Key PointsQuestionCan a remote, algorithm-driven, navigator-administered medication optimization program enhance implementation of guideline-directed medical therapy in heart failure with reduced ejection fraction? FindingsIn this case-control study of 1028 patients, in 3 months, patients participating in the remote intervention experienced significant increases from baseline in the use and dosages of renin-angiotensin system antagonists and β-blockers but not mineralocorticoid receptor antagonists. Similar changes were not seen in a usual-care comparator group over the same period. MeaningRemote titration of guideline-directed medical therapy by navigators using encoded algorithms may represent an effective strategy for closing the gap between guidelines and clinical practice in patients with heart failure with reduced ejection fraction.
JAMA Cardiology – American Medical Association
Published: Dec 16, 2020
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