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Renal Osteodystrophy in Two Siblings

Renal Osteodystrophy in Two Siblings Abstract Recently we observed chronic renal disease with osteodystrophy occurring in two siblings, a boy and a girl. We studied the metabolism of calcium and phosphorus in these children in our metabolic unit before and during therapy with vitamin D. In this report we shall present the clinical findings and the metabolic balance data in this possibly familial metabolic derangement. Report of Cases Case 1.—A 13-year-old boy was seen at the Mayo Clinic in June, 1961, because of knock-knee, tiredness, and pain in the legs. To the parents' recollection this boy had been well until January, 1961, when his father noted that his son had difficulty keeping up with other children while playing basketball.Physical examination revealed a height of 55½ in (140.5 cm) and a weight of 69¼ lb (31.5 kg), both of which were below the third percentile for the patient's age. His blood pressure was 120 mm of References 1. Clark, E. P., and Collip, J. B.: A Study of the Tisdall Method for the Determination of Blood Serum Calcium with a Suggested Modification , J Biol Chem 63:461-464 ( (March) ) 1925. 2. Gomori, G.: A Modification of the Colorimetric Phosphorus Determination for Use With the Photoelectric Colorimeter , J Lab Clin Med 27: 955-960 ( (April) ) 1942. 3. Bonsnes, R. W., and Taussky, H. H.: On the Colorimetric Determination of Creatinine by the Jaffe Reaction , J Biol Chem 158:581-591 ( (May) ) 1945. 4. McGuckin, W. F.: Experience With the Auto-Analyzer in the Analysis of Blood for Sugar and Urea , Clin Chem 5:262 ( (June) ) 1959. 5. Astrup, P.; Jorgensen, K.; Andersen, O. S.; and Engel, K.: The Acid-Base Metabolism: A New Approach , Lancet 1:1035-1039 ( (May 14) ) 1960.Crossref 6. Holth, Tore: Separation of Calcium From Magnesium by Oxalate Method: A Critical Study , Analyt Chem 21:1221-1226 ( (Oct) ) 1949.Crossref 7. Lucas, R. C.: On a Form of Late Rickets Associated With Albuminuria, Rickets of Adolescents , Lancet 1:993-994 ( (June 9) ) 1883.Crossref 8. Fletcher, H. M.: Case of Infantilism With Polyuria and Chronic Renal Disease , Proc Roy Soc Med 4:95 ( (March 24) ) 1911. 9. Mitchell, A. G.: Nephrosclerosis (Chronic Interstitial Nephritis) in Childhood , Amer J Dis Child 40:101-145 ( (July) ) 1930.Crossref 10. Graham, S., and Hutchinson, J. H.: Familial Renal Dwarfism , Arch Dis Child 16:253-256, 1941.Crossref 11. Weill-Hallé, B.; Abaza, A.; and Meunier: Sur l'Étiologie du nanisme rénal: Nanisme familial et nanisme par intoxication au cours de la gestation , Bull Soc Pediat Paris 37:266-273 ( (May) ) 1939. 12. Schneider, R. W., and Corcoran, A. C.: Familial Nephrogenic Osteopathy Due to Excessive Tubular Reabsorption of Inorganic Phosphate: A New Syndrome and a Novel Mode of Relief , J Lab Clin Med 36:985-986 ( (Dec) ) 1950. 13. Danis, P. G., and Rossen, J. A.: Renal Rickets , J Pediat 18:103-116 ( (Jan) ) 1941.Crossref 14. Tobias, G. J.; McLaughlin, R. F., Jr.; and Hopper, J., Jr.: Endogenous Creatinine Clearance: A Valuable Clinical Test of Glomerular Filtration and a Prognostic Guide in Chronic Renal Disease , New Engl J Med 266:317-323 ( (Feb 15) ) 1962.Crossref 15. Stanbury, S. W., and Lumb, G. A.: Metabolic Studies of Renal Osteodystrophy: 1. Calcium, Phosphorus and Nitrogen Metabolism in Rickets, Osteomalacia and Hyperparathyroidism Complicating Chronic Uremia and in the Osteomalacia of the Adult Fanconi Syndrome , Medicine 41:1-28 ( (Feb) ) 1962.Crossref 16. Liu, S. H., and Chu, H. I.: Studies of Calcium and Phosphorus Metabolism with Special Reference to Pathogenesis and Effects of Dihydrotachysterol (A.T. 10) and Iron , Medicine 22:103-161 ( (May) ) 1943.Crossref 17. Dent, C. E.; Harper, C. M.; and Philpot, G. R.: The Treatment of Renal-Glomerular Osteodystrophy , Quart J Med 30:1-31 ( (Jan) ) 1961.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Renal Osteodystrophy in Two Siblings

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References (17)

Publisher
American Medical Association
Copyright
Copyright © 1963 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1963.02080040480010
Publisher site
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Abstract

Abstract Recently we observed chronic renal disease with osteodystrophy occurring in two siblings, a boy and a girl. We studied the metabolism of calcium and phosphorus in these children in our metabolic unit before and during therapy with vitamin D. In this report we shall present the clinical findings and the metabolic balance data in this possibly familial metabolic derangement. Report of Cases Case 1.—A 13-year-old boy was seen at the Mayo Clinic in June, 1961, because of knock-knee, tiredness, and pain in the legs. To the parents' recollection this boy had been well until January, 1961, when his father noted that his son had difficulty keeping up with other children while playing basketball.Physical examination revealed a height of 55½ in (140.5 cm) and a weight of 69¼ lb (31.5 kg), both of which were below the third percentile for the patient's age. His blood pressure was 120 mm of References 1. Clark, E. P., and Collip, J. B.: A Study of the Tisdall Method for the Determination of Blood Serum Calcium with a Suggested Modification , J Biol Chem 63:461-464 ( (March) ) 1925. 2. Gomori, G.: A Modification of the Colorimetric Phosphorus Determination for Use With the Photoelectric Colorimeter , J Lab Clin Med 27: 955-960 ( (April) ) 1942. 3. Bonsnes, R. W., and Taussky, H. H.: On the Colorimetric Determination of Creatinine by the Jaffe Reaction , J Biol Chem 158:581-591 ( (May) ) 1945. 4. McGuckin, W. F.: Experience With the Auto-Analyzer in the Analysis of Blood for Sugar and Urea , Clin Chem 5:262 ( (June) ) 1959. 5. Astrup, P.; Jorgensen, K.; Andersen, O. S.; and Engel, K.: The Acid-Base Metabolism: A New Approach , Lancet 1:1035-1039 ( (May 14) ) 1960.Crossref 6. Holth, Tore: Separation of Calcium From Magnesium by Oxalate Method: A Critical Study , Analyt Chem 21:1221-1226 ( (Oct) ) 1949.Crossref 7. Lucas, R. C.: On a Form of Late Rickets Associated With Albuminuria, Rickets of Adolescents , Lancet 1:993-994 ( (June 9) ) 1883.Crossref 8. Fletcher, H. M.: Case of Infantilism With Polyuria and Chronic Renal Disease , Proc Roy Soc Med 4:95 ( (March 24) ) 1911. 9. Mitchell, A. G.: Nephrosclerosis (Chronic Interstitial Nephritis) in Childhood , Amer J Dis Child 40:101-145 ( (July) ) 1930.Crossref 10. Graham, S., and Hutchinson, J. H.: Familial Renal Dwarfism , Arch Dis Child 16:253-256, 1941.Crossref 11. Weill-Hallé, B.; Abaza, A.; and Meunier: Sur l'Étiologie du nanisme rénal: Nanisme familial et nanisme par intoxication au cours de la gestation , Bull Soc Pediat Paris 37:266-273 ( (May) ) 1939. 12. Schneider, R. W., and Corcoran, A. C.: Familial Nephrogenic Osteopathy Due to Excessive Tubular Reabsorption of Inorganic Phosphate: A New Syndrome and a Novel Mode of Relief , J Lab Clin Med 36:985-986 ( (Dec) ) 1950. 13. Danis, P. G., and Rossen, J. A.: Renal Rickets , J Pediat 18:103-116 ( (Jan) ) 1941.Crossref 14. Tobias, G. J.; McLaughlin, R. F., Jr.; and Hopper, J., Jr.: Endogenous Creatinine Clearance: A Valuable Clinical Test of Glomerular Filtration and a Prognostic Guide in Chronic Renal Disease , New Engl J Med 266:317-323 ( (Feb 15) ) 1962.Crossref 15. Stanbury, S. W., and Lumb, G. A.: Metabolic Studies of Renal Osteodystrophy: 1. Calcium, Phosphorus and Nitrogen Metabolism in Rickets, Osteomalacia and Hyperparathyroidism Complicating Chronic Uremia and in the Osteomalacia of the Adult Fanconi Syndrome , Medicine 41:1-28 ( (Feb) ) 1962.Crossref 16. Liu, S. H., and Chu, H. I.: Studies of Calcium and Phosphorus Metabolism with Special Reference to Pathogenesis and Effects of Dihydrotachysterol (A.T. 10) and Iron , Medicine 22:103-161 ( (May) ) 1943.Crossref 17. Dent, C. E.; Harper, C. M.; and Philpot, G. R.: The Treatment of Renal-Glomerular Osteodystrophy , Quart J Med 30:1-31 ( (Jan) ) 1961.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: May 1, 1963

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