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Relationship Between Toxic Erythema and Infant Maturity

Relationship Between Toxic Erythema and Infant Maturity Abstract TOXIC erythema is a benign self-limited dermatitis occurring in newborn infants within the first days of life. The condition was first mentioned by Bartholomaeus Metlinger in 14721 and named erythema toxicum neonatorum by Leiner2 in 1912. It consists of erythematous macular lesions followed by papulovesicular lesions pustules. The etiology of this condition still remains unclear. It is generally agreed that the incidence of toxic erythema is lower in premature infants than in term infants.3,4 This study was undertaken to determine the relation of three parameters of infant maturity to the development of toxic erythem. Materials and Methods A surveillance was made of two term nurseries with an approximate daily population of 25 each and the premature center with an average daily census of 75. All infants less than 12 hours of age when first seen were included in the study and examined daily until their discharge. Term References 1. Lehndorff, H.: Bartholomaeus Metlinger: A Fifteenth Century Pediatrician , Arch Pediat 68:322, 1951. 2. Leiner, C.: Über eigenarriage Erythemtypen und Dermatitiden des frühen Sauglingsalters , Leipsiz: F. Deuticke, 1912. 3. Mayerhofer, E., and Lypolt-Krajnovic, M.: Das Erythema neonatorum toxicum-Leiner ("Erythema populatum" der alten Aerzte) als Teilerscheinung einer allgemeinen Allergie des Naugeborenen , Z Kinderheilk 43:630, 1927.Crossref 4. Duperrat, B., and Bret, A.J.: Erythema Neonatorum Allergicum , Brit J Derm 73:300, 1961.Crossref 5. Lüders, D.: Histologic Observations in Erythema Toxicum Neonatorum , Pediatrics 26:219, 1960. 6. Taylor, W.B., and Bondurant, C.P., Jr.: Erythema Neonatorum Allergicum , Arch Derm 76:591, 1957.Crossref 7. Freeman, R.G.; Spiller, R.; and Knox, J.: Histopathology of Erythema Toxicum Neonatorum , Arch Derm 82:586, 1960.Crossref 8. Harris, J.R., and Schick, B.: Erythema Neonatorum , Amer J Dis Child 92:27, 1956. 9. Keitel, H.G., and Yadav, V.: Etiology of Toxic Erythema , Amer J Dis Child 106:306, 1963.Crossref 10. Saracli, T.; Kenney, J.A., Jr.; and Scott, T.B.: Common Skin Disorders in the Newborn Negro Infant , J Pediat 62:358, 1963.Crossref 11. Schaffer, A.J.: Diseases of the Newborn , Philadelphia: W. B. Saunders Co., 1960, p 770. 12. Levy, H.L., and Cochran, F.: Erythema Toxicum Neonatorum Present at Birth , Amer J Dis Child 103:617, 1962. 13. Marino, J.: Toxic Erythema Present at Birth , Arch Derm 92:402, 1965.Crossref 14. Parmelee, A.H.: Management of the Newborn , Chicago: Year Book Medical Publishers, Inc., 1959, p 88. 15. Hodgman, J.E., et al: The Non-Specific Inflammatory Response in the Mature and Premature Infant, to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1966 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1966.02090110073006
Publisher site
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Abstract

Abstract TOXIC erythema is a benign self-limited dermatitis occurring in newborn infants within the first days of life. The condition was first mentioned by Bartholomaeus Metlinger in 14721 and named erythema toxicum neonatorum by Leiner2 in 1912. It consists of erythematous macular lesions followed by papulovesicular lesions pustules. The etiology of this condition still remains unclear. It is generally agreed that the incidence of toxic erythema is lower in premature infants than in term infants.3,4 This study was undertaken to determine the relation of three parameters of infant maturity to the development of toxic erythem. Materials and Methods A surveillance was made of two term nurseries with an approximate daily population of 25 each and the premature center with an average daily census of 75. All infants less than 12 hours of age when first seen were included in the study and examined daily until their discharge. Term References 1. Lehndorff, H.: Bartholomaeus Metlinger: A Fifteenth Century Pediatrician , Arch Pediat 68:322, 1951. 2. Leiner, C.: Über eigenarriage Erythemtypen und Dermatitiden des frühen Sauglingsalters , Leipsiz: F. Deuticke, 1912. 3. Mayerhofer, E., and Lypolt-Krajnovic, M.: Das Erythema neonatorum toxicum-Leiner ("Erythema populatum" der alten Aerzte) als Teilerscheinung einer allgemeinen Allergie des Naugeborenen , Z Kinderheilk 43:630, 1927.Crossref 4. Duperrat, B., and Bret, A.J.: Erythema Neonatorum Allergicum , Brit J Derm 73:300, 1961.Crossref 5. Lüders, D.: Histologic Observations in Erythema Toxicum Neonatorum , Pediatrics 26:219, 1960. 6. Taylor, W.B., and Bondurant, C.P., Jr.: Erythema Neonatorum Allergicum , Arch Derm 76:591, 1957.Crossref 7. Freeman, R.G.; Spiller, R.; and Knox, J.: Histopathology of Erythema Toxicum Neonatorum , Arch Derm 82:586, 1960.Crossref 8. Harris, J.R., and Schick, B.: Erythema Neonatorum , Amer J Dis Child 92:27, 1956. 9. Keitel, H.G., and Yadav, V.: Etiology of Toxic Erythema , Amer J Dis Child 106:306, 1963.Crossref 10. Saracli, T.; Kenney, J.A., Jr.; and Scott, T.B.: Common Skin Disorders in the Newborn Negro Infant , J Pediat 62:358, 1963.Crossref 11. Schaffer, A.J.: Diseases of the Newborn , Philadelphia: W. B. Saunders Co., 1960, p 770. 12. Levy, H.L., and Cochran, F.: Erythema Toxicum Neonatorum Present at Birth , Amer J Dis Child 103:617, 1962. 13. Marino, J.: Toxic Erythema Present at Birth , Arch Derm 92:402, 1965.Crossref 14. Parmelee, A.H.: Management of the Newborn , Chicago: Year Book Medical Publishers, Inc., 1959, p 88. 15. Hodgman, J.E., et al: The Non-Specific Inflammatory Response in the Mature and Premature Infant, to be published.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Aug 1, 1966

References