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RESISTANT EROSIVE LESIONS IN PACHYONYCHIA CONGENITA OF JADASSOHN: TREATMENT WITH BUFFERED CYSTEINE HYDROCHLORIDE

RESISTANT EROSIVE LESIONS IN PACHYONYCHIA CONGENITA OF JADASSOHN: TREATMENT WITH BUFFERED... Abstract The purpose of this paper is not to report a case of pachyonychia congenita of Jadassohn, which has been excellently described by Tauber, Goldman and Claassen,1 Sohrweide,2 Andrews and Strumwasser>3 and Diasio,4 or to summarize the thorough reports of Hammett and Reimann>5 and Brunsting and Simonsen>6 on the sulfhydryl groups, but to demonstrate the value of buffered cysteine hydrochloride in other conditions than ulcerated lesions. I wish to report here the progress of a girl, aged 20, previously presented by Tauber and his associates. She had had persistent and resistant foul-smelling erosive lesions for a period of seven years and the condition had failed to respond to innumerable types of therapy. Figure 1 shows the type of lesion which was present, not only on the lateral aspects of the feet, but also on the plantar and posterior portions in symmetrical fashion. The lesions were References 1. Tauber, E. B.; Goldman, L., and Claassen, H.: Pachyonychia Congenita , J. A. M. A. 107:29-30 ( (July 4) ) 1936.Crossref 2. Sohrweide, A. W.: Pachyonychia Congenita: Report of a Case , Arch. Dermat. & Syph. 32:370-376 ( (Sept.) ) 1935. 3. Andrews, G. C., and Strumwasser, S.: Pachyonychia Congenita , New York State J. Med. 29:747-749 ( (June 15) ) 1929. 4. Diasio, F. A.: Pachyonychia Congenita Jadassohn , Arch. Dermat. & Syph. 30:218-226 ( (Aug.) ) 1934. 5. Hammett, F. S., and Reimann, S. P.: Cell Proliferation Response to Sulfhydryl in Mammals , J. Exper. Med. 50:445-448 ( (Oct.) ) 1929. 6. Brunsting, L. A., and Simonsen, D. G.: Cutaneous Ulcers Treated by Sulphydryl Containing Amino-Acid Cysteine , J. A. M. A. 101: 1937-1940 ( (Dec. 16) ) 1933. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology and Syphilology American Medical Association

RESISTANT EROSIVE LESIONS IN PACHYONYCHIA CONGENITA OF JADASSOHN: TREATMENT WITH BUFFERED CYSTEINE HYDROCHLORIDE

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Publisher
American Medical Association
Copyright
Copyright © 1937 American Medical Association. All Rights Reserved.
ISSN
0096-6029
DOI
10.1001/archderm.1937.01480020087013
Publisher site
See Article on Publisher Site

Abstract

Abstract The purpose of this paper is not to report a case of pachyonychia congenita of Jadassohn, which has been excellently described by Tauber, Goldman and Claassen,1 Sohrweide,2 Andrews and Strumwasser>3 and Diasio,4 or to summarize the thorough reports of Hammett and Reimann>5 and Brunsting and Simonsen>6 on the sulfhydryl groups, but to demonstrate the value of buffered cysteine hydrochloride in other conditions than ulcerated lesions. I wish to report here the progress of a girl, aged 20, previously presented by Tauber and his associates. She had had persistent and resistant foul-smelling erosive lesions for a period of seven years and the condition had failed to respond to innumerable types of therapy. Figure 1 shows the type of lesion which was present, not only on the lateral aspects of the feet, but also on the plantar and posterior portions in symmetrical fashion. The lesions were References 1. Tauber, E. B.; Goldman, L., and Claassen, H.: Pachyonychia Congenita , J. A. M. A. 107:29-30 ( (July 4) ) 1936.Crossref 2. Sohrweide, A. W.: Pachyonychia Congenita: Report of a Case , Arch. Dermat. & Syph. 32:370-376 ( (Sept.) ) 1935. 3. Andrews, G. C., and Strumwasser, S.: Pachyonychia Congenita , New York State J. Med. 29:747-749 ( (June 15) ) 1929. 4. Diasio, F. A.: Pachyonychia Congenita Jadassohn , Arch. Dermat. & Syph. 30:218-226 ( (Aug.) ) 1934. 5. Hammett, F. S., and Reimann, S. P.: Cell Proliferation Response to Sulfhydryl in Mammals , J. Exper. Med. 50:445-448 ( (Oct.) ) 1929. 6. Brunsting, L. A., and Simonsen, D. G.: Cutaneous Ulcers Treated by Sulphydryl Containing Amino-Acid Cysteine , J. A. M. A. 101: 1937-1940 ( (Dec. 16) ) 1933.

Journal

Archives of Dermatology and SyphilologyAmerican Medical Association

Published: Aug 1, 1937

References

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