, H.: Eosinophile Level in Psychiatric Conditions , Canad. M. A. J. 66:52 ( (Jan.) ) 1952. 13. Hardy, J. D.; Richardson, E. M., and Dohan, F. C.: Urinary Excretion of Corticoids and 17Ketosteroids Following Major Operations: Correlation with Other Aspects of Metabolism , Surg., Gynec. & Obst. 96:448, 1953. 14. Bliss, E. L.; Nelson, D. H., and Samuels, L. T.: Effects of Intravenous ACTH on Blood Levels of 17-Hydroxycorticosteroids and Circulating Leukocytes , J. Clin. Endocrinol. 14:423 ( (April) ) 1954. 15. Jennings, P. B.: Adrenal Cortical Function at Death as Measured by Level of Circulating Eosinophils , Brit. M. J. 1:1055 ( (May) ) 1952. 16. Doe, R. P.; Flink, E. B., and Flint, M. G.: Correlation of Diurnal Variations in Eosinophils and 17-Hydroxycorticosteroids in Plasma and Urine , J. Clin. Endocrinol. 14:774 ( (July) ) 1954. 17. Freeman, R. V.; Jones, T. E., and Palmer, J. J.: Three-Year Follow-Up of Patients Developing Eosinophilia During Insulin Coma Therapy , A. M. A. Arch. Neurol. & Psychiat. 71:501, 1954.

Journal

A.M.A. Archives of Neurology & PsychiatryAmerican Medical Association

Published: Jan 1, 1955

References