Abstract Necrosis of the renal tubular epithelium is uncommonly encountered in newly born infants. In cases of symmetrical cortical necrosis, all elements are destroyed in areas of ischemic necrosis,1,2 but selective tubular necrosis is limited to a few conditions. Lower nephron nephrosis or acute tubular necrosis, as we know it in adults and older children,3 is rarely encountered during the first month of life, and in this laboratory we have seen it only once during the first week of life. Necrobiosis of individual tubular epithelial cells may be found in infections with the virus of cytomegalic inclusion disease or herpes simplex, and the involvement is patchy. Atrophy and severe degeneration of the tubules may accompany hypoplasia with cyst formation, nephrotic syndrome,4,5 and interstitial or chronic nephritis6,7 in newborn infants, but frank necrosis of the tubular epithelium has not been described except in suppurative nephritides. In a survey References 1. Campbell, A. C. P., and Henderson, J. L.: Symmetrical Cortical Necrosis of the Kidneys in Infancy and Childhood , Arch. Dis. Childhood 24: 269 ( (Dec.) ) 1949.Crossref 2. Zuelzer, W. W.; Charles, S.; Kurnetz, R.; Newton, W. A., Jr., and Fallon, R.: Circulatory Diseases of the Kidneys in Infancy and Childhood , A. M. A. Am. J. Dis. Child. 81:1 ( (Jan.) ) 1951. 3. Lucké, B.: Lower Nephron Nephrosis (Renal Lesions of Crush Syndrome, of Burns, Transfusions, and Other Conditions Affecting Lower Segments of Nephrons) , Mil. Surgeon 99:371 ( (Nov.) ) 1946. 4. Eiben, R. M.; Kleinerman, J., and Cline, J. C.: Nephrotic Syndrome in a Neonatal Premature Infant , J. Pediat. 44:195 ( (Feb.) ) 1954.Crossref 5. Giles, H. McC.; Pugh, R. C. B.; Darmady, E. M.; Stranack, F., and Woolf, L. I.: The Nephrotic Syndrome in Early Infancy: A Report of 3 Cases , Arch. Dis. Childhood 32:167 ( (June) ) 1957.Crossref 6. Mitchell, A. G.: Nephrosclerosis (Chronic Interstitial Nephritis) in Childhood: With Special Reference to Renal Rickets , Am. J. Dis. Child. 40: 101 ( (July) ) 1930.Crossref 7. Collins, R. D.: Chronic Glomerulonephritis in a Newborn Child , A. M. A. Am. J. Dis. Child. 87:478 ( (April) ) 1954. 8. Jonsson, B.: Lower Nephron Nephrosis in Asphyxia Neonatorum , Acta pediat. 40:401 ( (Sept.) ) 1951.Crossref 9. Kessel, I., and Pepler, W. J.: Lower Nephron Nephrosis in the Newborn , J. Obst. & Gynaec. Brit. Emp. 62:98 ( (Feb.) ) 1955. 10. Oliver, J.; MacDowell, M., and Tracy, A.: The Pathogenesis of Acute Renal Failure Associated with Traumatic and Toxic Injury: Renal Ischemia, Nephrotoxic Damage and the Ischemuric Episode , J. Clin. Invest. 30:1305 ( (Dec.) , Pt. 1) 1951. 11. Von Glahn, W. C.: Necrosis of the Islands of Langerhans in Renal Insufficiency: Report of 3 Cases , Lab. Invest. 5:236 ( (March) -April) 1956. 12. Landing, B. H., and Bernstein, J.: Unpublished observations. 13. Gruenwald, P.: Asphyxia, Trauma and Shock at Birth , Arch. Pediat. 67:103 ( (March) ) 1950.
A.M.A. Journal of Diseases of Children – American Medical Association
Published: Dec 1, 1958