Abstract Several therapeutic regimens combining topical agents with UV light have been developed and widely used in the treatment of psoriasis. In this study, we compared the clinical efficacy and safety of the combined therapy of oral psoralen plus UV-A (PUVA) with calcipotriol vs PUVA therapy alone. Materials and Methods. Twenty-eight outpatients (11 women and 17 men), with mean age of 45 years (age range, 20-69 years), with moderate, chronic, stable plaque psoriasis (Psoriasis Area and Severity Index range, 8-15) were enrolled in this study. Patients had not used systemic antipsoriatic drugs or UV radiation therapy for at least 2 months and topical treatment for at least 2 weeks prior to the study.Women were included only if they were not pregnant or breast-feeding. We excluded patients receiving treatment with vitamin D or calcium, phosphate, or other drugs that might influence calcium or phosphate metabolism (eg, steroids or biphosphonate); patients needing References 1. Bruynzeel I, Bergman W, Hartevelt HM, et al. 'High single dose' European PUVA regimen also causes an excess of non-melanoma skin cancer . Br J Dermatol. 1991;124:49-55.Crossref 2. Speight EL, Farr PM. Calcipotriol improves the response of psoriasis to PUVA . Br J Dermatol. 1994;130:79-82.Crossref 3. Frappaz A, Thivolet J. Calcipotriol in combination with PUVA: a randomized, double-blind, placebo study in severe psoriasis . Eur J Dermatol. 1993; 3:351-354. 4. Kokelj F, Lavaroni G, Perkan V, Plozzer C. Hyperpigmentation due to calcipotriol (MC 903) plus heliotherapy in psoriatic patients: three case reports . Acta Derm Venereol. 1995;75:307-309.
Archives of Dermatology – American Medical Association
Published: May 1, 1997