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RELATION OF RELAPSES IN TYPHOID TO DURATION OF CHLORAMPHENICOL THERAPY

RELATION OF RELAPSES IN TYPHOID TO DURATION OF CHLORAMPHENICOL THERAPY During the past year much information has accumulated on the use of chloramphenicol (chloromycetin®) in the treatment of typhoid. This confirms the original report of Woodward and others,1 covering the observations on 10 patients, which clearly indicated that the new antibiotic was of great value in this disease. Continued experience reveals that fever disappears by lysis during the first three or four days of treatment. Our early observations,1 as well as those of McDermott and his associates,2 brought out that relapses of typhoid were common in treated patients. In order to eliminate such occurrences, we have prolonged the course of treatment in persons infected with Salmonella typhosa. Analysis of the results obtained in 44 patients with typhoid who received chloramphenicol therapeutically under our observation has indicated a striking relation between the duration of chemotherapy and the incidence of relapses. Although our observations are being reported in detail http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

RELATION OF RELAPSES IN TYPHOID TO DURATION OF CHLORAMPHENICOL THERAPY

SMADEL, JOSEPH E.; WOODWARD, THEODORE E.; BAILEY, CHARLES A.
JAMA , Volume 141 (2) – Sep 10, 1949
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RELATION OF RELAPSES IN TYPHOID TO DURATION OF CHLORAMPHENICOL THERAPY

Abstract


During the past year much information has accumulated on the use of chloramphenicol (chloromycetin®) in the treatment of typhoid. This confirms the original report of Woodward and others,1 covering the observations on 10 patients, which clearly indicated that the new antibiotic was of great value in this disease. Continued experience reveals that fever disappears by lysis during the first three or four days of treatment.
Our early observations,1 as well as those of McDermott and his...
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References (1)

Publisher
American Medical Association
Copyright
Copyright © 1949 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1949.62910020002006b
Publisher site
See Article on Publisher Site

Abstract

During the past year much information has accumulated on the use of chloramphenicol (chloromycetin®) in the treatment of typhoid. This confirms the original report of Woodward and others,1 covering the observations on 10 patients, which clearly indicated that the new antibiotic was of great value in this disease. Continued experience reveals that fever disappears by lysis during the first three or four days of treatment. Our early observations,1 as well as those of McDermott and his associates,2 brought out that relapses of typhoid were common in treated patients. In order to eliminate such occurrences, we have prolonged the course of treatment in persons infected with Salmonella typhosa. Analysis of the results obtained in 44 patients with typhoid who received chloramphenicol therapeutically under our observation has indicated a striking relation between the duration of chemotherapy and the incidence of relapses. Although our observations are being reported in detail

Journal

JAMA – American Medical Association

Published: Sep 10, 1949

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