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Reduction of UV-A Radiation Induced by Calcipotriol in the Treatment of Vulgar Psoriasis With Oral Psoralen Plus UV-A

Reduction of UV-A Radiation Induced by Calcipotriol in the Treatment of Vulgar Psoriasis With... Abstract Several therapeutic regimens combining topical agents with UV light have been developed and widely used in the treatment of psoriasis. In this study, we compared the clinical efficacy and safety of the combined therapy of oral psoralen plus UV-A (PUVA) with calcipotriol vs PUVA therapy alone. Materials and Methods. Twenty-eight outpatients (11 women and 17 men), with mean age of 45 years (age range, 20-69 years), with moderate, chronic, stable plaque psoriasis (Psoriasis Area and Severity Index range, 8-15) were enrolled in this study. Patients had not used systemic antipsoriatic drugs or UV radiation therapy for at least 2 months and topical treatment for at least 2 weeks prior to the study.Women were included only if they were not pregnant or breast-feeding. We excluded patients receiving treatment with vitamin D or calcium, phosphate, or other drugs that might influence calcium or phosphate metabolism (eg, steroids or biphosphonate); patients needing References 1. Bruynzeel I, Bergman W, Hartevelt HM, et al. 'High single dose' European PUVA regimen also causes an excess of non-melanoma skin cancer . Br J Dermatol. 1991;124:49-55.Crossref 2. Speight EL, Farr PM. Calcipotriol improves the response of psoriasis to PUVA . Br J Dermatol. 1994;130:79-82.Crossref 3. Frappaz A, Thivolet J. Calcipotriol in combination with PUVA: a randomized, double-blind, placebo study in severe psoriasis . Eur J Dermatol. 1993; 3:351-354. 4. Kokelj F, Lavaroni G, Perkan V, Plozzer C. Hyperpigmentation due to calcipotriol (MC 903) plus heliotherapy in psoriatic patients: three case reports . Acta Derm Venereol. 1995;75:307-309. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Reduction of UV-A Radiation Induced by Calcipotriol in the Treatment of Vulgar Psoriasis With Oral Psoralen Plus UV-A

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Publisher
American Medical Association
Copyright
Copyright © 1997 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1997.03890410132029
Publisher site
See Article on Publisher Site

Abstract

Abstract Several therapeutic regimens combining topical agents with UV light have been developed and widely used in the treatment of psoriasis. In this study, we compared the clinical efficacy and safety of the combined therapy of oral psoralen plus UV-A (PUVA) with calcipotriol vs PUVA therapy alone. Materials and Methods. Twenty-eight outpatients (11 women and 17 men), with mean age of 45 years (age range, 20-69 years), with moderate, chronic, stable plaque psoriasis (Psoriasis Area and Severity Index range, 8-15) were enrolled in this study. Patients had not used systemic antipsoriatic drugs or UV radiation therapy for at least 2 months and topical treatment for at least 2 weeks prior to the study.Women were included only if they were not pregnant or breast-feeding. We excluded patients receiving treatment with vitamin D or calcium, phosphate, or other drugs that might influence calcium or phosphate metabolism (eg, steroids or biphosphonate); patients needing References 1. Bruynzeel I, Bergman W, Hartevelt HM, et al. 'High single dose' European PUVA regimen also causes an excess of non-melanoma skin cancer . Br J Dermatol. 1991;124:49-55.Crossref 2. Speight EL, Farr PM. Calcipotriol improves the response of psoriasis to PUVA . Br J Dermatol. 1994;130:79-82.Crossref 3. Frappaz A, Thivolet J. Calcipotriol in combination with PUVA: a randomized, double-blind, placebo study in severe psoriasis . Eur J Dermatol. 1993; 3:351-354. 4. Kokelj F, Lavaroni G, Perkan V, Plozzer C. Hyperpigmentation due to calcipotriol (MC 903) plus heliotherapy in psoriatic patients: three case reports . Acta Derm Venereol. 1995;75:307-309.

Journal

Archives of DermatologyAmerican Medical Association

Published: May 1, 1997

References