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Relapses After CAR-T Therapy

Relapses After CAR-T Therapy News & Analysis Biotech Innovations Recovery of Voluntary Movement leak back into the organ’s left atrium and Relapses After CAR-T Therapy After Paralysis the lungs, further worsening the condition. A case study recently published in Nature Medicine describes a rare mechanism of fatal In 2 recent studies, patients with lower- Some patients remain symptomatic despite limb paralysis achieved overground walk- receiving maximal heart failure therapies. relapse following chimeric antigen recep- tor T cell (CAR-T) therapy. ing after spinal cord epidural electrical stimulation combined with intensive loco- Researchers at the University of Penn- motor training. sylvania (Penn)—where CAR-T therapies against cancer were first developed— Researchers at the University of Louis- ville and the Frazier Rehab Institute tested reported that a 20-year-old male pa- tient with B–cell acute lymphoblastic leu- the therapy on 4 patients with motor com- plete spinal cord injuries, in which some kemia began to relapse 9 months after receiving the treatment as part of a phase sensation but no voluntary movement exists below the injury. After months of 1 trial of the then-investigational agent CTL019 (tisagenlecleucel, now marketed daily sessions, all 4 patients achieved inde- pendent standing and trunk stability and 2 by Novartis as Kymriah). A http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Relapses After CAR-T Therapy

Abbasi, Jennifer
JAMA , Volume 320 (18) – Nov 13, 2018
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Relapses After CAR-T Therapy

Abstract

News & Analysis Biotech Innovations Recovery of Voluntary Movement leak back into the organ’s left atrium and Relapses After CAR-T Therapy After Paralysis the lungs, further worsening the condition. A case study recently published in Nature Medicine describes a rare mechanism of fatal In 2 recent studies, patients with lower- Some patients remain symptomatic despite limb paralysis achieved overground walk- receiving maximal heart failure therapies. relapse following chimeric antigen...
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Publisher
American Medical Association
Copyright
Copyright 2018 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2018.17585
pmid
30422179
Publisher site
See Article on Publisher Site

Abstract

News & Analysis Biotech Innovations Recovery of Voluntary Movement leak back into the organ’s left atrium and Relapses After CAR-T Therapy After Paralysis the lungs, further worsening the condition. A case study recently published in Nature Medicine describes a rare mechanism of fatal In 2 recent studies, patients with lower- Some patients remain symptomatic despite limb paralysis achieved overground walk- receiving maximal heart failure therapies. relapse following chimeric antigen recep- tor T cell (CAR-T) therapy. ing after spinal cord epidural electrical stimulation combined with intensive loco- Researchers at the University of Penn- motor training. sylvania (Penn)—where CAR-T therapies against cancer were first developed— Researchers at the University of Louis- ville and the Frazier Rehab Institute tested reported that a 20-year-old male pa- tient with B–cell acute lymphoblastic leu- the therapy on 4 patients with motor com- plete spinal cord injuries, in which some kemia began to relapse 9 months after receiving the treatment as part of a phase sensation but no voluntary movement exists below the injury. After months of 1 trial of the then-investigational agent CTL019 (tisagenlecleucel, now marketed daily sessions, all 4 patients achieved inde- pendent standing and trunk stability and 2 by Novartis as Kymriah). A

Journal

JAMA – American Medical Association

Published: Nov 13, 2018

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