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Renal Tubular Acidosis Caused By Degraded Tetracycline

Renal Tubular Acidosis Caused By Degraded Tetracycline Abstract Occurrence of the "Fanconi syndrome" following ingestion of outdated or degraded tetracycline has been reported.1,2 We have studied a patient who presented with severe metabolic acidosis after taking outdated tetracycline. Ammonium chloride loading demonstrated a renal tubular defect for hydrogen ion excretion. One and one-half years later the patient was again studied, and this renal tubular function was normal. Report of a Case A 39-year-old woman, admitted to the University Hospital on Sept 3, 1961, had noted increased urinary frequency without dysuria ten days prior to admission. At that time 2+ albumin and many white blood cells and bacteria were found in the urine. She was given a prescription for tetracycline but instead of purchasing capsules she took some dispensed five to six years previously. Her urinary tract symptoms improved; but she developed anorexia, nausea, and vomiting which were treated with prochlorperazine (Compazine), 15 mg per day. There was References 1. Gross, J. M.: Fanconi Syndrome (Adult Type) Developing Secondary to Ingestion of Outdated Tetracycline , Ann Intern Med 58:523-528 ( (March) ) 1963.Crossref 2. Frimpter, G. W., et al: Reversible "Fanconi Syndrome" Caused by Degraded Tetracycline , JAMA 184:111-113 ( (April 13) ) 1963.Crossref 3. Elkinton, J. R., et al: Renal Excretion of Hydrogen Ion in Renal Tubular Acidosis: I. Quantitative Assessment of Response to Ammonium Chloride as Acid Load , Amer J Med 29:554-575 ( (Oct) ) 1960.Crossref 4. Shils, M. E.: Renal Disease and Metabolic Effects of Tetracycline , Ann Intern Med 58:389-408 ( (March) ) 1963.Crossref 5. Gabuzda, G. J., et al: Some Effects of Antibiotics on Nutrition in Man , AMA Arch Intern Med 101:476-513 ( (Feb) ) 1958.Crossref 6. Frimpter, G. W., et al: Observations on Degraded Tetracycline , JAMA 185:414 ( (Aug 3) ) 1963.Crossref 7. Yaffe, S. J.; Craig, J. M.; and Fellers, F. X.: Studies on Renal Enzymes in Patient With Renal Tubular Acidosis , Amer J Med 29:168-175 ( (July) ) 1960.Crossref 8. Berliner, R. W.; Kennedy, T. J.; and Hilton, J. G.: Effect of Maleic Acid on Renal Function , Proc Soc Exp Biol Med 75:791-794 ( (Dec) ) 1950.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Renal Tubular Acidosis Caused By Degraded Tetracycline

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Publisher
American Medical Association
Copyright
Copyright © 1964 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1964.03860080082007
Publisher site
See Article on Publisher Site

Abstract

Abstract Occurrence of the "Fanconi syndrome" following ingestion of outdated or degraded tetracycline has been reported.1,2 We have studied a patient who presented with severe metabolic acidosis after taking outdated tetracycline. Ammonium chloride loading demonstrated a renal tubular defect for hydrogen ion excretion. One and one-half years later the patient was again studied, and this renal tubular function was normal. Report of a Case A 39-year-old woman, admitted to the University Hospital on Sept 3, 1961, had noted increased urinary frequency without dysuria ten days prior to admission. At that time 2+ albumin and many white blood cells and bacteria were found in the urine. She was given a prescription for tetracycline but instead of purchasing capsules she took some dispensed five to six years previously. Her urinary tract symptoms improved; but she developed anorexia, nausea, and vomiting which were treated with prochlorperazine (Compazine), 15 mg per day. There was References 1. Gross, J. M.: Fanconi Syndrome (Adult Type) Developing Secondary to Ingestion of Outdated Tetracycline , Ann Intern Med 58:523-528 ( (March) ) 1963.Crossref 2. Frimpter, G. W., et al: Reversible "Fanconi Syndrome" Caused by Degraded Tetracycline , JAMA 184:111-113 ( (April 13) ) 1963.Crossref 3. Elkinton, J. R., et al: Renal Excretion of Hydrogen Ion in Renal Tubular Acidosis: I. Quantitative Assessment of Response to Ammonium Chloride as Acid Load , Amer J Med 29:554-575 ( (Oct) ) 1960.Crossref 4. Shils, M. E.: Renal Disease and Metabolic Effects of Tetracycline , Ann Intern Med 58:389-408 ( (March) ) 1963.Crossref 5. Gabuzda, G. J., et al: Some Effects of Antibiotics on Nutrition in Man , AMA Arch Intern Med 101:476-513 ( (Feb) ) 1958.Crossref 6. Frimpter, G. W., et al: Observations on Degraded Tetracycline , JAMA 185:414 ( (Aug 3) ) 1963.Crossref 7. Yaffe, S. J.; Craig, J. M.; and Fellers, F. X.: Studies on Renal Enzymes in Patient With Renal Tubular Acidosis , Amer J Med 29:168-175 ( (July) ) 1960.Crossref 8. Berliner, R. W.; Kennedy, T. J.; and Hilton, J. G.: Effect of Maleic Acid on Renal Function , Proc Soc Exp Biol Med 75:791-794 ( (Dec) ) 1950.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Aug 1, 1964

References