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Renal Cell Carcinoma and the Widespread Use of NSAIDs : Comment on “Prospective Evaluation of Analgesic Use and Risk of Renal Cell Cancer”

Renal Cell Carcinoma and the Widespread Use of NSAIDs : Comment on “Prospective Evaluation of... An estimated 60 million Americans use nonsteroidal anti-inflammatory drugs (NSAIDs) regularly. The study by Cho et al uses prospective data from 2 different cohorts to estimate the risk of renal cell carcinoma related to NSAID use and reports a pooled multivariate relative risk of 1.51 (95% confidence interval, 1.12-2.04) for nonaspirin NSAID use, with a dose-response relationship based on duration of use. Although the absolute risk differences between users and nonusers of NSAIDS were quite low, we find the results compelling in light of the widespread use of these drugs. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Renal Cell Carcinoma and the Widespread Use of NSAIDs : Comment on “Prospective Evaluation of Analgesic Use and Risk of Renal Cell Cancer”

Archives of Internal Medicine , Volume 171 (16) – Sep 12, 2011

Renal Cell Carcinoma and the Widespread Use of NSAIDs : Comment on “Prospective Evaluation of Analgesic Use and Risk of Renal Cell Cancer”

Abstract

An estimated 60 million Americans use nonsteroidal anti-inflammatory drugs (NSAIDs) regularly. The study by Cho et al uses prospective data from 2 different cohorts to estimate the risk of renal cell carcinoma related to NSAID use and reports a pooled multivariate relative risk of 1.51 (95% confidence interval, 1.12-2.04) for nonaspirin NSAID use, with a dose-response relationship based on duration of use. Although the absolute risk differences between users and nonusers of NSAIDS were quite...
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Publisher
American Medical Association
Copyright
Copyright © 2011 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinternmed.2011.375
Publisher site
See Article on Publisher Site

Abstract

An estimated 60 million Americans use nonsteroidal anti-inflammatory drugs (NSAIDs) regularly. The study by Cho et al uses prospective data from 2 different cohorts to estimate the risk of renal cell carcinoma related to NSAID use and reports a pooled multivariate relative risk of 1.51 (95% confidence interval, 1.12-2.04) for nonaspirin NSAID use, with a dose-response relationship based on duration of use. Although the absolute risk differences between users and nonusers of NSAIDS were quite low, we find the results compelling in light of the widespread use of these drugs.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Sep 12, 2011

Keywords: analgesics,anti-inflammatory agents, non-steroidal,renal cell carcinoma

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