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Regional Lung-Function Abnormalities in Narcotic Addicts

Regional Lung-Function Abnormalities in Narcotic Addicts Measurement of regional lung function with radioactive xenon (133Xe) gas and normal albumin microspheres (human) labelled with technetium 99m in 18 narcotic addicts without respiratory symptoms revealed that 73% (13/18) of the subjects had abnormalities of regional perfusion. These defects were mostly diffuse and nonsegmental. Twenty-seven percent (5/18) had abnormal regional ventilation characterized by delayed clearance of inhaled133Xe. All five had used heroin parenterally for long periods (mean, 7.5 years) in large amounts (eight bags a day), and abstinence prior to the study was brief. Six subjects who had abstained from parenteral use of narcotics for more than two years had abnormalities of regional perfusion only, their ventilation being normal. Abnormal regional perfusion was probably due to foreign body granuloma and embolism in pulmonary vessels. The cause of abnormal regional ventilation is not clear. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Regional Lung-Function Abnormalities in Narcotic Addicts

Soin, Jagmeet S.; McKusick, Kenneth A.; Wagner, Henry N.
JAMA , Volume 224 (13) – Jun 25, 1973
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References (10)

Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1973.03220270013004
Publisher site
See Article on Publisher Site

Abstract

Measurement of regional lung function with radioactive xenon (133Xe) gas and normal albumin microspheres (human) labelled with technetium 99m in 18 narcotic addicts without respiratory symptoms revealed that 73% (13/18) of the subjects had abnormalities of regional perfusion. These defects were mostly diffuse and nonsegmental. Twenty-seven percent (5/18) had abnormal regional ventilation characterized by delayed clearance of inhaled133Xe. All five had used heroin parenterally for long periods (mean, 7.5 years) in large amounts (eight bags a day), and abstinence prior to the study was brief. Six subjects who had abstained from parenteral use of narcotics for more than two years had abnormalities of regional perfusion only, their ventilation being normal. Abnormal regional perfusion was probably due to foreign body granuloma and embolism in pulmonary vessels. The cause of abnormal regional ventilation is not clear.

Journal

JAMA – American Medical Association

Published: Jun 25, 1973

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