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Renal Parenchymal Malakoplakia: A Case Associated With Renal Vein Thrombosis and Partial Recovery of Kidney Function

Renal Parenchymal Malakoplakia: A Case Associated With Renal Vein Thrombosis and Partial Recovery... Abstract • A 65-year-old woman with bilateral renal parenchymal malakoplakia and renal vein thrombosis had severe azotemia, bilaterally enlarged kidneys, urinary tract infection, and sepsis. Angiographic studies demonstrated left renal vein thrombosis. A percutaneous kidney biopsy specimen showed the characteristic Michaelis-Gutmann bodies. After therapy with fluid replacement, antibiotics, and long-term anticoagulation, kidney function improved and both kidneys decreased in size. We suggest that, with adequate treatment of urinary tract infection and correction of potential insults to the kidney, progression of this peculiar disease can be prevented. (Arch Intern Med 140:1111-1114, 1980) References 1. Michaelis L, Gutmann C: Ueber einschlüsse in Blasentumoren. Z Klin Med 47:208-215, 1902. 2. Smith BH: Malacoplakia of the urinary tract: A study of 24 cases. Am J Clin Pathol 43:409-417, 1965. 3. Cadnapaphornchai P, Rosenberg BF, Taher S, et al: Renal parenchymal malakoplakia: An unusual cause of renal failure. N Engl J Med 299:1110-1113,1978.Crossref 4. Von Hansemann D: Ueber malakoplakie der Harnblase. Virchows Arch Pathol Anat 173:302-308, 1903.Crossref 5. Melicow MM: Malacoplakia: Report of a case, review of the literature. J Urol 78:33-40, 1957. 6. Yunis EJ, Estevez JM, Pinzon GJ, et al: Malacoplakia: Discussion of pathogenesis and report of three cases including one of fatal gastric and colonic involvement. Arch Pathol 83:180-187, 1967. 7. González-Angulo A, Corral E, García-Torres R, et al: Malakoplakia of the colon. Gastroenterology 48:383-387, 1965. 8. Brickman RD, Fisher RD, Haller JA: Vena cava thrombosis after plication for pulmonary emboli: Subsequent phlegmasia cerulea dolens, thrombosis of right renal vein and acute nephrosis. JAMA 196:911-912, 1966.Crossref 9. Pringle A, Smith EKM: Renal vein thrombosis in acute hyperparathyroidism Br Med J 2:675-676, 1964.Crossref 10. McFarland JB: Renal vein thrombosis in children. Q J Med 34:269-290, 1965. 11. Simon AL: Normal renal size: An absolute criterion. AJR 92:270-272, 1964. 12. Ravel R: Megalocytic interstitial nephritis: An entity probably related to malakoplakia. Am J Clin Pathol 47:781-789, 1967. 13. Goodman M, Curry T, Russell T: Xanthogranulomatous pyelonephritis: A local disease with systemic manifestations. Medicine 58:171-181, 1979.Crossref 14. Lou TY, Teplitz C: Malakoplakia: Pathogenesis and ultrastructural morphogenesis: A problem of altered macrophage (phagolysozomal) response. Hum Pathol 5:191-207, 1974.Crossref 15. Lewin KJ, Fair WR, Steigbigel RT, et al: Clinical and laboratory studies into the pathogenesis of malacoplakia. J Clin Pathol 29:354-363, 1976.Crossref 16. Abdou NI, NaPombejara C, Sagawa A, et al: Malakoplakia: Evidence for monocyte lysosomal abnormality correctable by cholinergic agonist in vitro and in vivo. N Engl J Med 297:1413-1419, 1977.Crossref 17. Oliver JM: Impaired microtubule function correctable by cyclic GMP and cholinergic agonists in the Chediak-Higashi syndrome. Am J Pathol 85:395-418, 1976. 18. Zurier RB, Weissmann G, Huffstein S, et al: Mechanisms of lysosomal enzyme release from human leukocytes: II. Effects of cAMP and cGMP autonomic agonist, and agents which affect microtubule function. J Clin Invest 53:297-309,1974.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Renal Parenchymal Malakoplakia: A Case Associated With Renal Vein Thrombosis and Partial Recovery of Kidney Function

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1980.00330190123041
Publisher site
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Abstract

Abstract • A 65-year-old woman with bilateral renal parenchymal malakoplakia and renal vein thrombosis had severe azotemia, bilaterally enlarged kidneys, urinary tract infection, and sepsis. Angiographic studies demonstrated left renal vein thrombosis. A percutaneous kidney biopsy specimen showed the characteristic Michaelis-Gutmann bodies. After therapy with fluid replacement, antibiotics, and long-term anticoagulation, kidney function improved and both kidneys decreased in size. We suggest that, with adequate treatment of urinary tract infection and correction of potential insults to the kidney, progression of this peculiar disease can be prevented. (Arch Intern Med 140:1111-1114, 1980) References 1. Michaelis L, Gutmann C: Ueber einschlüsse in Blasentumoren. Z Klin Med 47:208-215, 1902. 2. Smith BH: Malacoplakia of the urinary tract: A study of 24 cases. Am J Clin Pathol 43:409-417, 1965. 3. Cadnapaphornchai P, Rosenberg BF, Taher S, et al: Renal parenchymal malakoplakia: An unusual cause of renal failure. N Engl J Med 299:1110-1113,1978.Crossref 4. Von Hansemann D: Ueber malakoplakie der Harnblase. Virchows Arch Pathol Anat 173:302-308, 1903.Crossref 5. Melicow MM: Malacoplakia: Report of a case, review of the literature. J Urol 78:33-40, 1957. 6. Yunis EJ, Estevez JM, Pinzon GJ, et al: Malacoplakia: Discussion of pathogenesis and report of three cases including one of fatal gastric and colonic involvement. Arch Pathol 83:180-187, 1967. 7. González-Angulo A, Corral E, García-Torres R, et al: Malakoplakia of the colon. Gastroenterology 48:383-387, 1965. 8. Brickman RD, Fisher RD, Haller JA: Vena cava thrombosis after plication for pulmonary emboli: Subsequent phlegmasia cerulea dolens, thrombosis of right renal vein and acute nephrosis. JAMA 196:911-912, 1966.Crossref 9. Pringle A, Smith EKM: Renal vein thrombosis in acute hyperparathyroidism Br Med J 2:675-676, 1964.Crossref 10. McFarland JB: Renal vein thrombosis in children. Q J Med 34:269-290, 1965. 11. Simon AL: Normal renal size: An absolute criterion. AJR 92:270-272, 1964. 12. Ravel R: Megalocytic interstitial nephritis: An entity probably related to malakoplakia. Am J Clin Pathol 47:781-789, 1967. 13. Goodman M, Curry T, Russell T: Xanthogranulomatous pyelonephritis: A local disease with systemic manifestations. Medicine 58:171-181, 1979.Crossref 14. Lou TY, Teplitz C: Malakoplakia: Pathogenesis and ultrastructural morphogenesis: A problem of altered macrophage (phagolysozomal) response. Hum Pathol 5:191-207, 1974.Crossref 15. Lewin KJ, Fair WR, Steigbigel RT, et al: Clinical and laboratory studies into the pathogenesis of malacoplakia. J Clin Pathol 29:354-363, 1976.Crossref 16. Abdou NI, NaPombejara C, Sagawa A, et al: Malakoplakia: Evidence for monocyte lysosomal abnormality correctable by cholinergic agonist in vitro and in vivo. N Engl J Med 297:1413-1419, 1977.Crossref 17. Oliver JM: Impaired microtubule function correctable by cyclic GMP and cholinergic agonists in the Chediak-Higashi syndrome. Am J Pathol 85:395-418, 1976. 18. Zurier RB, Weissmann G, Huffstein S, et al: Mechanisms of lysosomal enzyme release from human leukocytes: II. Effects of cAMP and cGMP autonomic agonist, and agents which affect microtubule function. J Clin Invest 53:297-309,1974.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Aug 1, 1980

References