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RESISTANCE TO PROTAMINE ZINC INSULIN WITHOUT RESISTANCE TO REGULAR INSULIN IN DIABETES MELLITUS

RESISTANCE TO PROTAMINE ZINC INSULIN WITHOUT RESISTANCE TO REGULAR INSULIN IN DIABETES MELLITUS Temporary resistance to insulin in diabetes mellitus is not an uncommon occurrence, but resistance to one type of insulin without resistance to another is rare. It is for this reason that we are reporting a case in which there was resistance to protamine zinc insulin and not to regular insulin. REPORT OF CASE A white woman aged 27, single, entered the University Hospital Aug. 3, 1938, because of an acute inflammation of the left external ear and diabetic acidosis. Diabetes mellitus had been present for eleven years and had been treated haphazardly with insulin and modifications of the diet. Growth ceased shortly after the appearance of the diabetes, and the secondary sex characteristics did not develop nor did menstruation occur. For six months prior to admission the diabetes became more severe and was not adequately controlled, although more vigorous treatment was instituted. A furuncle developed in the left external auditory http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

RESISTANCE TO PROTAMINE ZINC INSULIN WITHOUT RESISTANCE TO REGULAR INSULIN IN DIABETES MELLITUS

Greene, James A.; Thatcher, O. D.
JAMA , Volume 113 (27) – Dec 30, 1939
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References (2)

Publisher
American Medical Association
Copyright
Copyright © 1939 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1939.72800520002007a
Publisher site
See Article on Publisher Site

Abstract

Temporary resistance to insulin in diabetes mellitus is not an uncommon occurrence, but resistance to one type of insulin without resistance to another is rare. It is for this reason that we are reporting a case in which there was resistance to protamine zinc insulin and not to regular insulin. REPORT OF CASE A white woman aged 27, single, entered the University Hospital Aug. 3, 1938, because of an acute inflammation of the left external ear and diabetic acidosis. Diabetes mellitus had been present for eleven years and had been treated haphazardly with insulin and modifications of the diet. Growth ceased shortly after the appearance of the diabetes, and the secondary sex characteristics did not develop nor did menstruation occur. For six months prior to admission the diabetes became more severe and was not adequately controlled, although more vigorous treatment was instituted. A furuncle developed in the left external auditory

Journal

JAMA – American Medical Association

Published: Dec 30, 1939

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