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Refractive Keratoplasty: Keratophakia in a Nonhuman Primate

Refractive Keratoplasty: Keratophakia in a Nonhuman Primate Abstract • We performed 11 keratophakia procedures in a baboon (Papio cynocephalus) model using the same instruments and techniques that are presently clinically employed. We requested 10 diopters of correction in nine cases and 14 D in two cases. We were able to achieve a mean (±SD) keratometric steepening correction of 5.8 ± 1.5 D using fresh and 9.3 ± 5.0 D using prefrozen donor corneas. The overall change was 8.0 ± 4.3 D. Morphologic results and corneal clarity were consistent with the excellent clinical results. The keratophakia lenticles were sparsely repopulated with keratocytes up to six months following surgery, but at 12 months, partial keratocyte repopulation of one lenticle did occur. We recommend that the baboon model be used for evaluation of all lamellar refractive surgical procedures. References 1. Barraquer JI: Queratomileusis y queratofaquia . Bogotá, Columbia, Lithografia ARCO, 1980. 2. Beale JP Jr: Microsurgical correction of optical errors: Refractive keratoplasty and intraocular lenses . Adv Ophthalmol 1978;37:159-164. 3. Troutman RC, Swinger CA, Kelly RJ: Keratophakia: A preliminary evaluation . Ophthalmology 1979;86:523-530.Crossref 4. Binder PS, Akers PH, Deg JK, et al: Refractive keratoplasty: Microkeratome evaluation . Arch Ophthalmol 1982;100:802-806.Crossref 5. Binder PS, Deg JK, Akers PH, et al: Refractive keratoplasty: Cryopreservation evaluation . Invest Ophthalmol Vis Sci 1981( (suppl) );20:67. 6. Binder PS, Zavala EY, Deg JK, et al: Refractive keratoplasty tissue dyes and cryoprotective solutions . Arch Ophthalmol 1983;101:1591-1596.Crossref 7. Tucker DN, Barraquer JI: Refractive keratoplasty: Clinical results in 67 cases . Ann Ophthalmol 1973;5:335-352. 8. Troutman RC, Swinger CA, Goldstein M: Keratophakia update . Ophthalmology 1981;88:36-38.Crossref 9. Swinger CA, Barraquer JI: Keratophakia and keratomileusis: Clinical results . Ophthalmology 1981;88:709-715.Crossref 10. Friedlander MH, Werblin TP, Kaufman HE, et al: Clinical results of keratophakia and keratomileusis . Ophthalmology 1981;88:716-720.Crossref 11. Swinger CA: The correction of aphakia: A comparison . Int Ophthalmol Clin 1983;23( (3) ):59-74.Crossref 12. Jakobiec FA, Koch P, Iwamoto T, et al: Keratophakia and keratomileusis: Comparison of pathologic features in penetrating keratoplasty specimens . Ophthalmology 1981;88:1251-1259.Crossref 13. Koch PS, Jakobiec FA, Iwamoto, et al: The ultrastructure of human lenticule in keratophakia . Arch Ophthalmol 1981;99:1634-1639.Crossref 14. Binder PS, Beale JP Jr, Zavala EY: The histopathology of a case of keratophakia . Arch Ophthalmol 1982;100:101-105.Crossref 15. Breaux BE, Villasenor RA: Myopic keratomileusis: Histopathology and clinical correlation . Cornea 1982;1:65-69.Crossref 16. Binder PS, Villasenor RA, Shaw EL, et al: The histopathology of human refractive keratoplasty , in Henkind P, Shimizu K, Blodi FC, et al (eds): Acta 24th International Congress of Ophthalmology . Philadelphia, JB Lippincott Co, 1983, vol 1, pp 312-318. 17. Villasenor RA, Jester JV, Salz J, et al: Preliminary study of keratomileusis in primates (Macaca speciosa) . Ophthalmology 1981;88:724-728.Crossref 18. Binder PS, Deg JK, Zavala EY, et al: Hydrogel keratophakia in non-human primates . Curr Eye Res 1981/1982;1:535-542.Crossref 19. Friedlander MH, Rich LF, Werblin TP, et al: Keratophakia using preserved lenticules . Ophthalmology 1980;87:687-692.Crossref 20. Zavala EY, Binder PS: The pathologic findings of epithelial ingrowth . Arch Ophthalmol 1980;98:2007-2014.Crossref 21. Schanzlin DJ, Jester JV, Kay E: Cryolathe corneal injury . Cornea 1983;2:57-68.Crossref 22. Binder PS, Baumgartner SD, Zavala EY, et al: Refractive keratoplasty: Myopic keratomileusis in baboons. Curr Eye Res, in press. 23. Binder PS, May CH, Grant SC: An evaluation of orthokeratology . Ophthalmology 1980; 87:729-744.Crossref 24. Rowsey JJ, Balyeat HD: Preliminary results and complications of radial keratotomy . Am J Ophthalmol 1982;93:437-455. 25. Safir A, McDonald MB, Klyce SD, et al: The cornea press: Restoring donor corneas to normal dimensions and hydration before cryolathing . Ophthalmic Surg 1983;14:327-331. 26. Werblin TP, Kaufman HE, Friedlander MH, et al: Epikeratophakia: The surgical correction of aphakia: Update 1981 . Ophthalmology 1982;89:916-920.Crossref 27. Binder PS, Zavala EY, Deg JK, et al: Hydrophilic lenses for refractive keratoplasty: The use of factory lathed materials . Contact Lens Assoc Ophthalmologists 1984;10:105-111. 28. Binder PS, Zavala EY, Deg JK: Hydrogel refractive keratoplasty: Lens removal and exchanges . Cornea 1983;2:119-125. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Refractive Keratoplasty: Keratophakia in a Nonhuman Primate

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Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1984.01040031355026
Publisher site
See Article on Publisher Site

Abstract

Abstract • We performed 11 keratophakia procedures in a baboon (Papio cynocephalus) model using the same instruments and techniques that are presently clinically employed. We requested 10 diopters of correction in nine cases and 14 D in two cases. We were able to achieve a mean (±SD) keratometric steepening correction of 5.8 ± 1.5 D using fresh and 9.3 ± 5.0 D using prefrozen donor corneas. The overall change was 8.0 ± 4.3 D. Morphologic results and corneal clarity were consistent with the excellent clinical results. The keratophakia lenticles were sparsely repopulated with keratocytes up to six months following surgery, but at 12 months, partial keratocyte repopulation of one lenticle did occur. We recommend that the baboon model be used for evaluation of all lamellar refractive surgical procedures. References 1. Barraquer JI: Queratomileusis y queratofaquia . Bogotá, Columbia, Lithografia ARCO, 1980. 2. Beale JP Jr: Microsurgical correction of optical errors: Refractive keratoplasty and intraocular lenses . Adv Ophthalmol 1978;37:159-164. 3. Troutman RC, Swinger CA, Kelly RJ: Keratophakia: A preliminary evaluation . Ophthalmology 1979;86:523-530.Crossref 4. Binder PS, Akers PH, Deg JK, et al: Refractive keratoplasty: Microkeratome evaluation . Arch Ophthalmol 1982;100:802-806.Crossref 5. Binder PS, Deg JK, Akers PH, et al: Refractive keratoplasty: Cryopreservation evaluation . Invest Ophthalmol Vis Sci 1981( (suppl) );20:67. 6. Binder PS, Zavala EY, Deg JK, et al: Refractive keratoplasty tissue dyes and cryoprotective solutions . Arch Ophthalmol 1983;101:1591-1596.Crossref 7. Tucker DN, Barraquer JI: Refractive keratoplasty: Clinical results in 67 cases . Ann Ophthalmol 1973;5:335-352. 8. Troutman RC, Swinger CA, Goldstein M: Keratophakia update . Ophthalmology 1981;88:36-38.Crossref 9. Swinger CA, Barraquer JI: Keratophakia and keratomileusis: Clinical results . Ophthalmology 1981;88:709-715.Crossref 10. Friedlander MH, Werblin TP, Kaufman HE, et al: Clinical results of keratophakia and keratomileusis . Ophthalmology 1981;88:716-720.Crossref 11. Swinger CA: The correction of aphakia: A comparison . Int Ophthalmol Clin 1983;23( (3) ):59-74.Crossref 12. Jakobiec FA, Koch P, Iwamoto T, et al: Keratophakia and keratomileusis: Comparison of pathologic features in penetrating keratoplasty specimens . Ophthalmology 1981;88:1251-1259.Crossref 13. Koch PS, Jakobiec FA, Iwamoto, et al: The ultrastructure of human lenticule in keratophakia . Arch Ophthalmol 1981;99:1634-1639.Crossref 14. Binder PS, Beale JP Jr, Zavala EY: The histopathology of a case of keratophakia . Arch Ophthalmol 1982;100:101-105.Crossref 15. Breaux BE, Villasenor RA: Myopic keratomileusis: Histopathology and clinical correlation . Cornea 1982;1:65-69.Crossref 16. Binder PS, Villasenor RA, Shaw EL, et al: The histopathology of human refractive keratoplasty , in Henkind P, Shimizu K, Blodi FC, et al (eds): Acta 24th International Congress of Ophthalmology . Philadelphia, JB Lippincott Co, 1983, vol 1, pp 312-318. 17. Villasenor RA, Jester JV, Salz J, et al: Preliminary study of keratomileusis in primates (Macaca speciosa) . Ophthalmology 1981;88:724-728.Crossref 18. Binder PS, Deg JK, Zavala EY, et al: Hydrogel keratophakia in non-human primates . Curr Eye Res 1981/1982;1:535-542.Crossref 19. Friedlander MH, Rich LF, Werblin TP, et al: Keratophakia using preserved lenticules . Ophthalmology 1980;87:687-692.Crossref 20. Zavala EY, Binder PS: The pathologic findings of epithelial ingrowth . Arch Ophthalmol 1980;98:2007-2014.Crossref 21. Schanzlin DJ, Jester JV, Kay E: Cryolathe corneal injury . Cornea 1983;2:57-68.Crossref 22. Binder PS, Baumgartner SD, Zavala EY, et al: Refractive keratoplasty: Myopic keratomileusis in baboons. Curr Eye Res, in press. 23. Binder PS, May CH, Grant SC: An evaluation of orthokeratology . Ophthalmology 1980; 87:729-744.Crossref 24. Rowsey JJ, Balyeat HD: Preliminary results and complications of radial keratotomy . Am J Ophthalmol 1982;93:437-455. 25. Safir A, McDonald MB, Klyce SD, et al: The cornea press: Restoring donor corneas to normal dimensions and hydration before cryolathing . Ophthalmic Surg 1983;14:327-331. 26. Werblin TP, Kaufman HE, Friedlander MH, et al: Epikeratophakia: The surgical correction of aphakia: Update 1981 . Ophthalmology 1982;89:916-920.Crossref 27. Binder PS, Zavala EY, Deg JK, et al: Hydrophilic lenses for refractive keratoplasty: The use of factory lathed materials . Contact Lens Assoc Ophthalmologists 1984;10:105-111. 28. Binder PS, Zavala EY, Deg JK: Hydrogel refractive keratoplasty: Lens removal and exchanges . Cornea 1983;2:119-125.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Nov 1, 1984

References